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Nav1 neuron navigator 1 [ Mus musculus (house mouse) ]

Gene ID: 215690, updated on 11-Apr-2024

Summary

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Official Symbol
Nav1provided by MGI
Official Full Name
neuron navigator 1provided by MGI
Primary source
MGI:MGI:2183683
See related
Ensembl:ENSMUSG00000009418 AllianceGenome:MGI:2183683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm38399; Pomfil3; Unc53h1; mKIAA1151; steerin-1; 9530089B19; 9930003A20Rik; C230080M11Rik
Summary
Acts upstream of or within microtubule bundle formation and neuron migration. Located in axon initial segment and microtubule cytoskeleton. Is expressed in several structures, including central nervous system; embryo mesenchyme; molar; peripheral nervous system ganglion; and sensory organ. Orthologous to human NAV1 (neuron navigator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 16.8), whole brain E14.5 (RPKM 14.4) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Nav1 in Genome Data Viewer
Location:
1; 1 E4
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135362318..135616082, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135434580..135688350, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene shisa family member 4 Neighboring gene STARR-seq mESC enhancer starr_02365 Neighboring gene importin 9 Neighboring gene STARR-positive B cell enhancer ABC_E10038 Neighboring gene microRNA 1231 Neighboring gene STARR-seq mESC enhancer starr_02370 Neighboring gene STARR-seq mESC enhancer starr_02371 Neighboring gene predicted gene, 32940 Neighboring gene predicted gene 4793 Neighboring gene STARR-seq mESC enhancer starr_02376 Neighboring gene STARR-seq mESC enhancer starr_02385 Neighboring gene cysteine and glycine-rich protein 1 Neighboring gene predicted gene, 53478 Neighboring gene STARR-positive B cell enhancer ABC_E2561 Neighboring gene STARR-seq mESC enhancer starr_02387 Neighboring gene STARR-seq mESC enhancer starr_02388 Neighboring gene STARR-seq mESC enhancer starr_02389 Neighboring gene pleckstrin homology like domain, family A, member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The +TIP Navigator-1 is an actin-microtubule crosslinker that regulates axonal growth cone motility. Sánchez-Huertas C, et al. J Cell Biol, 2020 Sep 7. PMID 32497170, Free PMC Article
  2. Growth cone macropinocytosis of neurotrophin receptor and neuritogenesis are regulated by neuron navigator 1. Powers RM, et al. Mol Biol Cell, 2022 Jun 1. PMID 35352947, Free PMC Article
  3. Mouse neuron navigator 1, a novel microtubule-associated protein involved in neuronal migration. Martínez-López MJ, et al. Mol Cell Neurosci, 2005 Apr. PMID 15797708
  4. Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans. Maes T, et al. Genomics, 2002 Jul. PMID 12079279
  5. Poly (ADP-Ribose) Polymerase 1 Regulates Cajal-Retzius Cell Development and Neural Precursor Cell Adhesion. Nelson MM, et al. Front Cell Dev Biol, 2021. PMID 34708032, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule bundle formation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule bundle formation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axon initial segment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon initial segment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
neuron navigator 1
Names
Steerin1
pore membrane and/or filament-interacting-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427516.1 → NP_001414445.1  neuron navigator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC016814, AC120396, AC120405, AC162441

  2. NM_173437.2 → NP_775613.2  neuron navigator 1 isoform 2

    See identical proteins and their annotated locations for NP_775613.2

    Status: VALIDATED

    Source sequence(s)
    AC016814, AK122458, AK140435, AK153742, CB523329, CN455316
    Consensus CDS
    CCDS35720.1
    UniProtKB/Swiss-Prot
    Q3U5B6, Q68EE8, Q6PB78, Q80TI7, Q8BKG2, Q8BUT5, Q8CH77
    UniProtKB/TrEMBL
    A0A589P973
    Related
    ENSMUSP00000067241.7, ENSMUST00000067414.13
    Conserved Domains (2) summary
    cd00009
    Location:1552 → 1659
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    smart00382
    Location:1548 → 1659
    AAA; ATPases associated with a variety of cellular activities

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    135362318..135616082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252963.1 → XP_030108823.1  neuron navigator 1 isoform X12

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (2) summary
    smart00382
    Location:1561 → 1672
    AAA; ATPases associated with a variety of cellular activities
    TIGR02168
    Location:1090 → 1174
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_030252962.2 → XP_030108822.1  neuron navigator 1 isoform X11

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:1564 → 1675
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:10 → 260
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:1093 → 1177
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_006529378.4 → XP_006529441.1  neuron navigator 1 isoform X10

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:1581 → 1692
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27 → 277
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:1110 → 1194
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. XM_036163515.1 → XP_036019408.1  neuron navigator 1 isoform X9

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:1780 → 1891
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27 → 277
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:1315 → 1396
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. XM_006529377.4 → XP_006529440.1  neuron navigator 1 isoform X8

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:1783 → 1894
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27 → 277
    PHA03247; large tegument protein UL36; Provisional
    TIGR04211
    Location:1315 → 1394
    SH3_and_anchor; SH3 domain protein

  6. XM_006529376.4 → XP_006529439.1  neuron navigator 1 isoform X7

    UniProtKB/TrEMBL
    A0A589P973
    Related
    ENSMUSP00000140322.3, ENSMUST00000190298.8
    Conserved Domains (3) summary
    smart00382
    Location:1788 → 1899
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27 → 277
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:1320 → 1404
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  7. XM_006529375.4 → XP_006529438.1  neuron navigator 1 isoform X6

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:1791 → 1902
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27 → 277
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:1320 → 1404
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  8. XM_006529373.4 → XP_006529436.1  neuron navigator 1 isoform X4

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:1837 → 1948
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27 → 277
    PHA03247; large tegument protein UL36; Provisional
    TIGR04211
    Location:1372 → 1451
    SH3_and_anchor; SH3 domain protein

  9. XM_006529372.4 → XP_006529435.1  neuron navigator 1 isoform X3

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:1840 → 1951
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27 → 277
    PHA03247; large tegument protein UL36; Provisional
    TIGR04211
    Location:1372 → 1451
    SH3_and_anchor; SH3 domain protein

  10. XM_006529371.4 → XP_006529434.1  neuron navigator 1 isoform X2

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:1845 → 1956
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27 → 277
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:1377 → 1461
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  11. XM_006529369.4 → XP_006529432.1  neuron navigator 1 isoform X1

    See identical proteins and their annotated locations for XP_006529432.1

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:1848 → 1959
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27 → 277
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:1377 → 1461
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  12. XM_006529370.4 → XP_006529433.1  neuron navigator 1 isoform X1

    See identical proteins and their annotated locations for XP_006529433.1

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:1848 → 1959
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27 → 277
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:1377 → 1461
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  13. XM_017319805.2 → XP_017175294.1  neuron navigator 1 isoform X1

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:1848 → 1959
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27 → 277
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:1377 → 1461
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  14. XM_017319809.1 → XP_017175298.1  neuron navigator 1 isoform X5

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:1831 → 1942
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:10 → 260
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:1360 → 1444
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  15. XM_006529379.4 → XP_006529442.1  neuron navigator 1 isoform X12

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (2) summary
    smart00382
    Location:1561 → 1672
    AAA; ATPases associated with a variety of cellular activities
    TIGR02168
    Location:1090 → 1174
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  16. XM_006529380.5 → XP_006529443.1  neuron navigator 1 isoform X13

    Conserved Domains (2) summary
    smart00382
    Location:1154 → 1265
    AAA; ATPases associated with a variety of cellular activities
    TIGR02168
    Location:683 → 767
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_004941778.1 RNA Sequence

  2. XR_003954495.1 RNA Sequence

  3. XR_878320.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CH77.2 GenPept UniProtKB/Swiss-Prot:Q8CH77

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