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Cdh12 cadherin 12 [ Mus musculus (house mouse) ]

Gene ID: 215654, updated on 11-Apr-2024

Summary

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Official Symbol
Cdh12provided by MGI
Official Full Name
cadherin 12provided by MGI
Primary source
MGI:MGI:109503
See related
Ensembl:ENSMUSG00000040452 AllianceGenome:MGI:109503
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cdhb
Summary
This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is expressed in both the excitatory and inhibitory neurons in various areas of the adult central nervous system including the cerebellum, neocortex, hippocampus and in different subcortical nuclei. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 15. [provided by RefSeq, Nov 2015]
Expression
Biased expression in cortex adult (RPKM 1.4), frontal lobe adult (RPKM 0.9) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 A2; 15 8.25 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (20448967..21598668)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (20448878..21598421)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25976 Neighboring gene STARR-seq mESC enhancer starr_38117 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_38118 Neighboring gene STARR-seq mESC enhancer starr_38119 Neighboring gene acyl-CoA thioesterase 10 Neighboring gene predicted gene, 25711 Neighboring gene STARR-seq mESC enhancer starr_38121 Neighboring gene STARR-seq mESC enhancer starr_38122 Neighboring gene STARR-seq mESC enhancer starr_38123 Neighboring gene STARR-seq mESC enhancer starr_38124 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene predicted gene, 25101 Neighboring gene STARR-seq mESC enhancer starr_38125 Neighboring gene STARR-seq mESC enhancer starr_38126 Neighboring gene STARR-seq mESC enhancer starr_38127 Neighboring gene STARR-seq mESC enhancer starr_38128 Neighboring gene STARR-seq mESC enhancer starr_38129 Neighboring gene STARR-seq mESC enhancer starr_38132 Neighboring gene STARR-seq mESC enhancer starr_38133 Neighboring gene STARR-seq mESC enhancer starr_38134 Neighboring gene STARR-seq mESC enhancer starr_38135 Neighboring gene predicted gene, 41278 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like 2, pseudogene 2 Neighboring gene cadherin 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular characterization of Br-cadherin, a developmentally regulated, brain-specific cadherin. Selig S, et al. Proc Natl Acad Sci U S A, 1997 Mar 18. PMID 9122206, Free PMC Article
  2. Expression of two type II cadherins, Cdh12 and Cdh22 in the developing and adult mouse brain. Mayer M, et al. Gene Expr Patterns, 2010 Oct-Dec. PMID 20723620
  3. Comparative analysis of type II classic cadherin mRNA distribution patterns in the developing and adult mouse somatosensory cortex and hippocampus suggests significant functional redundancy. Lefkovics K, et al. J Comp Neurol, 2012 May 1. PMID 22102170
  4. Differential Spatiotemporal Expression of Type I and Type II Cadherins Associated With the Segmentation of the Central Nervous System and Formation of Brain Nuclei in the Developing Mouse. Polanco J, et al. Front Mol Neurosci, 2021. PMID 33833667, Free PMC Article
  5. Type II cadherins guide assembly of a direction-selective retinal circuit. Duan X, et al. Cell, 2014 Aug 14. PMID 25126785

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC92959

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cadherin-12
Names
Br-cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008420.3 → NP_001008420.1  cadherin-12 preproprotein

    See identical proteins and their annotated locations for NP_001008420.1

    Status: VALIDATED

    Source sequence(s)
    AC116657, AC118645, AC119811, AC122340
    Consensus CDS
    CCDS27396.1
    UniProtKB/Swiss-Prot
    Q5RJH3
    Related
    ENSMUSP00000074632.7, ENSMUST00000075132.8
    Conserved Domains (3) summary
    cd11304
    Location:164 → 265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80 → 158
    CA; Cadherin repeats
    pfam01049
    Location:638 → 785
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    20448967..21598668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245344.4 → XP_011243646.1  cadherin-12 isoform X1

    See identical proteins and their annotated locations for XP_011243646.1

    UniProtKB/Swiss-Prot
    Q5RJH3
    Conserved Domains (3) summary
    cd11304
    Location:164 → 265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80 → 158
    CA; Cadherin repeats
    pfam01049
    Location:638 → 785
    Cadherin_C; Cadherin cytoplasmic region

  2. XM_036159314.1 → XP_036015207.1  cadherin-12 isoform X1

    UniProtKB/Swiss-Prot
    Q5RJH3
    Conserved Domains (3) summary
    cd11304
    Location:164 → 265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80 → 158
    CA; Cadherin repeats
    pfam01049
    Location:638 → 785
    Cadherin_C; Cadherin cytoplasmic region

  3. XM_011245342.4 → XP_011243644.1  cadherin-12 isoform X1

    See identical proteins and their annotated locations for XP_011243644.1

    UniProtKB/Swiss-Prot
    Q5RJH3
    Conserved Domains (3) summary
    cd11304
    Location:164 → 265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80 → 158
    CA; Cadherin repeats
    pfam01049
    Location:638 → 785
    Cadherin_C; Cadherin cytoplasmic region

  4. XM_011245345.4 → XP_011243647.1  cadherin-12 isoform X1

    See identical proteins and their annotated locations for XP_011243647.1

    UniProtKB/Swiss-Prot
    Q5RJH3
    Conserved Domains (3) summary
    cd11304
    Location:164 → 265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80 → 158
    CA; Cadherin repeats
    pfam01049
    Location:638 → 785
    Cadherin_C; Cadherin cytoplasmic region

  5. XM_011245341.4 → XP_011243643.1  cadherin-12 isoform X1

    See identical proteins and their annotated locations for XP_011243643.1

    UniProtKB/Swiss-Prot
    Q5RJH3
    Conserved Domains (3) summary
    cd11304
    Location:164 → 265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80 → 158
    CA; Cadherin repeats
    pfam01049
    Location:638 → 785
    Cadherin_C; Cadherin cytoplasmic region

  6. XM_017316546.3 → XP_017172035.1  cadherin-12 isoform X1

    UniProtKB/Swiss-Prot
    Q5RJH3
    Conserved Domains (3) summary
    cd11304
    Location:164 → 265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80 → 158
    CA; Cadherin repeats
    pfam01049
    Location:638 → 785
    Cadherin_C; Cadherin cytoplasmic region

  7. XM_030248459.2 → XP_030104319.1  cadherin-12 isoform X2

    Conserved Domains (2) summary
    cd11304
    Location:102 → 209
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:467 → 614
    Cadherin_C; Cadherin cytoplasmic region

  8. XM_011245343.4 → XP_011243645.1  cadherin-12 isoform X1

    See identical proteins and their annotated locations for XP_011243645.1

    UniProtKB/Swiss-Prot
    Q5RJH3
    Conserved Domains (3) summary
    cd11304
    Location:164 → 265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80 → 158
    CA; Cadherin repeats
    pfam01049
    Location:638 → 785
    Cadherin_C; Cadherin cytoplasmic region

  9. XM_017316545.1 → XP_017172034.1  cadherin-12 isoform X1

    UniProtKB/Swiss-Prot
    Q5RJH3
    Conserved Domains (3) summary
    cd11304
    Location:164 → 265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80 → 158
    CA; Cadherin repeats
    pfam01049
    Location:638 → 785
    Cadherin_C; Cadherin cytoplasmic region

  10. XM_017316547.3 → XP_017172036.1  cadherin-12 isoform X2

    Conserved Domains (2) summary
    cd11304
    Location:102 → 209
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:467 → 614
    Cadherin_C; Cadherin cytoplasmic region

  11. XM_011245347.4 → XP_011243649.1  cadherin-12 isoform X1

    See identical proteins and their annotated locations for XP_011243649.1

    UniProtKB/Swiss-Prot
    Q5RJH3
    Conserved Domains (3) summary
    cd11304
    Location:164 → 265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80 → 158
    CA; Cadherin repeats
    pfam01049
    Location:638 → 785
    Cadherin_C; Cadherin cytoplasmic region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RJH3.1 GenPept UniProtKB/Swiss-Prot:Q5RJH3

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