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Rassf2 Ras association (RalGDS/AF-6) domain family member 2 [ Mus musculus (house mouse) ]

Gene ID: 215653, updated on 11-Apr-2024

Summary

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Official Symbol
Rassf2provided by MGI
Official Full Name
Ras association (RalGDS/AF-6) domain family member 2provided by MGI
Primary source
MGI:MGI:2442060
See related
Ensembl:ENSMUSG00000027339 AllianceGenome:MGI:2442060
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3830431H01Rik; 9030412M04Rik
Summary
Predicted to enable protein kinase activity. Acts upstream of or within several processes, including epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade; negative regulation of NIK/NF-kappaB signaling; and regulation of osteoclast differentiation. Located in cytoplasm and nucleus. Is expressed in central nervous system; heart valve; and urinary system. Orthologous to human RASSF2 (Ras association domain family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 18.3), spleen adult (RPKM 16.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 F2; 2 64.14 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (131834770..131872336, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (131992850..132030416, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05721 Neighboring gene STARR-seq mESC enhancer starr_05722 Neighboring gene prion protein Neighboring gene prion protein readthrough transcript Neighboring gene STARR-seq mESC enhancer starr_05723 Neighboring gene prion like protein doppel Neighboring gene STARR-positive B cell enhancer mm9_chr2:131844916-131845217 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131846634-131846817 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131855025-131855212 Neighboring gene STARR-positive B cell enhancer ABC_E9533 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131861333-131861539 Neighboring gene predicted gene, 31179 Neighboring gene STARR-positive B cell enhancer ABC_E5986 Neighboring gene solute carrier family 23 (nucleobase transporters), member 2 Neighboring gene STARR-positive B cell enhancer ABC_E10148 Neighboring gene STARR-positive B cell enhancer ABC_E8794 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice. Song H, et al. EMBO J, 2012 Mar 7. PMID 22227519, Free PMC Article
  2. Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity. Song H, et al. Biochem Biophys Res Commun, 2010 Jan 1. PMID 19962960
  3. Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs. MacLaren EJ, et al. Mamm Genome, 2006 Feb. PMID 16465594, Free PMC Article
  4. Atlas of gene expression in the developing kidney at microanatomic resolution. Brunskill EW, et al. Dev Cell, 2008 Nov. PMID 19000842, Free PMC Article
  5. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within bone remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of non-canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within ossification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of non-canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of non-canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
ras association domain-containing protein 2
Names
Ras association (RalGDS/AF-6) domain family 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362866.1 → NP_001349795.1  ras association domain-containing protein 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL833794, AL929513
    Consensus CDS
    CCDS16768.1
    UniProtKB/Swiss-Prot
    Q6A0B2, Q8BMS9
    Related
    ENSMUSP00000099471.2, ENSMUST00000103182.8
    Conserved Domains (2) summary
    cd17221
    Location:177 → 263
    RA_RASSF2; Ras-associating (RA) domain found in Ras-association domain-containing protein 2 (RASSF2)
    pfam16517
    Location:277 → 316
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

  2. NM_175445.4 → NP_780654.1  ras association domain-containing protein 2

    See identical proteins and their annotated locations for NP_780654.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL833794, BC057402, BQ770520
    Consensus CDS
    CCDS16768.1
    UniProtKB/Swiss-Prot
    Q6A0B2, Q8BMS9
    Related
    ENSMUSP00000028814.9, ENSMUST00000028814.15
    Conserved Domains (2) summary
    cd17221
    Location:177 → 263
    RA_RASSF2; Ras-associating (RA) domain found in Ras-association domain-containing protein 2 (RASSF2)
    pfam16517
    Location:277 → 316
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    131834770..131872336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499140.4 → XP_006499203.1  ras association domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006499203.1

    UniProtKB/Swiss-Prot
    Q6A0B2, Q8BMS9
    Conserved Domains (2) summary
    cd17221
    Location:177 → 263
    RA_RASSF2; Ras-associating (RA) domain found in Ras-association domain-containing protein 2 (RASSF2)
    pfam16517
    Location:277 → 316
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

  2. XM_006499139.5 → XP_006499202.1  ras association domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006499202.1

    UniProtKB/Swiss-Prot
    Q6A0B2, Q8BMS9
    Conserved Domains (2) summary
    cd17221
    Location:177 → 263
    RA_RASSF2; Ras-associating (RA) domain found in Ras-association domain-containing protein 2 (RASSF2)
    pfam16517
    Location:277 → 316
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

  3. XM_006499144.5 → XP_006499207.1  ras association domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006499207.1

    UniProtKB/Swiss-Prot
    Q6A0B2, Q8BMS9
    Conserved Domains (2) summary
    cd17221
    Location:177 → 263
    RA_RASSF2; Ras-associating (RA) domain found in Ras-association domain-containing protein 2 (RASSF2)
    pfam16517
    Location:277 → 316
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

  4. XM_006499141.4 → XP_006499204.1  ras association domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006499204.1

    UniProtKB/Swiss-Prot
    Q6A0B2, Q8BMS9
    Conserved Domains (2) summary
    cd17221
    Location:177 → 263
    RA_RASSF2; Ras-associating (RA) domain found in Ras-association domain-containing protein 2 (RASSF2)
    pfam16517
    Location:277 → 316
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BMS9.1 GenPept UniProtKB/Swiss-Prot:Q8BMS9

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