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Zbtb8b zinc finger and BTB domain containing 8b [ Mus musculus (house mouse) ]

Gene ID: 215627, updated on 11-Apr-2024

Summary

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Official Symbol
Zbtb8bprovided by MGI
Official Full Name
zinc finger and BTB domain containing 8bprovided by MGI
Primary source
MGI:MGI:2387181
See related
Ensembl:ENSMUSG00000048485 AllianceGenome:MGI:2387181
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BOZF1; Zbtb8
Summary
Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus; eye; and genitourinary system. Orthologous to human ZBTB8B (zinc finger and BTB domain containing 8B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 1.9), whole brain E14.5 (RPKM 1.2) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 63.26 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129320063..129340761, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129425765..129446969, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 8a Neighboring gene STARR-seq mESC enhancer starr_11489 Neighboring gene STARR-seq mESC enhancer starr_11490 Neighboring gene RIKEN cDNA C330020E22 gene Neighboring gene STARR-seq mESC enhancer starr_11493 Neighboring gene STARR-seq mESC enhancer starr_11495 Neighboring gene STARR-positive B cell enhancer ABC_E11256 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129138525-129138708 Neighboring gene predicted gene, 24621 Neighboring gene BSD domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
  2. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
  3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC38362

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 8B
Names
zinc finger and BTB domain containing 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153541.4 → NP_705769.2  zinc finger and BTB domain-containing protein 8B

    See identical proteins and their annotated locations for NP_705769.2

    Status: VALIDATED

    Source sequence(s)
    AL606921
    Consensus CDS
    CCDS18691.1
    UniProtKB/Swiss-Prot
    Q3US18, Q8CII0
    UniProtKB/TrEMBL
    A0A0R4J0Q8
    Related
    ENSMUSP00000058157.6, ENSMUST00000053042.6
    Conserved Domains (4) summary
    smart00225
    Location:25 → 122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:333 → 353
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:14 → 118
    BTB; BTB/POZ domain
    pfam13465
    Location:346 → 370
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    129320063..129340761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240481.4 → XP_011238783.1  zinc finger and BTB domain-containing protein 8B isoform X1

    See identical proteins and their annotated locations for XP_011238783.1

    UniProtKB/Swiss-Prot
    Q3US18, Q8CII0
    UniProtKB/TrEMBL
    I7HLR7
    Conserved Domains (4) summary
    sd00017
    Location:366 → 386
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18330
    Location:39 → 151
    BTB_POZ_ZBTB8B; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B)
    pfam13465
    Location:379 → 403
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:364 → 388
    zf-H2C2_5; C2H2-type zinc-finger domain

  2. XM_017320102.3 → XP_017175591.1  zinc finger and BTB domain-containing protein 8B isoform X1

    UniProtKB/Swiss-Prot
    Q3US18, Q8CII0
    UniProtKB/TrEMBL
    I7HLR7
    Conserved Domains (4) summary
    sd00017
    Location:366 → 386
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18330
    Location:39 → 151
    BTB_POZ_ZBTB8B; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B)
    pfam13465
    Location:379 → 403
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:364 → 388
    zf-H2C2_5; C2H2-type zinc-finger domain

  3. XM_036163954.1 → XP_036019847.1  zinc finger and BTB domain-containing protein 8B isoform X1

    UniProtKB/Swiss-Prot
    Q3US18, Q8CII0
    UniProtKB/TrEMBL
    I7HLR7
    Related
    ENSMUSP00000101661.2, ENSMUST00000106046.8
    Conserved Domains (4) summary
    sd00017
    Location:366 → 386
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18330
    Location:39 → 151
    BTB_POZ_ZBTB8B; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B)
    pfam13465
    Location:379 → 403
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:364 → 388
    zf-H2C2_5; C2H2-type zinc-finger domain

  4. XM_006502927.4 → XP_006502990.1  zinc finger and BTB domain-containing protein 8B isoform X1

    See identical proteins and their annotated locations for XP_006502990.1

    UniProtKB/Swiss-Prot
    Q3US18, Q8CII0
    UniProtKB/TrEMBL
    I7HLR7
    Conserved Domains (4) summary
    sd00017
    Location:366 → 386
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18330
    Location:39 → 151
    BTB_POZ_ZBTB8B; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B)
    pfam13465
    Location:379 → 403
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:364 → 388
    zf-H2C2_5; C2H2-type zinc-finger domain

  5. XM_017320101.2 → XP_017175590.1  zinc finger and BTB domain-containing protein 8B isoform X1

    UniProtKB/Swiss-Prot
    Q3US18, Q8CII0
    UniProtKB/TrEMBL
    I7HLR7
    Conserved Domains (4) summary
    sd00017
    Location:366 → 386
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18330
    Location:39 → 151
    BTB_POZ_ZBTB8B; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B)
    pfam13465
    Location:379 → 403
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:364 → 388
    zf-H2C2_5; C2H2-type zinc-finger domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CII0.1 GenPept UniProtKB/Swiss-Prot:Q8CII0

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