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A3galt2 alpha 1,3-galactosyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 215493, updated on 5-Mar-2024

Summary

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Official Symbol
A3galt2provided by MGI
Official Full Name
alpha 1,3-galactosyltransferase 2provided by MGI
Primary source
MGI:MGI:2685279
See related
Ensembl:ENSMUSG00000028794 AllianceGenome:MGI:2685279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
iGb3; Gm433; iGb3S
Summary
Enables alpha-1,3-galactosyltransferase activity. Acts upstream of or within glycosphingolipid biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and vesicle. Orthologous to human A3GALT2 (alpha 1,3-galactosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 1.3), CNS E14 (RPKM 1.1) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 62.23 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (128653051..128663091)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (128759258..128769298)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11455 Neighboring gene predicted gene 12958 Neighboring gene STARR-positive B cell enhancer ABC_E9239 Neighboring gene polyhomeotic 2 Neighboring gene STARR-positive B cell enhancer ABC_E6219 Neighboring gene VISTA enhancer mm1684 Neighboring gene STARR-seq mESC enhancer starr_11460 Neighboring gene predicted gene, 33712 Neighboring gene STARR-positive B cell enhancer ABC_E9595 Neighboring gene STARR-positive B cell enhancer ABC_E3514 Neighboring gene zinc finger protein 362 Neighboring gene STARR-seq mESC enhancer starr_11464 Neighboring gene predicted gene, 52679 Neighboring gene STARR-positive B cell enhancer ABC_E6220 Neighboring gene STARR-seq mESC enhancer starr_11466 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency. Porubsky S, et al. Proc Natl Acad Sci U S A, 2007 Apr 3. PMID 17372206, Free PMC Article
  2. [Glycosphingolipids Gb3 and iGb3. In vivo roles in hemolytic-uremic syndrome and iNKT cell function]. Porubsky S, et al. Pathologe, 2008 Nov. PMID 18810447
  3. Aggression in cataract-bearing alpha-1,3-galactosyltransferase knockout mice. Sørensen DB, et al. Lab Anim, 2008 Jan. PMID 18348765
  4. The molecular basis for galalpha(1,3)gal expression in animals with a deletion of the alpha1,3galactosyltransferase gene. Milland J, et al. J Immunol, 2006 Feb 15. PMID 16456004
  5. Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins. Okuda T, et al. J Biol Chem, 2006 Apr 14. PMID 16476743

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular cloning and functional analysis of mouse iGb3 synthase in mouse thymus, with its enzyme-synthesized product verified by NMR spectrum.
    Title: Lysosomal glycosphingolipid recognition by NKT cells.
  2. Investigation in vivo the previously implicated function of iGb3 as the endogenous lipid ligand responsible for positive selection of invariant natural killer T-cells.
    Title: [Glycosphingolipids Gb3 and iGb3. In vivo roles in hemolytic-uremic syndrome and iNKT cell function].
  3. A study evaluating aggressive behavior associated with cataract formation in mice with a knockout at this enzyme site is reported.
    Title: Aggression in cataract-bearing alpha-1,3-galactosyltransferase knockout mice.
  4. Invariant natural killer T cells with A3galt2 deficiency had normal development and function.
    Title: Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyllactosaminide 3-alpha-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables alpha-1,3-galactosyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables alpha-1,3-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to manganese ion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glycosphingolipid biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within glycosphingolipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosphingolipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid glycosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-1,3-galactosyltransferase 2
Names
alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase)
iGb3 synthase
NP_001009819.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009819.2 → NP_001009819.1  alpha-1,3-galactosyltransferase 2

    See identical proteins and their annotated locations for NP_001009819.1

    Status: VALIDATED

    Source sequence(s)
    AK132334
    Consensus CDS
    CCDS18675.1
    UniProtKB/Swiss-Prot
    B2KGX5, B2KGX6, M9MMK2, Q3V1N9
    Related
    ENSMUSP00000030585.8, ENSMUST00000030585.8
    Conserved Domains (1) summary
    cd02515
    Location:98 → 369
    Glyco_transf_6; Glycosyltransferase family 6 comprises enzymes responsible for the production of the human ABO blood group antigens

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    128653051..128663091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V1N9.1 GenPept UniProtKB/Swiss-Prot:Q3V1N9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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