Entpd3 ectonucleoside triphosphate diphosphohydrolase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Entpd3provided by MGI
Official Full Name: ectonucleoside triphosphate diphosphohydrolase 3provided by MGI
Primary source: MGI:MGI:1321386
See related: Ensembl:ENSMUSG00000041608 AllianceGenome:MGI:1321386
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HB6; Cd39l3; NTPDase-3
Summary: Enables nucleoside-diphosphatase activity and nucleoside-triphosphatase activity. Acts upstream of or within nucleoside diphosphate catabolic process and nucleoside triphosphate catabolic process. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and skeleton. Orthologous to human ENTPD3 (ectonucleoside triphosphate diphosphohydrolase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 19.5), adrenal adult (RPKM 4.4) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F4; 9 71.71 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (120368884..120397393)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (120539818..120568327)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism.
Title: Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism.
NTPDase2 and -3 are ecto-enzymes expressed in the enteric nervous system. Both enzymes confer protection against gut inflammation in experimental colitis and exhibit alterations in Crohn's disease. These observations suggest that purinergic signalling modulated by E-NTPDases governs neuro-immune interactions that are relevant in Crohn's disease.
Title: Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease.
Results identified the expression of ecto-NTPDase3 in trigeminal nociceptive neurons and demonstrated the presence of functional ecto-ATPase activity in trigeminal nerves and established that ecto-NTPDase3mediates extracellularATP degradation in the nociceptive lamina on the brainstem.
Title: Neuronal NTPDase3 Mediates Extracellular ATP Degradation in Trigeminal Nociceptive Pathway.
Mesenteric endothelial cells are primed by schistosomiasis to a pro-inflammatory phenotype characterized by an increased expression of NTPDases 2 and 3, favoring ADP accumulation and mononuclear cell adhesion, possibly contributing to mesenteric inflammation and schistosomiasis morbidity via P2Y1 receptor signaling.
Title: Increased expression of NTPDases 2 and 3 in mesenteric endothelial cells during schistosomiasis favors leukocyte adhesion through P2Y1 receptors.
In bladder cancer disease progression there was a weak immunostaining to NTPDase in bladder samples.
Title: NTPDase3 and ecto-5'-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression.
NTPDase3 is the major ectonucleotidase in pancreatic beta-cells in multiple species and modulates insulin secretion by controlling activation of purinergic receptors.
Title: Ectonucleotidase NTPDase3 is abundant in pancreatic β-cells and regulates glucose-induced insulin secretion.
The results of this study proposeed that NTPDase3 is a key regulator of nociceptive signaling that also makes an unexpected contribution to innocuous tactile sensation.
Title: Distribution of ecto-nucleotidases in mouse sensory circuits suggests roles for nucleoside triphosphate diphosphohydrolase-3 in nociception and mechanoreception.
the specific localization of NTPDase3 in the digestive system suggests functional roles of the enzyme, in association with NTPDase2 and ecto-5'-nucleotidase, in epithelial functions such as secretion and in enteric neurotransmission.
Title: Ectonucleotidases in the digestive system: focus on NTPDase3 localization.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables 5'-nucleotidase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables apyrase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleoside diphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables ribonucleoside triphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoside triphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribonucleoside triphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in nucleoside diphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nucleoside diphosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nucleoside triphosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ectonucleoside triphosphate diphosphohydrolase 3

Names: CD39 antigen-like 3; NTPDase 3; ecto-ATP diphosphohydrolase 3; ecto-ATPDase 3; ecto-ATPase 3

NP_848791.3

EC 3.6.1.5

XP_036010724.1

EC 3.6.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178676.5 → NP_848791.3 ectonucleoside triphosphate diphosphohydrolase 3

Status: VALIDATED

Source sequence(s)

AI854406, AK046218, BB580245, BY595885

Consensus CDS

CCDS23629.1

UniProtKB/Swiss-Prot

E9PYV0, Q3TC04, Q3TDX3, Q8BFW6

Related

ENSMUSP00000036830.8, ENSMUST00000047687.9

Conserved Domains (1) summary

cl17037
Location:49 → 478

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

120368884..120397393

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154831.1 → XP_036010724.1 ectonucleoside triphosphate diphosphohydrolase 3 isoform X1

UniProtKB/TrEMBL

Q8CCV2

Conserved Domains (1) summary

cl17037
Location:1 → 337

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily