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Rab11fip3 RAB11 family interacting protein 3 (class II) [ Mus musculus (house mouse) ]

Gene ID: 215445, updated on 11-Apr-2024

Summary

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Official Symbol
Rab11fip3provided by MGI
Official Full Name
RAB11 family interacting protein 3 (class II)provided by MGI
Primary source
MGI:MGI:2444431
See related
Ensembl:ENSMUSG00000037098 AllianceGenome:MGI:2444431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FIP3; Cart1; mKIAA0665; Rab11-FIP3; D030060O14Rik
Summary
Predicted to enable dynein light intermediate chain binding activity; protein homodimerization activity; and small GTPase binding activity. Acts upstream of or within protein localization to cilium. Located in membrane. Is expressed in several structures, including gonad; gut; immune system; liver; and retina. Orthologous to human RAB11FIP3 (RAB11 family interacting protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 86.1), frontal lobe adult (RPKM 15.3) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Rab11fip3 in Genome Data Viewer
Location:
17 A3.3; 17 13.05 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26208010..26289010, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25989036..26070077, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA gene D630044L22 gene Neighboring gene proline rich 35 Neighboring gene calpain 15 Neighboring gene RIKEN cDNA 1700022N22 gene Neighboring gene STARR-positive B cell enhancer ABC_E1937 Neighboring gene STARR-seq mESC enhancer starr_42116 Neighboring gene membrane-associated ring finger (C3HC4) 5 pseudogene Neighboring gene 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FIP4/Arfophilin-2 plays overlapping but distinct roles from FIP3/Arfophilin-1 in neuronal migration during cortical layer formation. Hara Y, et al. Eur J Neurosci, 2018 Nov. PMID 30295969
  2. IFN-γ/mTORC1 decreased Rab11 in Schwann cells of diabetic peripheral neuropathy, inhibiting cell proliferation via GLUT1 downregulation. Du W, et al. J Cell Physiol, 2020 Jul. PMID 31970777
  3. ADP Ribosylation Factor 6 Regulates Neuronal Migration in the Developing Cerebral Cortex through FIP3/Arfophilin-1-dependent Endosomal Trafficking of N-cadherin. Hara Y, et al. eNeuro, 2016 Jul-Aug. PMID 27622210, Free PMC Article
  4. Mouse Rab11-FIP4 regulates proliferation and differentiation of retinal progenitors in a Rab11-independent manner. Muto A, et al. Dev Dyn, 2007 Jan. PMID 17089410
  5. A novel cytoplasmic adaptor for retinoic acid receptor (RAR) and thyroid receptor functions as a Derepressor of RAR in the absence of retinoic acid. Park UH, et al. J Biol Chem, 2010 Oct 29. PMID 20736163, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IFN-gamma/mTORC1 decreased Rab11 in Schwann cells of diabetic peripheral neuropathy, inhibiting cell proliferation via GLUT1 downregulation.
    Title: IFN-γ/mTORC1 decreased Rab11 in Schwann cells of diabetic peripheral neuropathy, inhibiting cell proliferation via GLUT1 downregulation.
  2. FIP3 and FIP4 play overlapping but distinct roles in neuronal migration downstream of Rab11 and Arfophilin-1 during cortical layer formation.
    Title: FIP4/Arfophilin-2 plays overlapping but distinct roles from FIP3/Arfophilin-1 in neuronal migration during cortical layer formation.
  3. Results suggest that FIP3 regulates dendritic formation in the hippocampus possibly through Rab11- and Arf6-mediated endosomal trafficking
    Title: Endosomal localization of FIP3/Arfophilin-1 and its involvement in dendritic formation of mouse hippocampal neurons.
  4. CART1 might be a cytoplasmic, testis-specific derepressor of RAR [CART1, cytoplasmic adaptor for RAR and TR]
    Title: A novel cytoplasmic adaptor for retinoic acid receptor (RAR) and thyroid receptor functions as a Derepressor of RAR in the absence of retinoic acid.
  5. Fip3 and Rab11 protein complex regulates recycling endosomes targeting to the cleavage furrow during late cytokinesis.
    Title: The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC47508

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables dynein light intermediate chain binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in early endosome to recycling endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of adiponectin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitotic cytokinetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to cilium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to cilium ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of early endosome to recycling endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endocytic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic recycling endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in recycling endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rab11 family-interacting protein 3
Names
FIP3-Rab11
cytoplasmic adaptor for RAR and TR
NP_001156340.1
NP_001156341.1
NP_694780.1
XP_011244664.1
XP_036016358.1
XP_036016359.1
XP_036016360.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162868.2 → NP_001156340.1  rab11 family-interacting protein 3 isoform b

    See identical proteins and their annotated locations for NP_001156340.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1, that results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC140047, AC159277
    Consensus CDS
    CCDS50040.1
    UniProtKB/Swiss-Prot
    Q8CHD8, Q8JZT3
    Related
    ENSMUSP00000112875.2, ENSMUST00000120691.9
    Conserved Domains (7) summary
    cd00051
    Location:500 → 557
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09457
    Location:1007 → 1047
    RBD-FIP; FIP domain
    pfam05700
    Location:770 → 880
    BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
    pfam07926
    Location:831 → 979
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam13499
    Location:501 → 557
    EF-hand_7; EF-hand domain pair
    pfam14077
    Location:938 → 981
    WD40_alt; Alternative WD40 repeat motif
    cl00143
    Location:831 → 933
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

  2. NM_001162869.2 → NP_001156341.1  rab11 family-interacting protein 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC140047, AC159277
    Consensus CDS
    CCDS50041.1
    UniProtKB/Swiss-Prot
    Q8CHD8
    Related
    ENSMUSP00000113521.2, ENSMUST00000122103.9
    Conserved Domains (7) summary
    cd00051
    Location:500 → 557
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09457
    Location:1052 → 1092
    RBD-FIP; FIP domain
    pfam05700
    Location:815 → 925
    BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
    pfam07926
    Location:876 → 1024
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam13499
    Location:501 → 557
    EF-hand_7; EF-hand domain pair
    pfam14077
    Location:983 → 1026
    WD40_alt; Alternative WD40 repeat motif
    cl00143
    Location:876 → 978
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

  3. NM_153140.2 → NP_694780.1  rab11 family-interacting protein 3 isoform c

    See identical proteins and their annotated locations for NP_694780.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a distinct 5' UTR and lacks many exons of the 5' coding region, compared to variant 1, that results in a protein (isoform c) that starts from an internal methionine, compared to isoform a.
    Source sequence(s)
    AK083658, AK085516, BE853781, BM114891, CB840427, CF170100, CF747684
    Consensus CDS
    CCDS50039.1
    UniProtKB/Swiss-Prot
    Q8CHD8
    Related
    ENSMUSP00000113048.2, ENSMUST00000118828.8
    Conserved Domains (3) summary
    pfam09457
    Location:404 → 444
    RBD-FIP; FIP domain
    pfam05700
    Location:167 → 277
    BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
    cl19219
    Location:251 → 330
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    26208010..26289010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160467.1 → XP_036016360.1  rab11 family-interacting protein 3 isoform X3

    Conserved Domains (3) summary
    PTZ00449
    Location:12 → 331
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    COG1196
    Location:796 → 1059
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13499
    Location:500 → 557
    EF-hand_7; EF-hand domain pair

  2. XM_036160466.1 → XP_036016359.1  rab11 family-interacting protein 3 isoform X2

    Conserved Domains (3) summary
    PTZ00449
    Location:12 → 331
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    COG1196
    Location:808 → 1071
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13499
    Location:500 → 557
    EF-hand_7; EF-hand domain pair

  3. XM_036160465.1 → XP_036016358.1  rab11 family-interacting protein 3 isoform X1

    Conserved Domains (3) summary
    PTZ00449
    Location:12 → 331
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    COG1196
    Location:853 → 1116
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13499
    Location:500 → 557
    EF-hand_7; EF-hand domain pair

  4. XM_011246362.4 → XP_011244664.1  rab11 family-interacting protein 3 isoform X4

    Conserved Domains (2) summary
    PTZ00449
    Location:12 → 331
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam13499
    Location:500 → 557
    EF-hand_7; EF-hand domain pair

RNA

  1. XR_876466.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CHD8.2 GenPept UniProtKB/Swiss-Prot:Q8CHD8

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