Fcgbp Fc fragment of IgG binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fcgbpprovided by MGI
Official Full Name: Fc fragment of IgG binding proteinprovided by MGI
Primary source: MGI:MGI:2444336
See related: Ensembl:ENSMUSG00000047730 AllianceGenome:MGI:2444336
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A430096B05Rik
Summary: Located in extracellular matrix. Is expressed in genitourinary system; gut; immune system; and integumental system. Orthologous to human FCGBP (Fc fragment of IgG binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 684.9), large intestine adult (RPKM 495.9) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 16.26 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (27770661..27820289)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (28071236..28120864)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gkn3, Fcgbp, and Muc2 might be involved in the transient disruption of the splenic architecture and its reorganization, which is characteristic after Toxoplasma gondii infection.
Title: Transcriptional Responses in the Murine Spleen after Toxoplasma gondii Infection: Inflammasome and Mucus-Associated Genes.
the Fcgbp protein is probably cleaved at GD/PH and covalently attached to Muc2 via one or several of its von Willebrand D domains
Title: Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: IgGFc-binding protein

Names: IgG Fc binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122603.1 → NP_001116075.1 IgGFc-binding protein precursor

Status: VALIDATED

Source sequence(s)

AC158220, AJ011416, AK040441, AK077773, EH108930

Consensus CDS

CCDS52159.1

UniProtKB/TrEMBL

E9Q0B5, E9Q9C6

Related

ENSMUSP00000075945.8, ENSMUST00000076648.8

Conserved Domains (5) summary

smart00832
Location:1034 → 1109

C8; This domain contains 8 conserved cysteine residues

pfam00094
Location:56 → 210

VWD; von Willebrand factor type D domain

pfam01826
Location:1917 → 1970

TIL; Trypsin Inhibitor like cysteine rich domain

cl02516
Location:2413 → 2567

VWD; von Willebrand factor type D domain

cl17735
Location:778 → 829

VWC; von Willebrand factor type C domain