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Senp6 SUMO/sentrin specific peptidase 6 [ Mus musculus (house mouse) ]

Gene ID: 215351, updated on 13-Apr-2024

Summary

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Official Symbol
Senp6provided by MGI
Official Full Name
SUMO/sentrin specific peptidase 6provided by MGI
Primary source
MGI:MGI:1922075
See related
Ensembl:ENSMUSG00000034252 AllianceGenome:MGI:1922075
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Susp1; mKIAA0797; 2810017C20Rik; E130319N12Rik
Summary
Predicted to enable SUMO-specific endopeptidase activity. Predicted to be involved in protein desumoylation; regulation of kinetochore assembly; and regulation of spindle assembly. Predicted to act upstream of or within proteolysis. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in embryo. Orthologous to human SENP6 (SUMO specific peptidase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 16.8), CNS E14 (RPKM 11.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 E1; 9 43.88 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (79973862..80052064)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (80066575..80144782)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene filamin A interacting protein 1 Neighboring gene predicted gene, 53505 Neighboring gene STARR-seq mESC enhancer starr_24749 Neighboring gene STARR-seq mESC enhancer starr_24751 Neighboring gene STARR-seq mESC enhancer starr_24752 Neighboring gene STARR-seq mESC enhancer starr_24753 Neighboring gene STARR-seq mESC enhancer starr_24754 Neighboring gene STARR-positive B cell enhancer ABC_E715 Neighboring gene 5'-nucleotidase domain containing 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8303 Neighboring gene predicted gene, 46146 Neighboring gene STARR-positive B cell enhancer ABC_E3848 Neighboring gene myosin VI Neighboring gene predicted gene 27227 Neighboring gene STARR-seq mESC enhancer starr_24757 Neighboring gene interphotoreceptor matrix proteoglycan 1 Neighboring gene methyltransferase like 9 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway. Li J, et al. Nat Commun, 2018 Jan 10. PMID 29321472, Free PMC Article
  2. Inhibition of SENP6 restrains cerebral ischemia-reperfusion injury by regulating Annexin-A1 nuclear translocation-associated neuronal apoptosis. Xia Q, et al. Theranostics, 2021. PMID 34158860, Free PMC Article
  3. Negative regulation of TLR inflammatory signaling by the SUMO-deconjugating enzyme SENP6. Liu X, et al. PLoS Pathog, 2013. PMID 23825957, Free PMC Article
  4. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
  5. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of SENP6 restrains cerebral ischemia-reperfusion injury by regulating Annexin-A1 nuclear translocation-associated neuronal apoptosis.
    Title: Inhibition of SENP6 restrains cerebral ischemia-reperfusion injury by regulating Annexin-A1 nuclear translocation-associated neuronal apoptosis.
  2. postnatal loss of the desumoylase SUMO1/sentrin-specific peptidase 6 (SENP6) causes premature aging. OCP-specific SENP6 knockout mice exhibit smaller skeletons, with elevated apoptosis and cell senescence in OCPs and chondrocytes. SENP6 interacts with, desumoylates, and stabilizes TRIM28, suppressing p53 activity.
    Title: Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway.
  3. Negative regulation of TLR inflammatory signaling by the SUMO-deconjugating enzyme SENP6.
    Title: Negative regulation of TLR inflammatory signaling by the SUMO-deconjugating enzyme SENP6.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38009

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SUMO-specific endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO-specific endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein desumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein desumoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein modification by small protein removal ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of kinetochore assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of kinetochore assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of spindle assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sentrin-specific protease 6
Names
SUMO-1-specific protease 1
SUMO/sentrin specific protease 6
sentrin/SUMO-specific protease SENP6
NP_001298039.1
NP_666115.2
XP_006511077.1
XP_006511078.1
XP_006511079.1
XP_006511080.1
XP_030100089.1
XP_030100090.1
XP_036010718.1
XP_036010719.1
XP_036010720.1
XP_036010721.1
XP_036010722.1
XP_036010723.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311110.1 → NP_001298039.1  sentrin-specific protease 6 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK053904, AK083377, BC052718
    Consensus CDS
    CCDS81040.1
    UniProtKB/TrEMBL
    B7ZWN9, F6Z9A1
    Related
    ENSMUSP00000126777.3, ENSMUST00000165607.9
    Conserved Domains (1) summary
    cl23802
    Location:707 → 819
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  2. NM_146003.2 → NP_666115.2  sentrin-specific protease 6 isoform 2

    See identical proteins and their annotated locations for NP_666115.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK028461, AK048485, AK053904, AK083377
    Consensus CDS
    CCDS40705.1
    UniProtKB/Swiss-Prot
    E9QN09, Q6P7W0, Q6ZQ43, Q8BK94, Q8BUL4
    UniProtKB/TrEMBL
    B7ZWN9
    Related
    ENSMUSP00000047220.9, ENSMUST00000037484.15
    Conserved Domains (1) summary
    cl23802
    Location:700 → 812
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    79973862..80052064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511016.5 → XP_006511079.1  sentrin-specific protease 6 isoform X4

    UniProtKB/TrEMBL
    B7ZWN9
    Conserved Domains (2) summary
    COG5160
    Location:513 → 624
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    cl23802
    Location:822 → 898
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  2. XM_036154825.1 → XP_036010718.1  sentrin-specific protease 6 isoform X3

    UniProtKB/TrEMBL
    B7ZWN9
    Conserved Domains (2) summary
    COG5160
    Location:564 → 675
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    cl23802
    Location:873 → 949
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  3. XM_006511017.5 → XP_006511080.1  sentrin-specific protease 6 isoform X5

    UniProtKB/TrEMBL
    B7ZWN9
    Conserved Domains (2) summary
    COG5160
    Location:506 → 617
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    cl23802
    Location:815 → 891
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  4. XM_006511014.3 → XP_006511077.1  sentrin-specific protease 6 isoform X1

    See identical proteins and their annotated locations for XP_006511077.1

    UniProtKB/TrEMBL
    B7ZWN9
    Conserved Domains (2) summary
    COG5160
    Location:583 → 694
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    cl23802
    Location:892 → 968
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  5. XM_036154827.1 → XP_036010720.1  sentrin-specific protease 6 isoform X3

    UniProtKB/TrEMBL
    B7ZWN9
    Conserved Domains (2) summary
    COG5160
    Location:564 → 675
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    cl23802
    Location:873 → 949
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  6. XM_030244229.2 → XP_030100089.1  sentrin-specific protease 6 isoform X2

    UniProtKB/TrEMBL
    B7ZWN9
    Conserved Domains (2) summary
    COG5160
    Location:576 → 687
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    cl23802
    Location:885 → 961
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  7. XM_036154826.1 → XP_036010719.1  sentrin-specific protease 6 isoform X3

    UniProtKB/TrEMBL
    B7ZWN9
    Conserved Domains (2) summary
    COG5160
    Location:564 → 675
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    cl23802
    Location:873 → 949
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  8. XM_006511015.5 → XP_006511078.1  sentrin-specific protease 6 isoform X1

    See identical proteins and their annotated locations for XP_006511078.1

    UniProtKB/TrEMBL
    B7ZWN9
    Conserved Domains (2) summary
    COG5160
    Location:583 → 694
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    cl23802
    Location:892 → 968
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  9. XM_036154828.1 → XP_036010721.1  sentrin-specific protease 6 isoform X3

    UniProtKB/TrEMBL
    B7ZWN9
    Conserved Domains (2) summary
    COG5160
    Location:564 → 675
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    cl23802
    Location:873 → 949
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  10. XM_030244230.2 → XP_030100090.1  sentrin-specific protease 6 isoform X2

    UniProtKB/TrEMBL
    B7ZWN9
    Conserved Domains (2) summary
    COG5160
    Location:576 → 687
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    cl23802
    Location:885 → 961
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  11. XM_036154830.1 → XP_036010723.1  sentrin-specific protease 6 isoform X6

    Conserved Domains (2) summary
    COG5160
    Location:399 → 510
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    cl23802
    Location:708 → 784
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  12. XM_036154829.1 → XP_036010722.1  sentrin-specific protease 6 isoform X3

    UniProtKB/TrEMBL
    B7ZWN9
    Related
    ENSMUSP00000128918.2, ENSMUST00000164859.8
    Conserved Domains (2) summary
    COG5160
    Location:564 → 675
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    cl23802
    Location:873 → 949
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_176927.2: Suppressed sequence

    Description
    NM_176927.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P7W0.3 GenPept UniProtKB/Swiss-Prot:Q6P7W0

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