Il1f10 interleukin 1 family, member 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il1f10provided by MGI
Official Full Name: interleukin 1 family, member 10provided by MGI
Primary source: MGI:MGI:2652548
See related: Ensembl:ENSMUSG00000046845 AllianceGenome:MGI:2652548
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable cytokine activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; cytokine-mediated signaling pathway; and inflammatory response to antigenic stimulus. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in extracellular space. Orthologous to human IL1F10 (interleukin 1 family member 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 16.32 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (24177095..24184236)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (24291196..24294165)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-38 attenuates myocardial ischemia-reperfusion injury by inhibiting macrophage inflammation.
Title: IL-38 attenuates myocardial ischemia-reperfusion injury by inhibiting macrophage inflammation.
Interleukin-38 promotes skin tumorigenesis in an IL-1Rrp2-dependent manner.
Title: Interleukin-38 promotes skin tumorigenesis in an IL-1Rrp2-dependent manner.
IL-38 Alleviates Inflammation in Sepsis in Mice by Inhibiting Macrophage Apoptosis and Activation of the NLRP3 Inflammasome.
Title: IL-38 Alleviates Inflammation in Sepsis in Mice by Inhibiting Macrophage Apoptosis and Activation of the NLRP3 Inflammasome.
IL-38-mediated NLRP3/caspase-1 inhibition is a disease-modifying treatment for TMJ inflammation.
Title: IL-38-mediated NLRP3/caspase-1 inhibition is a disease-modifying treatment for TMJ inflammation.
IL-38 prevents induction of trained immunity by inhibition of mTOR signaling.
Title: IL-38 prevents induction of trained immunity by inhibition of mTOR signaling.
Interleukin-38 overexpression prevents bleomycin-induced mouse pulmonary fibrosis.
Title: Interleukin-38 overexpression prevents bleomycin-induced mouse pulmonary fibrosis.
IL-38 Ablation Reduces Local Inflammation and Disease Severity in Experimental Autoimmune Encephalomyelitis.
Title: IL-38 Ablation Reduces Local Inflammation and Disease Severity in Experimental Autoimmune Encephalomyelitis.
IL-38: A novel cytokine in systemic lupus erythematosus pathogenesis.
Title: IL-38: A novel cytokine in systemic lupus erythematosus pathogenesis.
IL-38 knockout (IL-38 KO) mice show delayed disease resolution with exacerbated IL-17-mediated inflammation, which is reversed by the administration of mature IL-38 or gammadelta T cell-receptor-blocking antibodies.
Title: IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells.
IL-38 may enhance airway eosinophilic inflammation in asthma through IL-5 induction
Title: Attenuated Airway Eosinophilic Inflammations in IL-38 Knockout Mouse Model.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (5)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-1 receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response to antigenic stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-1 family member 10

Names: IL-1F10; interleukin 1 family, member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418946.1 → NP_001405875.1 interleukin-1 family member 10 isoform 1

Status: VALIDATED

Source sequence(s)

AL732430
NM_153077.3 → NP_694717.1 interleukin-1 family member 10 isoform 2

See identical proteins and their annotated locations for NP_694717.1

Status: VALIDATED

Source sequence(s)

AL732430

Consensus CDS

CCDS15735.1

UniProtKB/Swiss-Prot

Q8R459

UniProtKB/TrEMBL

Q3KNF2

Related

ENSMUSP00000063004.2, ENSMUST00000058056.2

Conserved Domains (1) summary

cl00094
Location:10 → 149

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).