U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Trmt2b TRM2 tRNA methyltransferase 2B [ Mus musculus (house mouse) ]

Gene ID: 215201, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Trmt2bprovided by MGI
Official Full Name
TRM2 tRNA methyltransferase 2Bprovided by MGI
Primary source
MGI:MGI:2442530
See related
Ensembl:ENSMUSG00000067369 AllianceGenome:MGI:2442530
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4732479N06Rik
Summary
Predicted to enable S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity. Predicted to be involved in RNA processing. Predicted to act upstream of or within methylation and tRNA processing. Located in mitochondrion. Is expressed in olfactory cortex ventricular layer and telencephalon ventricular layer. Orthologous to human TRMT2B (tRNA methyltransferase 2 homolog B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 10.8), bladder adult (RPKM 6.8) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
X E3; X 55.95 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (133123704..133177770, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (134222955..134277023, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene X-linked Kx blood group related, X-linked Neighboring gene STARR-seq mESC enhancer starr_47954 Neighboring gene ADP-ribosylation factor-like 13A Neighboring gene STARR-seq mESC enhancer starr_47955 Neighboring gene transmembrane protein 35A Neighboring gene centromere protein I

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for m(5)U formation in both tRNA and rRNA. Laptev I, et al. RNA Biol, 2020 Apr. PMID 31736397, Free PMC Article
  2. Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Gendrel AV, et al. Mol Cell Biol, 2013 Aug. PMID 23754746, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for m(5)U formation in both tRNA and rRNA.
    Title: Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for m(5)U formation in both tRNA and rRNA.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (uridine-C5-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables rRNA (uridine-C5-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tRNA (uracil-5-)-methyltransferase homolog B
Names
TRM2 homolog
TRM2 homolog B
TRM2 tRNA methyltransferase 2 homolog B
rRNA (uracil-5-)-methyltransferase TRMT2B
tRNA (uracil(54)-C(5))-methyltransferase homolog
tRNA (uracil-5-)-methyltransferase homolog
NP_001161466.1
NP_001161467.1
NP_766128.2
XP_006528577.1
XP_011246036.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167994.1 → NP_001161466.1  tRNA (uracil-5-)-methyltransferase homolog B isoform a

    See identical proteins and their annotated locations for NP_001161466.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AK028999, AK046928, BC056937
    Consensus CDS
    CCDS41121.1
    UniProtKB/Swiss-Prot
    Q8BQJ6, Q8CE55
    UniProtKB/TrEMBL
    S4R2E5
    Related
    ENSMUSP00000108878.2, ENSMUST00000113252.8
    Conserved Domains (2) summary
    COG2265
    Location:83 → 486
    TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]
    cl17173
    Location:290 → 490
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. NM_001167995.1 → NP_001161467.1  tRNA (uracil-5-)-methyltransferase homolog B isoform b

    See identical proteins and their annotated locations for NP_001161467.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI835629, AK046928
    Consensus CDS
    CCDS53183.1
    UniProtKB/TrEMBL
    Q8C8J3
    Related
    ENSMUSP00000084819.4, ENSMUST00000087540.4

  3. NM_172540.2 → NP_766128.2  tRNA (uracil-5-)-methyltransferase homolog B isoform a

    See identical proteins and their annotated locations for NP_766128.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AK028999, AK046928, AK049523
    Consensus CDS
    CCDS41121.1
    UniProtKB/Swiss-Prot
    Q8BQJ6, Q8CE55
    UniProtKB/TrEMBL
    S4R2E5
    Related
    ENSMUSP00000084820.6, ENSMUST00000087541.12
    Conserved Domains (2) summary
    COG2265
    Location:83 → 486
    TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]
    cl17173
    Location:290 → 490
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    133123704..133177770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247734.4 → XP_011246036.1  tRNA (uracil-5-)-methyltransferase homolog B isoform X2

    UniProtKB/TrEMBL
    S4R2E5
    Related
    ENSMUSP00000138612.2, ENSMUST00000128115.8
    Conserved Domains (1) summary
    COG2265
    Location:83 → 418
    TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]

  2. XM_006528514.5 → XP_006528577.1  tRNA (uracil-5-)-methyltransferase homolog B isoform X1

    UniProtKB/TrEMBL
    S4R2E5
    Conserved Domains (1) summary
    COG2265
    Location:83 → 441
    TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BQJ6.1 GenPept UniProtKB/Swiss-Prot:Q8BQJ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous