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Slc43a2 solute carrier family 43, member 2 [ Mus musculus (house mouse) ]

Gene ID: 215113, updated on 11-Apr-2024

Summary

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Official Symbol
Slc43a2provided by MGI
Official Full Name
solute carrier family 43, member 2provided by MGI
Primary source
MGI:MGI:2442746
See related
Ensembl:ENSMUSG00000038178 AllianceGenome:MGI:2442746
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lat4; 7630402D21Rik
Summary
Enables L-amino acid transmembrane transporter activity. Acts upstream of or within L-amino acid transport. Located in plasma membrane. Is expressed in several structures, including adrenal medulla; metanephros; nephric duct of male; nervous system; and sensory organ. Orthologous to human SLC43A2 (solute carrier family 43 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 79.3), small intestine adult (RPKM 65.9) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Slc43a2 in Genome Data Viewer
Location:
11 B5; 11 45.92 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75420741..75468401)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75529915..75577575)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7017 Neighboring gene scavenger receptor class F, member 1 Neighboring gene Rab interacting lysosomal protein Neighboring gene STARR-positive B cell enhancer ABC_E9036 Neighboring gene STARR-positive B cell enhancer ABC_E10689 Neighboring gene STARR-seq mESC enhancer starr_29997 Neighboring gene predicted gene 45606 Neighboring gene microRNA 3971 Neighboring gene STARR-positive B cell enhancer ABC_E10690 Neighboring gene STARR-positive B cell enhancer ABC_E9366 Neighboring gene STARR-positive B cell enhancer ABC_E9827 Neighboring gene STARR-positive B cell enhancer ABC_E9367 Neighboring gene RIKEN cDNA 4931413K12 gene Neighboring gene predicted gene, 53686 Neighboring gene phosphatidylinositol transfer protein, alpha Neighboring gene cytochrome c oxidase, subunit VIIc pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phosphorylation of mouse intestinal basolateral amino acid uniporter LAT4 is controlled by food-entrained diurnal rhythm and dietary proteins. Oparija-Rogenmozere L, et al. PLoS One, 2020. PMID 32470053, Free PMC Article
  2. Essential amino acid transporter Lat4 (Slc43a2) is required for mouse development. Guetg A, et al. J Physiol, 2015 Mar 1. PMID 25480797, Free PMC Article
  3. Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function. Oparija L, et al. J Physiol, 2019 Jan. PMID 30379325, Free PMC Article
  4. Cancer SLC43A2 alters T cell methionine metabolism and histone methylation. Bian Y, et al. Nature, 2020 Sep. PMID 32879489, Free PMC Article
  5. Tissue-specific deletion of mouse basolateral uniporter LAT4 (Slc43a2) reveals its crucial role in small intestine and kidney amino acid transport. Rajendran A, et al. J Physiol, 2020 Nov. PMID 32841365, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cancer SLC43A2 alters T cell methionine metabolism and histone methylation.
    Title: Cancer SLC43A2 alters T cell methionine metabolism and histone methylation.
  2. Phosphorylation of mouse intestinal basolateral amino acid uniporter LAT4 is controlled by food-entrained diurnal rhythm and dietary proteins.
    Title: Phosphorylation of mouse intestinal basolateral amino acid uniporter LAT4 is controlled by food-entrained diurnal rhythm and dietary proteins.
  3. LAT4 is subject to a circadian regulation by phosphorylation in the mouse small intestine, and this novel regulatory mechanism is suggested to play an important role in the diurnal regulation of amino acid absorption.
    Title: Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function.
  4. Mice lacking Lat4 display a slight intrauterine growth restriction, postnatal malnutrition and early death.
    Title: Essential amino acid transporter Lat4 (Slc43a2) is required for mouse development.
  5. In situ hybridization experiments show that LAT4 mRNA is restricted to the epithelial cells of the distal tubule and the collecting duct in the kidney. In the intestine, LAT4 is mainly present in the cells of the crypt.
    Title: Identification of LAT4, a novel amino acid transporter with system L activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28931

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-isoleucine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-leucine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-leucine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-methionine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-phenylalanine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-phenylalanine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables neutral L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within L-alpha-amino acid transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within L-amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-leucine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-leucine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in isoleucine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in methionine transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of L-leucine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in neutral amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phenylalanine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phenylalanine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
large neutral amino acids transporter small subunit 4
Names
L-type amino L-acid transporter 4
L-type amino acid transporter 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199283.1 → NP_001186212.1  large neutral amino acids transporter small subunit 4

    See identical proteins and their annotated locations for NP_001186212.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AA017978, AK143773, AL591440, AL591496
    Consensus CDS
    CCDS25051.1
    UniProtKB/Swiss-Prot
    Q5CD76, Q8CGA3
    Related
    ENSMUSP00000126838.3, ENSMUST00000169547.9
    Conserved Domains (1) summary
    cd06174
    Location:90 → 239
    MFS; Major Facilitator Superfamily

  2. NM_001199284.1 → NP_001186213.1  large neutral amino acids transporter small subunit 4

    See identical proteins and their annotated locations for NP_001186213.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different segment from its 5' UTR, compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AA017978, AB120363, AK143773, AL591440, BY202700
    Consensus CDS
    CCDS25051.1
    UniProtKB/Swiss-Prot
    Q5CD76, Q8CGA3
    Related
    ENSMUSP00000104071.2, ENSMUST00000108433.8
    Conserved Domains (1) summary
    cd06174
    Location:90 → 239
    MFS; Major Facilitator Superfamily

  3. NM_173388.2 → NP_775564.1  large neutral amino acids transporter small subunit 4

    See identical proteins and their annotated locations for NP_775564.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains a different segment from its 5' UTR, compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AA017978, AK143773, AL591440, BY202700, CD550550
    Consensus CDS
    CCDS25051.1
    UniProtKB/Swiss-Prot
    Q5CD76, Q8CGA3
    Related
    ENSMUSP00000046074.8, ENSMUST00000042561.14
    Conserved Domains (1) summary
    cd06174
    Location:90 → 239
    MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    75420741..75468401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532825.4 → XP_006532888.1  large neutral amino acids transporter small subunit 4 isoform X1

    See identical proteins and their annotated locations for XP_006532888.1

    Conserved Domains (1) summary
    cd06174
    Location:90 → 239
    MFS; Major Facilitator Superfamily

  2. XM_030245780.2 → XP_030101640.1  large neutral amino acids transporter small subunit 4 isoform X2

    UniProtKB/Swiss-Prot
    Q5CD76, Q8CGA3
    Conserved Domains (1) summary
    cd06174
    Location:90 → 239
    MFS; Major Facilitator Superfamily

  3. XM_006532819.4 → XP_006532882.1  large neutral amino acids transporter small subunit 4 isoform X1

    See identical proteins and their annotated locations for XP_006532882.1

    Conserved Domains (1) summary
    cd06174
    Location:90 → 239
    MFS; Major Facilitator Superfamily

  4. XM_006532827.5 → XP_006532890.1  large neutral amino acids transporter small subunit 4 isoform X2

    See identical proteins and their annotated locations for XP_006532890.1

    UniProtKB/Swiss-Prot
    Q5CD76, Q8CGA3
    Conserved Domains (1) summary
    cd06174
    Location:90 → 239
    MFS; Major Facilitator Superfamily

  5. XM_036156511.1 → XP_036012404.1  large neutral amino acids transporter small subunit 4 isoform X2

    UniProtKB/Swiss-Prot
    Q5CD76, Q8CGA3
    Conserved Domains (1) summary
    cd06174
    Location:90 → 239
    MFS; Major Facilitator Superfamily

  6. XM_006532826.5 → XP_006532889.1  large neutral amino acids transporter small subunit 4 isoform X1

    See identical proteins and their annotated locations for XP_006532889.1

    Conserved Domains (1) summary
    cd06174
    Location:90 → 239
    MFS; Major Facilitator Superfamily

  7. XM_006532820.4 → XP_006532883.1  large neutral amino acids transporter small subunit 4 isoform X1

    See identical proteins and their annotated locations for XP_006532883.1

    Conserved Domains (1) summary
    cd06174
    Location:90 → 239
    MFS; Major Facilitator Superfamily

  8. XM_006532823.4 → XP_006532886.1  large neutral amino acids transporter small subunit 4 isoform X1

    See identical proteins and their annotated locations for XP_006532886.1

    Conserved Domains (1) summary
    cd06174
    Location:90 → 239
    MFS; Major Facilitator Superfamily

  9. XM_006532821.4 → XP_006532884.1  large neutral amino acids transporter small subunit 4 isoform X1

    See identical proteins and their annotated locations for XP_006532884.1

    Conserved Domains (1) summary
    cd06174
    Location:90 → 239
    MFS; Major Facilitator Superfamily

  10. XM_006532824.4 → XP_006532887.1  large neutral amino acids transporter small subunit 4 isoform X1

    See identical proteins and their annotated locations for XP_006532887.1

    Conserved Domains (1) summary
    cd06174
    Location:90 → 239
    MFS; Major Facilitator Superfamily

  11. XM_006532822.5 → XP_006532885.1  large neutral amino acids transporter small subunit 4 isoform X1

    See identical proteins and their annotated locations for XP_006532885.1

    Conserved Domains (1) summary
    cd06174
    Location:90 → 239
    MFS; Major Facilitator Superfamily

  12. XM_036156512.1 → XP_036012405.1  large neutral amino acids transporter small subunit 4 isoform X3

RNA

  1. XR_003949380.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CGA3.1 GenPept UniProtKB/Swiss-Prot:Q8CGA3

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