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Maneal mannosidase, endo-alpha-like [ Mus musculus (house mouse) ]

Gene ID: 215090, updated on 11-Apr-2024

Summary

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Official Symbol
Manealprovided by MGI
Official Full Name
mannosidase, endo-alpha-likeprovided by MGI
Primary source
MGI:MGI:2684896
See related
Ensembl:ENSMUSG00000042763 AllianceGenome:MGI:2684896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm50
Summary
Predicted to enable alpha-mannosidase activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Orthologous to human MANEAL (mannosidase endo-alpha like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 15.7), CNS E18 (RPKM 15.1) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 57.92 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124749032..124774731, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (124855239..124880938, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene metal response element binding transcription factor 1 Neighboring gene RIKEN cDNA 1110065P20 gene Neighboring gene predicted gene, 54256 Neighboring gene yrdC domain containing (E.coli) Neighboring gene RIKEN cDNA 1700125G02 gene Neighboring gene Eph receptor A10 Neighboring gene cell division cycle associated 8 Neighboring gene STARR-positive B cell enhancer ABC_E424

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Homology

Clone Names

  • MGC86147

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glycoprotein endo-alpha-1,2-mannosidase-like protein
NP_001007574.1
XP_030109255.1
XP_030109256.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007573.3 → NP_001007574.1  glycoprotein endo-alpha-1,2-mannosidase-like protein

    See identical proteins and their annotated locations for NP_001007574.1

    Status: VALIDATED

    Source sequence(s)
    AL606933
    Consensus CDS
    CCDS18629.1
    UniProtKB/Swiss-Prot
    Q3UVP2, Q6P1J0
    Related
    ENSMUSP00000066000.8, ENSMUST00000064444.8
    Conserved Domains (1) summary
    cd11574
    Location:100 → 441
    GH99; Glycoside hydrolase family 99, an endo-alpha-1,2-mannosidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    124749032..124774731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253396.1 → XP_030109256.1  glycoprotein endo-alpha-1,2-mannosidase-like protein isoform X2

    Conserved Domains (1) summary
    cd11574
    Location:24 → 224
    GH99; Glycoside hydrolase family 99, an endo-alpha-1,2-mannosidase

  2. XM_030253395.2 → XP_030109255.1  glycoprotein endo-alpha-1,2-mannosidase-like protein isoform X1

    Conserved Domains (1) summary
    cl01529
    Location:100 → 215
    GH99_GH71_like; Glycoside hydrolase families 71, 99, and related domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P1J0.1 GenPept UniProtKB/Swiss-Prot:Q6P1J0

Gene LinkOut

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