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Fam20b FAM20B, glycosaminoglycan xylosylkinase [ Mus musculus (house mouse) ]

Gene ID: 215015, updated on 28-Apr-2024

Summary

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Official Symbol
Fam20bprovided by MGI
Official Full Name
FAM20B, glycosaminoglycan xylosylkinaseprovided by MGI
Primary source
MGI:MGI:2443990
See related
Ensembl:ENSMUSG00000033557 AllianceGenome:MGI:2443990
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0475; C530043G21Rik
Summary
Predicted to enable phosphotransferase activity, alcohol group as acceptor. Predicted to be involved in proteoglycan biosynthetic process. Predicted to act upstream of or within phosphorylation. Located in Golgi apparatus. Is expressed in articular cartilage; lower jaw; lower jaw incisor; and lower jaw molar. Orthologous to human FAM20B (FAM20B glycosaminoglycan xylosylkinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 20.4), kidney adult (RPKM 16.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 G3; 1 67.71 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (156506127..156547204, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (156678562..156719095, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02742 Neighboring gene ABL proto-oncogene 2, non-receptor tyrosine kinase Neighboring gene STARR-positive B cell enhancer ABC_E10049 Neighboring gene STARR-positive B cell enhancer ABC_E4362 Neighboring gene STARR-seq mESC enhancer starr_02753 Neighboring gene STARR-positive B cell enhancer ABC_E4363 Neighboring gene torsin family 3, member A Neighboring gene STARR-seq mESC enhancer starr_02755 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:158640993-158641176 Neighboring gene STARR-positive B cell enhancer mm9_chr1:158682524-158682825 Neighboring gene predicted gene, 39683 Neighboring gene PCNA-associated factor pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deficiency of Fam20b-Catalyzed Glycosaminoglycan Chain Synthesis in Neural Crest Leads to Cleft Palate. Chen X, et al. Int J Mol Sci, 2023 Jun 1. PMID 37298583, Free PMC Article
  2. Inactivation of FAM20B causes cell fate changes in annulus fibrosus of mouse intervertebral disc and disc defects via the alterations of TGF-β and MAPK signaling pathways. Saiyin W, et al. Biochim Biophys Acta Mol Basis Dis, 2019 Dec 1. PMID 31513834, Free PMC Article
  3. Inactivation of Fam20b in the neural crest-derived mesenchyme of mouse causes multiple craniofacial defects. Liu X, et al. Eur J Oral Sci, 2018 Oct. PMID 30105814, Free PMC Article
  4. Inactivation of Fam20B in the dental epithelium of mice leads to supernumerary incisors. Tian Y, et al. Eur J Oral Sci, 2015 Dec. PMID 26465965, Free PMC Article
  5. Inactivation of Fam20B in Joint Cartilage Leads to Chondrosarcoma and Postnatal Ossification Defects. Ma P, et al. Sci Rep, 2016 Jul 13. PMID 27405802, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deficiency of Fam20b-Catalyzed Glycosaminoglycan Chain Synthesis in Neural Crest Leads to Cleft Palate.
    Title: Deficiency of Fam20b-Catalyzed Glycosaminoglycan Chain Synthesis in Neural Crest Leads to Cleft Palate.
  2. FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling.
    Title: FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling.
  3. These results indicate that FAM20B plays an essential role in the development of annulus fibrosus by regulating the TGF-beta signaling and MAPK signaling pathways.
    Title: Inactivation of FAM20B causes cell fate changes in annulus fibrosus of mouse intervertebral disc and disc defects via the alterations of TGF-β and MAPK signaling pathways.
  4. FAM20B-catalyzed proteoglycans regulate postnatal endochondral ossification partially through the mediation of WNT signaling.
    Title: Inactivation of Fam20B in Joint Cartilage Leads to Chondrosarcoma and Postnatal Ossification Defects.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphotransferase activity, alcohol group as acceptor ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glycosaminoglycan xylosylkinase
Names
family with sequence similarity 20, member B
xylose kinase
NP_001404962.1
NP_001404963.1
NP_001404964.1
NP_001404965.1
NP_001404966.1
NP_001404968.1
NP_663388.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418033.1 → NP_001404962.1  glycosaminoglycan xylosylkinase isoform a

    Status: VALIDATED

    Source sequence(s)
    AC145078
    UniProtKB/Swiss-Prot
    Q3V201, Q6ZQA3, Q8BWX2, Q8VCS3

  2. NM_001418034.1 → NP_001404963.1  glycosaminoglycan xylosylkinase isoform a

    Status: VALIDATED

    Source sequence(s)
    AC145078
    UniProtKB/Swiss-Prot
    Q3V201, Q6ZQA3, Q8BWX2, Q8VCS3
    Related
    ENSMUSP00000112534.2, ENSMUST00000122424.8

  3. NM_001418035.1 → NP_001404964.1  glycosaminoglycan xylosylkinase isoform a

    Status: VALIDATED

    Source sequence(s)
    AC145078
    UniProtKB/Swiss-Prot
    Q3V201, Q6ZQA3, Q8BWX2, Q8VCS3

  4. NM_001418036.1 → NP_001404965.1  glycosaminoglycan xylosylkinase isoform b

    Status: VALIDATED

    Source sequence(s)
    AC145078

  5. NM_001418037.1 → NP_001404966.1  glycosaminoglycan xylosylkinase isoform b

    Status: VALIDATED

    Source sequence(s)
    AC145078

  6. NM_001418039.1 → NP_001404968.1  glycosaminoglycan xylosylkinase isoform c

    Status: VALIDATED

    Source sequence(s)
    AC145078

  7. NM_145413.5 → NP_663388.1  glycosaminoglycan xylosylkinase isoform a

    See identical proteins and their annotated locations for NP_663388.1

    Status: VALIDATED

    Source sequence(s)
    AC145078
    Consensus CDS
    CCDS15395.1
    UniProtKB/Swiss-Prot
    Q3V201, Q6ZQA3, Q8BWX2, Q8VCS3
    Related
    ENSMUSP00000083322.7, ENSMUST00000086153.8
    Conserved Domains (1) summary
    cd10470
    Location:188 → 394
    FAM20B_C; C-terminal putative kinase domain of FAM20B xylose kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    156506127..156547204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCS3.1 GenPept UniProtKB/Swiss-Prot:Q8VCS3

Gene LinkOut

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