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Vezt vezatin, adherens junctions transmembrane protein [ Mus musculus (house mouse) ]

Gene ID: 215008, updated on 11-Apr-2024

Summary

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Official Symbol
Veztprovided by MGI
Official Full Name
vezatin, adherens junctions transmembrane proteinprovided by MGI
Primary source
MGI:MGI:2143698
See related
Ensembl:ENSMUSG00000036099 AllianceGenome:MGI:2143698
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A630071D13Rik
Summary
This gene encodes a transmembrane protein that is essential for the formation of adherens junctions. It is required for both the pre-implantation morphogenesis of a blastocyst and for the implantation process. The encoded protein is also a component of the ankle-link complex in cochlear hair cells, where it may effect resilience to sound trauma. It is also thought to be involved in dendritic spine morphogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Expression
Ubiquitous expression in CNS E18 (RPKM 7.8), whole brain E14.5 (RPKM 7.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10; 10 C2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93797384..93871661, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93961522..94035799, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27591 Neighboring gene STARR-positive B cell enhancer mm9_chr10:93281373-93281673 Neighboring gene STARR-seq mESC enhancer starr_27592 Neighboring gene predicted gene, 26239 Neighboring gene STARR-seq mESC enhancer starr_27593 Neighboring gene ubiquitin specific peptidase 44 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93352494-93352603 Neighboring gene methionine aminopeptidase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93401444-93401825 Neighboring gene STARR-seq mESC enhancer starr_27594 Neighboring gene microRNA 331 Neighboring gene STARR-positive B cell enhancer ABC_E1811 Neighboring gene mitochondrial inner membrane protease subunit 1 pseudogene Neighboring gene FYVE, RhoGEF and PH domain containing 6 Neighboring gene B-cell CLL/lymphoma 9-like pseudogene Neighboring gene nuclear receptor subfamily 2, group C, member 1 Neighboring gene predicted gene, 26122

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Vezatin is essential for dendritic spine morphogenesis and functional synaptic maturation. Danglot L, et al. J Neurosci, 2012 Jun 27. PMID 22745500, Free PMC Article
  2. Vezatin, a potential target for ADP-ribosylation factor 6, regulates the dendritic formation of hippocampal neurons. Sanda M, et al. Neurosci Res, 2010 Jun. PMID 20188128
  3. Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cells. Bahloul A, et al. EMBO Mol Med, 2009 May. PMID 20049712, Free PMC Article
  4. Vezatin, a ubiquitous protein of adherens cell-cell junctions, is exclusively expressed in germ cells in mouse testis. Hyenne V, et al. Reproduction, 2007 Mar. PMID 17379651
  5. Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity. Wang Y, et al. Cell Death Dis, 2021 Oct 12. PMID 34642320, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity.
    Title: Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity.
  2. These results suggest a role of Vezatin in dendritic spine morphogenesis and functional synaptic maturation.
    Title: Vezatin is essential for dendritic spine morphogenesis and functional synaptic maturation.
  3. present study suggests that vezatin may regulate dendritic formation as a downstream effector of ARF6.
    Title: Vezatin, a potential target for ADP-ribosylation factor 6, regulates the dendritic formation of hippocampal neurons.
  4. vezatin associates with actin filaments at cell-cell junctions.
    Title: Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cells.
  5. These in vitro observations reinforce the idea that homozygous vezatin-null mutants die at the time of implantation because of a defect in intercellular adhesion.
    Title: Conditional knock-out reveals that zygotic vezatin-null mouse embryos die at implantation.
  6. Required for morphogenesis of the preimplantation mouse embryo.
    Title: Vezatin, a protein associated to adherens junctions, is required for mouse blastocyst morphogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 6330418D12

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables myosin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chordate embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in synapse maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synapse maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
part_of stereocilia ankle link complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
vezatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304572.1 → NP_001291501.1  vezatin isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC122901, AK031192, AK042209, AW124866, BC056428, BQ555053
    Consensus CDS
    CCDS78886.1
    UniProtKB/Swiss-Prot
    Q3ZK22
    Related
    ENSMUSP00000113983.2, ENSMUST00000118077.8
    Conserved Domains (1) summary
    pfam12632
    Location:150 → 438
    Vezatin; Mysoin-binding motif of peroxisomes

  2. NM_001304575.1 → NP_001291504.1  vezatin isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the central coding region, compared to variant 1. It encodes isoform 3, which is longer and has a distinct internal segment, compared to isoform 1.
    Source sequence(s)
    AC122901, AK031192, AK031848, AK036017, AK042209, AW124866, BC056428
    Consensus CDS
    CCDS78887.1
    UniProtKB/TrEMBL
    D3Z4E6
    Related
    ENSMUSP00000113715.2, ENSMUST00000119818.8
    Conserved Domains (2) summary
    pfam10243
    Location:463 → 772
    MIP-T3; Microtubule-binding protein MIP-T3
    pfam12632
    Location:150 → 442
    Vezatin; Mysoin-binding motif of peroxisomes

  3. NM_001304720.1 → NP_001291649.1  vezatin isoform 4

    See identical proteins and their annotated locations for NP_001291649.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 3' terminal exon compared to variant 1. It encodes isoform 4, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC122901, AK031192, AK042209, AK042540, AW124866, BQ555053, CF730355
    Consensus CDS
    CCDS83750.1
    UniProtKB/Swiss-Prot
    Q3ZK22
    Related
    ENSMUSP00000113321.2, ENSMUST00000118205.8
    Conserved Domains (1) summary
    pfam12632
    Location:150 → 438
    Vezatin; Mysoin-binding motif of peroxisomes

  4. NM_172538.5 → NP_766126.2  vezatin isoform 1

    See identical proteins and their annotated locations for NP_766126.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC122901, AK031192, AK031848, AK036017, AK042209, AK048068, AW124866, BC056428
    Consensus CDS
    CCDS36038.1
    UniProtKB/Swiss-Prot
    A0M8X3, Q3ZK21, Q3ZK22, Q8BY12, Q8BYB4, Q8BZB5
    Related
    ENSMUSP00000037955.7, ENSMUST00000047711.13
    Conserved Domains (2) summary
    pfam10243
    Location:459 → 768
    MIP-T3; Microtubule-binding protein MIP-T3
    pfam12632
    Location:150 → 438
    Vezatin; Mysoin-binding motif of peroxisomes

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    93797384..93871661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3ZK22.2 GenPept UniProtKB/Swiss-Prot:Q3ZK22

Gene LinkOut

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