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Mob3b MOB kinase activator 3B [ Mus musculus (house mouse) ]

Gene ID: 214944, updated on 5-Mar-2024

Summary

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Official Symbol
Mob3bprovided by MGI
Official Full Name
MOB kinase activator 3Bprovided by MGI
Primary source
MGI:MGI:2664539
See related
Ensembl:ENSMUSG00000073910 AllianceGenome:MGI:2664539
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mobkl2b; 8430436F23Rik; A430018A01Rik
Summary
Predicted to enable protein kinase activator activity. Predicted to be involved in positive regulation of protein phosphorylation; regulation of hippo signaling; and signal transduction. Predicted to be active in cytoplasm and nucleus. Is expressed in lower jaw incisor; lower jaw molar; upper jaw incisor; and upper jaw molar. Orthologous to human MOB3B (MOB kinase activator 3B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 2.5), liver adult (RPKM 2.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mob3b in Genome Data Viewer
Location:
4 A5; 4 16.86 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (34949074..35157490, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (34949074..35157524, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ubiquitin protein ligase E3 component n-recognin 7 (putative) pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr4:34905638-34905939 Neighboring gene predicted gene 12362 Neighboring gene STARR-seq mESC enhancer starr_09933 Neighboring gene STARR-seq mESC enhancer starr_09934 Neighboring gene predicted gene, 33620 Neighboring gene predicted gene, 52727 Neighboring gene STARR-positive B cell enhancer ABC_E9236 Neighboring gene STARR-positive B cell enhancer mm9_chr4:35078889-35079190 Neighboring gene STARR-seq mESC enhancer starr_09939 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:35103331-35103583 Neighboring gene interferon kappa Neighboring gene C9orf72, member of C9orf72-SMCR8 complex Neighboring gene ribosomal protein S2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:35173352-35173535 Neighboring gene uncharacterized LOC118568669

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of a novel murine type I IFN in the pancreatic islets induces diabetes in mice. Vassileva G, et al. J Immunol, 2003 Jun 1. PMID 12759458
  2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28259

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MOB kinase activator 3B
Names
MOB1 (Mps One Binder) kinase activator-like 2B
mob1 homolog 2b
mps one binder kinase activator-like 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178061.5 → NP_835162.1  MOB kinase activator 3B

    See identical proteins and their annotated locations for NP_835162.1

    Status: VALIDATED

    Source sequence(s)
    AK039841, AK087285, AL929565
    Consensus CDS
    CCDS18036.1
    UniProtKB/Swiss-Prot
    Q3U2L2, Q8BU65, Q8VE04
    UniProtKB/TrEMBL
    Q3TC05
    Related
    ENSMUSP00000100040.4, ENSMUST00000102975.10
    Conserved Domains (1) summary
    pfam03637
    Location:35 → 207
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    34949074..35157490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253394.2 → XP_030109254.1  MOB kinase activator 3B isoform X1

    UniProtKB/Swiss-Prot
    Q3U2L2, Q8BU65, Q8VE04
    UniProtKB/TrEMBL
    Q3TC05
    Conserved Domains (1) summary
    pfam03637
    Location:35 → 207
    Mob1_phocein; Mob1/phocein family

  2. XM_006537753.4 → XP_006537816.1  MOB kinase activator 3B isoform X1

    See identical proteins and their annotated locations for XP_006537816.1

    UniProtKB/Swiss-Prot
    Q3U2L2, Q8BU65, Q8VE04
    UniProtKB/TrEMBL
    Q3TC05
    Conserved Domains (1) summary
    pfam03637
    Location:35 → 207
    Mob1_phocein; Mob1/phocein family

  3. XM_036163953.1 → XP_036019846.1  MOB kinase activator 3B isoform X1

    UniProtKB/Swiss-Prot
    Q3U2L2, Q8BU65, Q8VE04
    UniProtKB/TrEMBL
    Q3TC05
    Conserved Domains (1) summary
    pfam03637
    Location:35 → 207
    Mob1_phocein; Mob1/phocein family

  4. XM_006537752.5 → XP_006537815.1  MOB kinase activator 3B isoform X1

    See identical proteins and their annotated locations for XP_006537815.1

    UniProtKB/Swiss-Prot
    Q3U2L2, Q8BU65, Q8VE04
    UniProtKB/TrEMBL
    Q3TC05
    Conserved Domains (1) summary
    pfam03637
    Location:35 → 207
    Mob1_phocein; Mob1/phocein family

  5. XM_006537755.5 → XP_006537818.1  MOB kinase activator 3B isoform X2

    UniProtKB/TrEMBL
    Q3TC05
    Conserved Domains (1) summary
    pfam03637
    Location:35 → 207
    Mob1_phocein; Mob1/phocein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VE04.1 GenPept UniProtKB/Swiss-Prot:Q8VE04

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