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Antkmt adenine nucleotide translocase lysine methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 214917, updated on 11-Apr-2024

Summary

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Official Symbol
Antkmtprovided by MGI
Official Full Name
adenine nucleotide translocase lysine methyltransferaseprovided by MGI
Primary source
MGI:MGI:2384888
See related
Ensembl:ENSMUSG00000057411 AllianceGenome:MGI:2384888
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ANT-KMT; Fam173a
Summary
Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine trimethylation; positive regulation of proton-transporting ATP synthase activity, rotational mechanism; and regulation of mitochondrial ATP synthesis coupled proton transport. Predicted to act upstream of or within methylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including adipose tissue; alimentary system; immune system; nervous system; and reproductive system. Orthologous to human ANTKMT (adenine nucleotide translocase lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 50.0), colon adult (RPKM 46.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 12.89 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26009474..26011761, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25790500..25792787, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41550 Neighboring gene STARR-positive B cell enhancer ABC_E3191 Neighboring gene cytosolic iron-sulfur assembly component 3 Neighboring gene microRNA 6966 Neighboring gene hydroxyacylglutathione hydrolase-like Neighboring gene STARR-positive B cell enhancer ABC_E5579 Neighboring gene coiled-coil domain containing 78 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:25929287-25929470 Neighboring gene meteorin, glial cell differentiation regulator Neighboring gene F-box and leucine-rich repeat protein 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC6974

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-lysine trimethylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-lysine trimethylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitochondrial ATP synthesis coupled proton transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adenine nucleotide translocase lysine N-methyltransferase
Names
family with sequence similarity 173, member A
protein FAM173A
protein N-lysine methyltransferase FAM173A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285982.1 → NP_001272911.1  adenine nucleotide translocase lysine N-methyltransferase isoform 2

    See identical proteins and their annotated locations for NP_001272911.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC134908
    Consensus CDS
    CCDS89025.1
    UniProtKB/TrEMBL
    Q91VW0
    Related
    ENSMUSP00000158301.2, ENSMUST00000236683.2

  2. NM_001357989.1 → NP_001344918.1  adenine nucleotide translocase lysine N-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134908, AI850632
    Consensus CDS
    CCDS89025.1
    UniProtKB/TrEMBL
    Q91VW0

  3. NM_145410.4 → NP_663385.2  adenine nucleotide translocase lysine N-methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_663385.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC134908, AK162337, BB855744
    Consensus CDS
    CCDS28528.1
    UniProtKB/Swiss-Prot
    Q501J2
    Related
    ENSMUSP00000072518.8, ENSMUST00000072735.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    26009474..26011761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q501J2.1 GenPept UniProtKB/Swiss-Prot:Q501J2

Gene LinkOut

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