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Csnk1g1 casein kinase 1, gamma 1 [ Mus musculus (house mouse) ]

Gene ID: 214897, updated on 21-Apr-2024

Summary

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Official Symbol
Csnk1g1provided by MGI
Official Full Name
casein kinase 1, gamma 1provided by MGI
Primary source
MGI:MGI:2660884
See related
Ensembl:ENSMUSG00000032384 AllianceGenome:MGI:2660884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9130020E21Rik
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway; and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in central nervous system; genitourinary system; retina; and skin. Orthologous to human CSNK1G1 (casein kinase 1 gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 3.9), whole brain E14.5 (RPKM 3.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 C; 9 35.6 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65816235..65952297)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65908968..66045015)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene predicted gene, 53535 Neighboring gene STARR-positive B cell enhancer ABC_E6756 Neighboring gene STARR-seq mESC enhancer starr_24473 Neighboring gene PCNA clamp associated factor Neighboring gene predicted gene, 23248 Neighboring gene predicted gene, 22657 Neighboring gene STARR-positive B cell enhancer mm9_chr9:65852147-65852448 Neighboring gene STARR-positive B cell enhancer ABC_E6757 Neighboring gene STARR-positive B cell enhancer ABC_E11412 Neighboring gene peptidylprolyl isomerase B Neighboring gene sorting nexin 22 Neighboring gene STARR-seq mESC enhancer starr_24475 Neighboring gene STARR-positive B cell enhancer ABC_E5080 Neighboring gene sorting nexin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nucleotide sequence of a cDNA encoding an alternative form of LEF-1. Fujimoto S, et al. Nucleic Acids Res, 1993 Sep 11. PMID 8415007, Free PMC Article
  2. Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3. Lee SY, et al. Cell Death Dis, 2019 Dec 4. PMID 31801942, Free PMC Article
  3. Physiological role for casein kinase 1 in glutamatergic synaptic transmission. Chergui K, et al. J Neurosci, 2005 Jul 13. PMID 16014721, Free PMC Article
  4. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
casein kinase I isoform gamma-1; casein kinase I
Names
CKI-gamma 1
casein kinase I, gamma 1
NP_775277.2
XP_006511071.1
XP_011241005.1
XP_011241006.1
XP_011241007.1
XP_011241008.1
XP_011241009.1
XP_011241010.1
XP_011241011.1
XP_011241012.1
XP_011241014.1
XP_030100085.1
XP_030100087.1
XP_036010717.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173185.2 → NP_775277.2  casein kinase I isoform gamma-1

    See identical proteins and their annotated locations for NP_775277.2

    Status: VALIDATED

    Source sequence(s)
    AC112676, AK090262, BC064645
    Consensus CDS
    CCDS23300.1
    UniProtKB/Swiss-Prot
    E9QPK6, Q8BTH8
    UniProtKB/TrEMBL
    A0A0U1RP94
    Related
    ENSMUSP00000034949.4, ENSMUST00000034949.10
    Conserved Domains (2) summary
    cd14126
    Location:43 → 331
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:331 → 418
    CK1gamma_C; Casein kinase 1 gamma C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    65816235..65952297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511008.4 → XP_006511071.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_006511071.1

    UniProtKB/TrEMBL
    A0A0U1RP94
    Conserved Domains (2) summary
    cd14126
    Location:43 → 331
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:331 → 429
    CK1gamma_C; Casein kinase 1 gamma C terminal

  2. XM_030244227.2 → XP_030100087.1  casein kinase I isoform X2

    UniProtKB/Swiss-Prot
    E9QPK6, Q8BTH8
    UniProtKB/TrEMBL
    A0A0U1RP94
    Related
    ENSMUSP00000145947.2, ENSMUST00000206594.2
    Conserved Domains (2) summary
    cd14126
    Location:43 → 331
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:331 → 418
    CK1gamma_C; Casein kinase 1 gamma C terminal

  3. XM_011242704.2 → XP_011241006.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011241006.1

    UniProtKB/TrEMBL
    A0A0U1RP94
    Conserved Domains (2) summary
    cd14126
    Location:43 → 331
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:331 → 429
    CK1gamma_C; Casein kinase 1 gamma C terminal

  4. XM_011242703.2 → XP_011241005.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011241005.1

    UniProtKB/TrEMBL
    A0A0U1RP94
    Conserved Domains (2) summary
    cd14126
    Location:43 → 331
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:331 → 429
    CK1gamma_C; Casein kinase 1 gamma C terminal

  5. XM_011242709.3 → XP_011241011.1  casein kinase I isoform X3

    See identical proteins and their annotated locations for XP_011241011.1

    UniProtKB/TrEMBL
    A0A0U1RPM8, Q6P2B2
    Related
    ENSMUSP00000113160.2, ENSMUST00000117849.3
    Conserved Domains (2) summary
    cd14126
    Location:43 → 331
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:331 → 381
    CK1gamma_C; Casein kinase 1 gamma C terminal

  6. XM_011242710.2 → XP_011241012.1  casein kinase I isoform X4

    UniProtKB/TrEMBL
    A0A0U1RNW0, A0A0U1RPM8
    Related
    ENSMUSP00000145724.2, ENSMUST00000205379.2
    Conserved Domains (2) summary
    cd14126
    Location:43 → 331
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:331 → 381
    CK1gamma_C; Casein kinase 1 gamma C terminal

  7. XM_011242707.2 → XP_011241009.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011241009.1

    UniProtKB/TrEMBL
    A0A0U1RP94
    Conserved Domains (2) summary
    cd14126
    Location:43 → 331
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:331 → 429
    CK1gamma_C; Casein kinase 1 gamma C terminal

  8. XM_011242706.2 → XP_011241008.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011241008.1

    UniProtKB/TrEMBL
    A0A0U1RP94
    Conserved Domains (2) summary
    cd14126
    Location:43 → 331
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:331 → 429
    CK1gamma_C; Casein kinase 1 gamma C terminal

  9. XM_011242705.2 → XP_011241007.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011241007.1

    UniProtKB/TrEMBL
    A0A0U1RP94
    Conserved Domains (2) summary
    cd14126
    Location:43 → 331
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:331 → 429
    CK1gamma_C; Casein kinase 1 gamma C terminal

  10. XM_011242712.3 → XP_011241014.1  casein kinase I isoform X5

    UniProtKB/TrEMBL
    A0A0U1RPD7, A0A0U1RPM8
    Related
    ENSMUSP00000145938.2, ENSMUST00000130798.3
    Conserved Domains (2) summary
    cd14126
    Location:43 → 331
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:331 → 388
    CK1gamma_C; Casein kinase 1 gamma C terminal

  11. XM_011242708.3 → XP_011241010.1  casein kinase I isoform X2

    See identical proteins and their annotated locations for XP_011241010.1

    UniProtKB/Swiss-Prot
    E9QPK6, Q8BTH8
    UniProtKB/TrEMBL
    A0A0U1RP94
    Conserved Domains (2) summary
    cd14126
    Location:43 → 331
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:331 → 418
    CK1gamma_C; Casein kinase 1 gamma C terminal

  12. XM_030244225.2 → XP_030100085.1  casein kinase I isoform X1

    UniProtKB/TrEMBL
    A0A0U1RP94
    Conserved Domains (2) summary
    cd14126
    Location:43 → 331
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:331 → 429
    CK1gamma_C; Casein kinase 1 gamma C terminal

  13. XM_036154824.1 → XP_036010717.1  casein kinase I isoform X1

    UniProtKB/TrEMBL
    A0A0U1RP94
    Conserved Domains (2) summary
    cd14126
    Location:43 → 331
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:331 → 429
    CK1gamma_C; Casein kinase 1 gamma C terminal

RNA

  1. XR_003947839.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BTH8.2 GenPept UniProtKB/Swiss-Prot:Q8BTH8

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