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Neurl3 neuralized E3 ubiquitin protein ligase 3 [ Mus musculus (house mouse) ]

Gene ID: 214854, updated on 2-Apr-2024

Summary

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Official Symbol
Neurl3provided by MGI
Official Full Name
neuralized E3 ubiquitin protein ligase 3provided by MGI
Primary source
MGI:MGI:2429944
See related
Ensembl:ENSMUSG00000047180 AllianceGenome:MGI:2429944
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lincr; 2010300P06Rik
Summary
Enables ubiquitin protein ligase activity. Acts upstream of or within protein ubiquitination. Is expressed in lung epithelium; metanephros; nervous system; and renal vasculature. Orthologous to human NEURL3 (neuralized E3 ubiquitin protein ligase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 50.5), small intestine adult (RPKM 43.9) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 B; 1 15.18 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (36303683..36313755, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (36264602..36274674, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene UDP-glucose glycoprotein glucosyltransferase 1 Neighboring gene elongation factor RNA polymerase II 2 pseudogene Neighboring gene predicted gene, 39625 Neighboring gene STARR-positive B cell enhancer ABC_E4308 Neighboring gene STARR-positive B cell enhancer ABC_E3268 Neighboring gene STARR-positive B cell enhancer ABC_E2541 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:36364755-36365011 Neighboring gene AT-rich interaction domain 5A Neighboring gene KAT8 regulatory NSL complex subunit 3 Neighboring gene microRNA 6898

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpression of LINCR in the developing mouse lung epithelium inhibits distal differentiation and induces cystic changes. Londhe VA, et al. Dev Dyn, 2015 Jul. PMID 25904058
  2. Glucocorticoid-attenuated response genes induced in the lung during endotoxemia. Smith JB, et al. Am J Physiol Lung Cell Mol Physiol, 2002 Sep. PMID 12169584
  3. A novel inflammation-induced ubiquitin E3 ligase in alveolar type II cells. Hu Y, et al. Biochem Biophys Res Commun, 2005 Jul 22. PMID 15936721
  4. Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals. Hou S, et al. Cell Res, 2022 Apr. PMID 35079138, Free PMC Article
  5. E3 ubiquitin ligase NEURL3 promotes innate antiviral response through catalyzing K63-linked ubiquitination of IRF7. Qi F, et al. FASEB J, 2022 Aug. PMID 35792897

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Divergent expression of Neurl3 from hemogenic endothelial cells to hematopoietic stem progenitor cells during development.
    Title: Divergent expression of Neurl3 from hemogenic endothelial cells to hematopoietic stem progenitor cells during development.
  2. E3 ubiquitin ligase NEURL3 promotes innate antiviral response through catalyzing K63-linked ubiquitination of IRF7.
    Title: E3 ubiquitin ligase NEURL3 promotes innate antiviral response through catalyzing K63-linked ubiquitination of IRF7.
  3. LINCR may exert its effects on distal lung development in this model through activation of the Notch signaling pathway.
    Title: Overexpression of LINCR in the developing mouse lung epithelium inhibits distal differentiation and induces cystic changes.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein ubiquitination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ubiquitin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase NEURL3
Names
E3 ubiquitin-protein ligase LINCR
RING-type E3 ubiquitin transferase NEURL3
lung inducible neuralized-related C3HC4 RING finger
lung-inducible neuralized-related C3CH4 RING domain protein
lung-inducible neuralized-related C3CH4 RING domain-containing protein
lung-inducible neuralized-related C3HC4 RING domain protein
neuralized homolog 3 homolog
neuralized-like protein 3
NP_700457.1
XP_006495909.1
XP_006495910.1
XP_006495911.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153408.2 → NP_700457.1  E3 ubiquitin-protein ligase NEURL3

    See identical proteins and their annotated locations for NP_700457.1

    Status: PROVISIONAL

    Source sequence(s)
    AC132456, AC133102
    Consensus CDS
    CCDS14875.1
    UniProtKB/Swiss-Prot
    Q8BS05, Q8CJC5
    Related
    ENSMUSP00000055437.7, ENSMUST00000056946.8
    Conserved Domains (2) summary
    cd16552
    Location:195 → 236
    RING-HC_NEURL3; RING finger, HC subclass, found in neuralized-like protein 3 (NEURL3) and similar proteins
    pfam07177
    Location:20 → 173
    Neuralized

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    36303683..36313755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495848.4 → XP_006495911.1  E3 ubiquitin-protein ligase NEURL3 isoform X2

    See identical proteins and their annotated locations for XP_006495911.1

    UniProtKB/Swiss-Prot
    Q8BS05, Q8CJC5
    Conserved Domains (2) summary
    cd16552
    Location:195 → 236
    RING-HC_NEURL3; RING finger, HC subclass, found in neuralized-like protein 3 (NEURL3) and similar proteins
    pfam07177
    Location:20 → 173
    Neuralized

  2. XM_006495847.1 → XP_006495910.1  E3 ubiquitin-protein ligase NEURL3 isoform X1

    See identical proteins and their annotated locations for XP_006495910.1

    Conserved Domains (2) summary
    cd16552
    Location:209 → 250
    RING-HC_NEURL3; RING finger, HC subclass, found in neuralized-like protein 3 (NEURL3) and similar proteins
    pfam07177
    Location:34 → 187
    Neuralized

  3. XM_006495846.4 → XP_006495909.1  E3 ubiquitin-protein ligase NEURL3 isoform X1

    See identical proteins and their annotated locations for XP_006495909.1

    Conserved Domains (2) summary
    cd16552
    Location:209 → 250
    RING-HC_NEURL3; RING finger, HC subclass, found in neuralized-like protein 3 (NEURL3) and similar proteins
    pfam07177
    Location:34 → 187
    Neuralized
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CJC5.1 GenPept UniProtKB/Swiss-Prot:Q8CJC5

Gene LinkOut

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