Zfp609 zinc finger protein 609 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp609provided by MGI
Official Full Name: zinc finger protein 609provided by MGI
Primary source: MGI:MGI:2674092
See related: Ensembl:ENSMUSG00000040524 AllianceGenome:MGI:2674092
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Znf609; mKIAA0295; 9830165N24
Summary: Enables promoter-specific chromatin binding activity. Involved in positive regulation of neuron migration; positive regulation of transcription by RNA polymerase II; and regulation of myoblast proliferation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brown fat; early conceptus; genitourinary system; gut; and nervous system. Orthologous to human ZNF609 (zinc finger protein 609). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 8.8), CNS E14 (RPKM 8.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 C; 9 35.46 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (65598860..65735004, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (65691578..65827564, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircZNF609 regulates pulmonary fibrosis via miR-145-5p/KLF4 axis and its translation function.
Title: CircZNF609 regulates pulmonary fibrosis via miR-145-5p/KLF4 axis and its translation function.
Zfp609 circular RNA regulates myoblast differentiation by sponging miR-194-5p
Title: A Zfp609 circular RNA regulates myoblast differentiation by sponging miR-194-5p.
Depletion of Zfp609 or Nipbl from cortical neural progenitors in vivo is detrimental to neuronal migration. Zfp609 and Nipbl overlap at genomic binding sites independently of cohesin and regulate genes that control cortical neuron migration.
Title: Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration.
Zfp609 is necessary for Rag1 and Rag2 expression in developing thymocytes.
Title: Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

13.MMHAP4FLE1.seq (e-PCR)
- UniSTS:123170

40.MHAa92d4.seq (e-PCR)
- UniSTS:124352

NoName (e-PCR)
- UniSTS:493563

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell differentiation in thymus	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of myoblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of myoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein 609

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172536.3 → NP_766124.2 zinc finger protein 609

See identical proteins and their annotated locations for NP_766124.2

Status: VALIDATED

Source sequence(s)

AC121979, AK036715, BC016271, BC058943, BF465900

Consensus CDS

CCDS23297.2

UniProtKB/Swiss-Prot

Q05DD7, Q6PD47, Q6ZQE3, Q8BZ47

UniProtKB/TrEMBL

B2RWS7

Related

ENSMUSP00000124089.2, ENSMUST00000159109.2

Conserved Domains (2) summary

PTZ00449
Location:1005 → 1228

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

COG5189
Location:412 → 533

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

65598860..65735004 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154823.1 → XP_036010716.1 zinc finger protein 609 isoform X3

UniProtKB/TrEMBL

B2RWS7

Conserved Domains (1) summary

COG5189
Location:163 → 284

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
XM_006511007.5 → XP_006511070.1 zinc finger protein 609 isoform X2

UniProtKB/TrEMBL

B2RWS7

Conserved Domains (2) summary

PTZ00449
Location:776 → 999

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

COG5189
Location:183 → 304

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
XM_036154822.1 → XP_036010715.1 zinc finger protein 609 isoform X1

UniProtKB/TrEMBL

B2RWS7

Conserved Domains (2) summary

PTZ00449
Location:1005 → 1228

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

COG5189
Location:412 → 533

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]