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Chadl chondroadherin-like [ Mus musculus (house mouse) ]

Gene ID: 214685, updated on 5-Mar-2024

Summary

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Official Symbol
Chadlprovided by MGI
Official Full Name
chondroadherin-likeprovided by MGI
Primary source
MGI:MGI:3036284
See related
Ensembl:ENSMUSG00000063765 AllianceGenome:MGI:3036284
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D930017K21Rik
Summary
Predicted to enable collagen binding activity and collagen fibril binding activity. Involved in negative regulation of chondrocyte differentiation. Located in collagen-containing extracellular matrix. Is expressed in ureteric tip. Orthologous to human CHADL (chondroadherin like). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: We previously annotated two pseudogenes overlapping this gene, based on predictions from pseudogene.org. Our curation indicates that this locus is protein-coding. [28 Nov 2011]
Expression
Broad expression in limb E14.5 (RPKM 16.9), adrenal adult (RPKM 6.8) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E1; 15 38.2 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81570366..81581564, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81686166..81697373, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene E1A binding protein p300 Neighboring gene predicted gene, 22067 Neighboring gene STARR-positive B cell enhancer ABC_E2446 Neighboring gene L3MBTL2 polycomb repressive complex 1 subunit Neighboring gene TM2 domain containing 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_39263 Neighboring gene RAN GTPase activating protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1915 Neighboring gene zinc finger CCCH type containing 7B Neighboring gene STARR-seq mESC enhancer starr_39269

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Engineered viruses to select genes encoding secreted and membrane-bound proteins in mammalian cells. Moffatt P, et al. Nucleic Acids Res, 2002 Oct 1. PMID 12364608, Free PMC Article
  2. The novel small leucine-rich protein chondroadherin-like (CHADL) is expressed in cartilage and modulates chondrocyte differentiation. Tillgren V, et al. J Biol Chem, 2015 Jan 9. PMID 25451920, Free PMC Article
  3. Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Rutledge EA, et al. Development, 2017 Sep 1. PMID 28705898, Free PMC Article
  4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding ISO
Inferred from Sequence Orthology
more info
  
enables collagen fibril binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of collagen fibril organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
chondroadherin-like protein
Names
chondroadherin pseudogene
leucine rich repeat containing 15 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164320.1 → NP_001157792.1  chondroadherin-like protein precursor

    See identical proteins and their annotated locations for NP_001157792.1

    Status: PROVISIONAL

    Source sequence(s)
    AC102262
    Consensus CDS
    CCDS49677.1
    UniProtKB/Swiss-Prot
    E9Q7T7
    Related
    ENSMUSP00000072682.6, ENSMUST00000072910.6
    Conserved Domains (6) summary
    smart00013
    Location:32 → 64
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:674 → 722
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:411 → 602
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:426 → 449
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:642 → 675
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:158 → 217
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    81570366..81581564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520742.5 → XP_006520805.1  chondroadherin-like protein isoform X1

    Conserved Domains (6) summary
    PRK15370
    Location:32 → 322
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00013
    Location:405 → 439
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:685 → 733
    LRRCT; Leucine rich repeat C-terminal domain
    COG4886
    Location:507 → 687
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:437 → 460
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:169 → 228
    LRR_8; Leucine rich repeat

  2. XM_030248458.2 → XP_030104318.1  chondroadherin-like protein isoform X2

    Conserved Domains (5) summary
    PRK15370
    Location:21 → 311
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00013
    Location:394 → 428
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:465 → 625
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:63 → 86
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:158 → 217
    LRR_8; Leucine rich repeat

RNA

  1. XR_383996.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_020216.1: Suppressed sequence

    Description
    NG_020216.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.

  2. NG_020217.1: Suppressed sequence

    Description
    NG_020217.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q7T7.1 GenPept UniProtKB/Swiss-Prot:E9Q7T7

Gene LinkOut

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