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Cped1 cadherin-like and PC-esterase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 214642, updated on 3-Apr-2024

Summary

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Official Symbol
Cped1provided by MGI
Official Full Name
cadherin-like and PC-esterase domain containing 1provided by MGI
Primary source
MGI:MGI:2444814
See related
Ensembl:ENSMUSG00000062980 AllianceGenome:MGI:2444814
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6720481P07; A430107O13Rik
Summary
Predicted to be located in endoplasmic reticulum. Is expressed in several structures, including gut; limb segment; lung; meninges; and skin. Orthologous to human CPED1 (cadherin like and PC-esterase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 13.7), bladder adult (RPKM 10.2) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 A3.1; 6 8.86 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (21985875..22256406)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (21985710..22256407)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene tetraspanin 12 Neighboring gene predicted gene, 30270 Neighboring gene STARR-positive B cell enhancer ABC_E676 Neighboring gene STARR-positive B cell enhancer ABC_E6418 Neighboring gene inhibitor of growth family, member 3 Neighboring gene STARR-seq mESC enhancer starr_15304 Neighboring gene STARR-seq mESC enhancer starr_15305 Neighboring gene STARR-seq mESC enhancer starr_15306 Neighboring gene STARR-seq mESC enhancer starr_15307 Neighboring gene STARR-seq mESC enhancer starr_15308 Neighboring gene 60S ribosomal protein L32 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15309 Neighboring gene predicted gene 42573 Neighboring gene STARR-seq mESC enhancer starr_15310 Neighboring gene wingless-type MMTV integration site family, member 16 Neighboring gene FAM3 metabolism regulating signaling molecule C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Multiple Mechanisms Explain Genetic Effects at the CPED1-WNT16 Bone Mineral Density Locus. Gómez AE, et al. Curr Osteoporos Rep, 2023 Apr. PMID 36943599, Free PMC Article
  2. Characterization of expression and alternative splicing of the gene cadherin-like and PC esterase domain containing 1 (Cped1). Maynard RD, et al. Gene, 2018 Oct 20. PMID 29935354, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Multiple Mechanisms Explain Genetic Effects at the CPED1-WNT16 Bone Mineral Density Locus.
    Title: Multiple Mechanisms Explain Genetic Effects at the CPED1-WNT16 Bone Mineral Density Locus.
  2. Some of the first data describing expression and alternative splicing of Cped1.
    Title: Characterization of expression and alternative splicing of the gene cadherin-like and PC esterase domain containing 1 (Cped1).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cadherin-like and PC-esterase domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081351.2 → NP_001074820.1  cadherin-like and PC-esterase domain-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_001074820.1

    Status: VALIDATED

    Source sequence(s)
    AC115039, AC117213, AC133955
    Consensus CDS
    CCDS39435.1
    UniProtKB/TrEMBL
    A0A2Z4MSH0, B2RX70
    Related
    ENSMUSP00000111041.3, ENSMUST00000115383.9
    Conserved Domains (1) summary
    pfam12733
    Location:578 → 663
    Cadherin-like; Cadherin-like beta sandwich domain

  2. NM_001418022.1 → NP_001404951.1  cadherin-like and PC-esterase domain-containing protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC115039, AC117213, AC133955
    UniProtKB/TrEMBL
    B2RX70

  3. NM_001418023.1 → NP_001404952.1  cadherin-like and PC-esterase domain-containing protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC117213, AC133955

  4. NM_001418024.1 → NP_001404953.1  cadherin-like and PC-esterase domain-containing protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC115039, AC117213, AC133955
    UniProtKB/TrEMBL
    A0A2Z4MSG2

  5. NM_001418025.1 → NP_001404954.1  cadherin-like and PC-esterase domain-containing protein 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC115039, AC117213, AC133955
    Related
    ENSMUSP00000119808.3, ENSMUST00000137437.6

  6. NM_001418026.1 → NP_001404955.1  cadherin-like and PC-esterase domain-containing protein 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC117213, AC133955

  7. NM_001418027.1 → NP_001404956.1  cadherin-like and PC-esterase domain-containing protein 1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC117213, AC133955

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    21985875..22256406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166012.1 → XP_036021905.1  cadherin-like and PC-esterase domain-containing protein 1 isoform X4

    Conserved Domains (1) summary
    pfam12733
    Location:577 → 663
    Cadherin-like; Cadherin-like beta sandwich domain

  2. XM_006505040.5 → XP_006505103.1  cadherin-like and PC-esterase domain-containing protein 1 isoform X3

    Conserved Domains (1) summary
    pfam12733
    Location:578 → 663
    Cadherin-like; Cadherin-like beta sandwich domain

  3. XM_006505042.5 → XP_006505105.1  cadherin-like and PC-esterase domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    Q8BMB4
    Conserved Domains (1) summary
    pfam12733
    Location:270 → 355
    Cadherin-like; Cadherin-like beta sandwich domain

RNA

  1. XR_004942929.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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