U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tcp10a t-complex protein 10a [ Mus musculus (house mouse) ]

Gene ID: 21461, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Tcp10aprovided by MGI
Official Full Name
t-complex protein 10aprovided by MGI
Primary source
MGI:MGI:98541
See related
Ensembl:ENSMUSG00000071322 AllianceGenome:MGI:98541
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
T66A-a; Gm10326; Tcp-10a; D17Leh66A; D17Leh66aa
Summary
Predicted to enable several functions, including identical protein binding activity; protein self-association; and transcription corepressor activity. Predicted to be active in centriole and nucleus. Orthologous to several human genes including TCP10L (t-complex 10 like) and TCP10L2 (t-complex 10 like 2, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 142.0) See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17 4.72 cM; 17 A1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (7592055..7613259)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (7324656..7345860)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41745 Neighboring gene ribosomal protein S6 kinase, polypeptide 2 Neighboring gene STARR-positive B cell enhancer mm9_chr17:7374004-7374305 Neighboring gene STARR-seq mESC enhancer starr_41746 Neighboring gene VISTA enhancer mm108 Neighboring gene STARR-seq mESC enhancer starr_41751 Neighboring gene G protein-coupled receptor 31, D17Leh66a region Neighboring gene tubulin tyrosine ligase-like family, member 2 Neighboring gene unc-93 homolog A2 Neighboring gene predicted gene, 26057

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Functional and molecular characterization of the transcriptional regulatory region of Tcp-10bt, a testes-expressed gene from the t complex responder locus. Ewulonu UK, et al. Development, 1993 Jan. PMID 8223262
  2. Concerted evolution of the mouse Tcp-10 gene family: implications for the functional basis of t haplotype transmission ratio distortion. Pilder SH, et al. Genomics, 1992 Jan. PMID 1339385
  3. Targeted mutagenesis of a candidate t complex responder gene in mouse t haplotypes does not eliminate transmission ratio distortion. Ewulonu UK, et al. Genetics, 1996 Oct. PMID 8889539, Free PMC Article
  4. The human homolog of a candidate mouse t complex responder gene: conserved motifs and evolution with punctuated equilibria. Islam SD, et al. Hum Mol Genet, 1993 Dec. PMID 8111376
  5. An unstable family of large DNA elements in the center of the mouse t complex. Schimenti J, et al. J Mol Biol, 1987 Apr 20. PMID 2821263

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC184383

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
t-complex protein 10a

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011553.4 → NP_035683.2  t-complex protein 10a

    See identical proteins and their annotated locations for NP_035683.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript.
    Source sequence(s)
    AC117241, AK161455
    Consensus CDS
    CCDS28377.1
    UniProtKB/TrEMBL
    B2RUN1, Q80W76
    Related
    ENSMUSP00000093394.5, ENSMUST00000095726.11
    Conserved Domains (2) summary
    pfam07202
    Location:263 → 436
    Tcp10_C; T-complex protein 10 C-terminus
    pfam15030
    Location:19 → 103
    DUF4527; Protein of unknown function (DUF4527)

RNA

  1. NR_046291.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' end, compared to variant 1, resulting in a longer transcript. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC117241, BC052353

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    7592055..7613259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523213.3 → XP_006523276.1  t-complex protein 10a isoform X1

    UniProtKB/TrEMBL
    B2RUN1
    Conserved Domains (1) summary
    pfam07202
    Location:230 → 404
    Tcp10_C; T-complex protein 10 C-terminus
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous