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Slc10a3 solute carrier family 10 (sodium/bile acid cotransporter family), member 3 [ Mus musculus (house mouse) ]

Gene ID: 214601, updated on 5-Mar-2024

Summary

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Official Symbol
Slc10a3provided by MGI
Official Full Name
solute carrier family 10 (sodium/bile acid cotransporter family), member 3provided by MGI
Primary source
MGI:MGI:95048
See related
Ensembl:ENSMUSG00000032806 AllianceGenome:MGI:95048
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P3; DXS253Eh; DXSmhG28; DXHXS253E
Summary
Predicted to enable bile acid:sodium symporter activity. Acts upstream of or within response to retinoic acid. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain ventricle and choroid plexus; facial bone primordium; genitourinary system; integumental system; and lung. Orthologous to human SLC10A3 (solute carrier family 10 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 25.9), mammary gland adult (RPKM 21.6) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Slc10a3 in Genome Data Viewer
Location:
X A7.3; X 38.0 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73412823..73416955, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74369217..74373349, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene L antigen family, member 3 Neighboring gene predicted readthrough transcript (NMD candidate), 44504 Neighboring gene ubiquitin-like 4A Neighboring gene FAM3 metabolism regulating signaling molecule A Neighboring gene STARR-seq mESC enhancer starr_47367 Neighboring gene inhibitor of kappaB kinase gamma Neighboring gene glucose-6-phosphate dehydrogenase X-linked Neighboring gene STARR-positive B cell enhancer ABC_E11050

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sequence analysis of two exons from the murine dystrophin locus. Maconochie MK, et al. Mamm Genome, 1992. PMID 1543903
  2. CpG islands of the X chromosome are gene associated. Alcalay M, et al. Nucleic Acids Res, 1988 Oct 25. PMID 3186440, Free PMC Article
  3. Pulse-field linkage of the P3, G6pd and Cf-8 genes on the mouse X chromosome: demonstration of synteny at the physical level. Brockdorff N, et al. Nucleic Acids Res, 1989 Feb 25. PMID 2922282, Free PMC Article
  4. Extension of the physical map in the region of the mouse X chromosome homologous to human Xq28 and identification of an exception to conserved linkage. Faust CJ, et al. Genomics, 1992 Aug. PMID 1354645
  5. Linkage and sequence conservation of the X-linked genes DXS253E (P3) and DXS254E (GdX) in mouse and man. Filippi M, et al. Genomics, 1990 Jul. PMID 1973144

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Readthrough Gm44504

Readthrough gene: Gm44504, Included gene: Ubl4a

Homology

Clone Names

  • MGC36271, MGC38638

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables bile acid:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bile acid and bile salt transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to organic substance IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to retinoic acid IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
P3 protein
Names
protein P3
solute carrier family 10, member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256104.1 → NP_001243033.1  P3 protein precursor

    See identical proteins and their annotated locations for NP_001243033.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK041958, AL807376, AW493539, BM939642, CN723057
    Consensus CDS
    CCDS30231.1
    UniProtKB/Swiss-Prot
    P21129, Q8QZR2
    UniProtKB/TrEMBL
    A0A158SIT6, J3JSA1
    Related
    ENSMUSP00000072818.5, ENSMUST00000073067.11
    Conserved Domains (1) summary
    TIGR00841
    Location:197 → 470
    bass; bile acid transporter

  2. NM_145406.2 → NP_663381.1  P3 protein precursor

    See identical proteins and their annotated locations for NP_663381.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK041958, AL807376, AW493539, BM939642
    Consensus CDS
    CCDS30231.1
    UniProtKB/Swiss-Prot
    P21129, Q8QZR2
    UniProtKB/TrEMBL
    A0A158SIT6, J3JSA1
    Related
    ENSMUSP00000045150.6, ENSMUST00000037967.6
    Conserved Domains (1) summary
    TIGR00841
    Location:197 → 470
    bass; bile acid transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    73412823..73416955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21129.2 GenPept UniProtKB/Swiss-Prot:P21129

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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