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Cdc73 cell division cycle 73, Paf1/RNA polymerase II complex component [ Mus musculus (house mouse) ]

Gene ID: 214498, updated on 11-Apr-2024

Summary

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Official Symbol
Cdc73provided by MGI
Official Full Name
cell division cycle 73, Paf1/RNA polymerase II complex componentprovided by MGI
Primary source
MGI:MGI:2384876
See related
Ensembl:ENSMUSG00000026361 AllianceGenome:MGI:2384876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hrpt2; 8430414L16Rik; C130030P16Rik
Summary
Predicted to enable RNA polymerase II complex binding activity. Involved in several processes, including cellular response to lipopolysaccharide; endodermal cell fate commitment; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of apoptotic process; regulation of cell growth; and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Cdc73/Paf1 complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Used to study hyperparathyroidism. Human ortholog(s) of this gene implicated in hyperparathyroidism and parathyroid carcinoma. Orthologous to human CDC73 (cell division cycle 73). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 8.5), CNS E11.5 (RPKM 3.0) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Cdc73 in Genome Data Viewer
Location:
1 F; 1 62.52 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (143479014..143578631, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (143603276..143702893, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35244 Neighboring gene STARR-seq mESC enhancer starr_02523 Neighboring gene STARR-seq mESC enhancer starr_02525 Neighboring gene STARR-seq mESC enhancer starr_02526 Neighboring gene predicted gene, 35303 Neighboring gene UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 Neighboring gene STARR-positive B cell enhancer ABC_E7755 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02529 Neighboring gene predicted gene, 38658 Neighboring gene predicted gene, 46161 Neighboring gene glutaredoxin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mice deleted for cell division cycle 73 gene develop parathyroid and uterine tumours: model for the hyperparathyroidism-jaw tumour syndrome. Walls GV, et al. Oncogene, 2017 Jul 13. PMID 28288139, Free PMC Article
  2. The PAF1c Subunit CDC73 Is Required for Mouse Hematopoietic Stem Cell Maintenance but Displays Leukemia-Specific Gene Regulation. Saha N, et al. Stem Cell Reports, 2019 May 14. PMID 31031188, Free PMC Article
  3. MLL fusion protein-driven AML is selectively inhibited by targeted disruption of the MLL-PAFc interaction. Muntean AG, et al. Blood, 2013 Sep 12. PMID 23900238, Free PMC Article
  4. Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression. Woodard GE, et al. Oncogene, 2005 Feb 10. PMID 15580289
  5. Osteoblast-specific deletion of Hrpt2/Cdc73 results in high bone mass and increased bone turnover. Droscha CJ, et al. Bone, 2017 May. PMID 28384511

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cell division cycle 73 (CDC73) Is esential for embryonic and adult matopoiesis and Indispensable for acute myeloid leukemia (AML)
    Title: The PAF1c Subunit CDC73 Is Required for Mouse Hematopoietic Stem Cell Maintenance but Displays Leukemia-Specific Gene Regulation.
  2. Uterine neoplasms, myometria and jaw bones of Cdc73(+/-) mice had increased proliferation rates that were 2-fold higher than in Cdc73(+/+) mice.
    Title: Mice deleted for cell division cycle 73 gene develop parathyroid and uterine tumours: model for the hyperparathyroidism-jaw tumour syndrome.
  3. These results aid in our understanding of the role parafibromin plays within transcriptional regulation, terminal differentiation, and bone homeostasis
    Title: Osteoblast-specific deletion of Hrpt2/Cdc73 results in high bone mass and increased bone turnover.
  4. Data indicate that isruption of the MLL-PAFc subunit, Cdc73 (Hrpt2) interaction selectively inhibits the proliferation of MLL leukemic cells.
    Title: MLL fusion protein-driven AML is selectively inhibited by targeted disruption of the MLL-PAFc interaction.
  5. Oncogenic microRNA-155 down-regulates tumor suppressor CDC73 and promotes oral squamous cell carcinoma cell proliferation
    Title: Oncogenic microRNA-155 down-regulates tumor suppressor CDC73 and promotes oral squamous cell carcinoma cell proliferation: implications for cancer therapeutics.
  6. Expression of Hrpt2 and parafibromin is pivotal in mammalian development and survival in adults and that these functions are likely mediated by the transcriptional regulation of growth factors.
    Title: Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC29274, MGC36559

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endodermal cell fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cdc73/Paf1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cdc73/Paf1 complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
parafibromin
Names
cell division cycle protein 73 homolog
hyperparathyroidism 2 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145991.2 → NP_666103.1  parafibromin

    See identical proteins and their annotated locations for NP_666103.1

    Status: VALIDATED

    Source sequence(s)
    AK048027, AK080861, AK134896, AK153645, AL592403, BB645172
    Consensus CDS
    CCDS15341.1
    UniProtKB/Swiss-Prot
    Q8JZM7
    Related
    ENSMUSP00000018337.8, ENSMUST00000018337.9
    Conserved Domains (2) summary
    pfam05179
    Location:357 → 520
    CDC73_C; RNA pol II accessory factor, Cdc73 family, C-terminal
    pfam16050
    Location:1 → 297
    CDC73_N; Paf1 complex subunit CDC73 N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    143479014..143578631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529366.4 → XP_006529429.1  parafibromin isoform X2

    Conserved Domains (1) summary
    pfam16050
    Location:1 → 297
    CDC73_N; Paf1 complex subunit CDC73 N-terminal

  2. XM_006529365.2 → XP_006529428.1  parafibromin isoform X1

    Conserved Domains (1) summary
    pfam16050
    Location:1 → 297
    CDC73_N; Paf1 complex subunit CDC73 N-terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JZM7.1 GenPept UniProtKB/Swiss-Prot:Q8JZM7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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