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Fnbp1l formin binding protein 1-like [ Mus musculus (house mouse) ]

Gene ID: 214459, updated on 21-Apr-2024

Summary

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Official Symbol
Fnbp1lprovided by MGI
Official Full Name
formin binding protein 1-likeprovided by MGI
Primary source
MGI:MGI:1925642
See related
Ensembl:ENSMUSG00000039735 AllianceGenome:MGI:1925642
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TOCA1; toca-1; 2610318I01Rik
Summary
Predicted to enable GTPase binding activity. Predicted to be involved in several processes, including plasma membrane tubulation; positive regulation of filopodium assembly; and vesicle transport along actin filament. Predicted to act upstream of or within cilium assembly. Predicted to be located in cytoplasmic vesicle and cytosol. Is expressed in central nervous system; dorsal root ganglion; gut; male reproductive gland or organ; and neural retina. Orthologous to human FNBP1L (formin binding protein 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 92.2), CNS E14 (RPKM 86.3) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 G1; 3 53.63 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (122332368..122413363, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (122538719..122619714, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2681 Neighboring gene STARR-positive B cell enhancer ABC_E9224 Neighboring gene STARR-positive B cell enhancer ABC_E11214 Neighboring gene predicted gene, 57718 Neighboring gene STARR-positive B cell enhancer ABC_E6115 Neighboring gene breast cancer anti-estrogen resistance 3 Neighboring gene STARR-positive B cell enhancer mm9_chr3:122165198-122165499 Neighboring gene STARR-seq mESC enhancer starr_08882 Neighboring gene STARR-seq mESC enhancer starr_08885 Neighboring gene predicted gene, 34349 Neighboring gene microRNA 7657 Neighboring gene STARR-seq mESC enhancer starr_08890 Neighboring gene STARR-seq mESC enhancer starr_08892 Neighboring gene predicted gene 43568 Neighboring gene eptidyl-prolyl cis-trans isomerase A pseudogene 3_2252.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Myogenesis defect due to Toca-1 knockdown can be suppressed by expression of N-WASP. George B, et al. Biochim Biophys Acta, 2014 Sep. PMID 24861867
  2. Identification and characterization of human FNBP1L gene in silico. Katoh M, et al. Int J Mol Med, 2004 Jan. PMID 14654988
  3. miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Cao J, et al. Nat Cell Biol, 2012 Jun 10. PMID 22684256
  4. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
  5. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC30506

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane invagination ISO
Inferred from Sequence Orthology
more info
  
involved_in plasma membrane tubulation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle budding from membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle organization ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle transport along actin filament ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
formin-binding protein 1-like
Names
transducer of Cdc42-dependent actin assembly protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114665.2 → NP_001108137.1  formin-binding protein 1-like isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC099584, AC138720
    Consensus CDS
    CCDS51062.1
    UniProtKB/TrEMBL
    A0A5F8MPQ8, E9PUI5
    Related
    ENSMUSP00000124947.2, ENSMUST00000162947.3
    Conserved Domains (3) summary
    cd07675
    Location:5 → 256
    F-BAR_FNBP1L; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 1-Like
    cd11628
    Location:399 → 479
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
    cd12072
    Location:541 → 597
    SH3_FNBP1L; Src Homology 3 domain of Formin Binding Protein 1-Like

  2. NM_153118.3 → NP_694758.2  formin-binding protein 1-like isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the coding region compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC099584, AC138720
    Consensus CDS
    CCDS17811.2
    UniProtKB/TrEMBL
    A0A5F8MPQ8, E9PUK3
    Related
    ENSMUSP00000124439.2, ENSMUST00000162409.8
    Conserved Domains (3) summary
    cd07675
    Location:5 → 256
    F-BAR_FNBP1L; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 1-Like
    cd11628
    Location:341 → 421
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
    cd12072
    Location:483 → 539
    SH3_FNBP1L; Src Homology 3 domain of Formin Binding Protein 1-Like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    122332368..122413363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K012.2 GenPept UniProtKB/Swiss-Prot:Q8K012

Gene LinkOut

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