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Cilp cartilage intermediate layer protein, nucleotide pyrophosphohydrolase [ Mus musculus (house mouse) ]

Gene ID: 214425, updated on 5-Mar-2024

Summary

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Official Symbol
Cilpprovided by MGI
Official Full Name
cartilage intermediate layer protein, nucleotide pyrophosphohydrolaseprovided by MGI
Primary source
MGI:MGI:2444507
See related
Ensembl:ENSMUSG00000042254 AllianceGenome:MGI:2444507
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CILP-1; 9830114D16; C130036G17Rik
Summary
Predicted to be involved in cellular response to transforming growth factor beta stimulus; negative regulation of gene expression; and negative regulation of signal transduction. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including diaphragm; lower lip; musculoskeletal system; spleen; and tongue. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human CILP (cartilage intermediate layer protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in genital fat pad adult (RPKM 10.5), subcutaneous fat pad adult (RPKM 8.2) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 C; 9 35.2 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65172462..65187896)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65265180..65280614)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2894 Neighboring gene predicted gene, 40527 Neighboring gene RNA, U5G small nuclear Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:65064991-65065144 Neighboring gene poly (ADP-ribose) polymerase family, member 16 Neighboring gene predicted gene, 36538 Neighboring gene STARR-seq mESC enhancer starr_24450 Neighboring gene STARR-positive B cell enhancer ABC_E5079 Neighboring gene predicted gene 16218 Neighboring gene caseinolytic mitochondrial matrix peptidase chaperone subunit Neighboring gene predicted gene, 19219

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Matricellular Protein Cilp1 Promotes Myocardial Fibrosis in Response to Myocardial Infarction. Zhang QJ, et al. Circ Res, 2021 Nov 12. PMID 34610755, Free PMC Article
  2. Cartilage intermediate layer protein-1 alleviates pressure overload-induced cardiac fibrosis via interfering TGF-β1 signaling. Zhang CL, et al. J Mol Cell Cardiol, 2018 Mar. PMID 29438665
  3. Cartilage intermediate layer protein promotes lumbar disc degeneration. Seki S, et al. Biochem Biophys Res Commun, 2014 Apr 18. PMID 24631904
  4. Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis. Bernardo BC, et al. J Biol Chem, 2011 Oct 28. PMID 21880736, Free PMC Article
  5. Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways. Rolfe RA, et al. BMC Genomics, 2014 Jan 20. PMID 24443808, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Matricellular Protein Cilp1 Promotes Myocardial Fibrosis in Response to Myocardial Infarction.
    Title: Matricellular Protein Cilp1 Promotes Myocardial Fibrosis in Response to Myocardial Infarction.
  2. CILP-1 is a novel extracellular matrix protein possessing anti-fibrotic ability in pressure overload-induced fibrotic remodeling.
    Title: Cartilage intermediate layer protein-1 alleviates pressure overload-induced cardiac fibrosis via interfering TGF-β1 signaling.
  3. Overexpression of CILP in the nucleus pulposus cells promotes disc degeneration, indicating that CILP plays a direct role in the pathogenesis of lumbar disc disease.
    Title: Cartilage intermediate layer protein promotes lumbar disc degeneration.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cartilage intermediate layer protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364527.1 → NP_001351456.1  cartilage intermediate layer protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC110235
    UniProtKB/Swiss-Prot
    Q66K08, Q7TSS0, Q7TSS1, Q8BV01
    Conserved Domains (3) summary
    smart00209
    Location:53 → 101
    TSP1; Thrombospondin type 1 repeats
    pfam13330
    Location:1 → 40
    Mucin2_WxxW; Mucin-2 protein WxxW repeating region
    pfam13927
    Location:210 → 279
    Ig_3; Immunoglobulin domain

  2. NM_173385.3 → NP_775561.1  cartilage intermediate layer protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_775561.1

    Status: VALIDATED

    Source sequence(s)
    AC110235, AK081544
    Consensus CDS
    CCDS23287.1
    UniProtKB/Swiss-Prot
    Q66K08, Q7TSS0, Q7TSS1, Q8BV01
    UniProtKB/TrEMBL
    A0A0R4J0F8
    Related
    ENSMUSP00000036631.2, ENSMUST00000048762.8
    Conserved Domains (5) summary
    smart00408
    Location:323 → 383
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:152 → 200
    TSP1; Thrombospondin type 1 repeats
    smart00410
    Location:321 → 394
    IG_like; Immunoglobulin like
    pfam13330
    Location:55 → 139
    Mucin2_WxxW; Mucin-2 protein WxxW repeating region
    pfam13715
    Location:492 → 580
    CarbopepD_reg_2; CarboxypepD_reg-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    65172462..65187896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66K08.1 GenPept UniProtKB/Swiss-Prot:Q66K08

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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