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Hhipl1 hedgehog interacting protein-like 1 [ Mus musculus (house mouse) ]

Gene ID: 214305, updated on 5-Mar-2024

Summary

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Official Symbol
Hhipl1provided by MGI
Official Full Name
hedgehog interacting protein-like 1provided by MGI
Primary source
MGI:MGI:1919265
See related
Ensembl:ENSMUSG00000021260 AllianceGenome:MGI:1919265
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1822; 1600002O04Rik
Summary
Predicted to enable catalytic activity and scavenger receptor activity. Predicted to be located in extracellular region and membrane. Is expressed in adrenal gland; cartilage; nervous system; stomach; and testis. Orthologous to human HHIPL1 (HHIP like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 2.7), ovary adult (RPKM 2.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Hhipl1 in Genome Data Viewer
Location:
12 F1; 12 59.37 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (108272100..108294559)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (108305968..108328300)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene SET domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E743 Neighboring gene cyclin K Neighboring gene coiled-coil domain containing 85C Neighboring gene STARR-positive B cell enhancer mm9_chr12:109513689-109513989 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109514813-109514922 Neighboring gene STARR-positive B cell enhancer mm9_chr12:109572195-109572495 Neighboring gene cytochrome P450, family 46, subfamily a, polypeptide 1 Neighboring gene echinoderm microtubule associated protein like 1 Neighboring gene bridging integrator 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. HHIPL1, a Gene at the 14q32 Coronary Artery Disease Locus, Positively Regulates Hedgehog Signaling and Promotes Atherosclerosis. Aravani D, et al. Circulation, 2019 Aug 6. PMID 31163988, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

General gene information

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Homology

Clone Names

  • KIAA1822

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
HHIP-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044380.1 → NP_001037845.1  HHIP-like protein 1 precursor

    See identical proteins and their annotated locations for NP_001037845.1

    Status: PROVISIONAL

    Source sequence(s)
    BC113163
    Consensus CDS
    CCDS36554.1
    UniProtKB/Swiss-Prot
    Q14CI0, Q14DK5, Q3UGD3, Q3UU97, Q6ZPH6
    Related
    ENSMUSP00000021685.7, ENSMUST00000021685.8
    Conserved Domains (4) summary
    smart00202
    Location:682 → 785
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:689 → 785
    SRCR; Scavenger receptor cysteine-rich domain
    pfam03024
    Location:42 → 189
    Folate_rec; Folate receptor family
    pfam07995
    Location:199 → 445
    GSDH; Glucose / Sorbosone dehydrogenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    108272100..108294559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515665.5 → XP_006515728.1  HHIP-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q14DK5
    Conserved Domains (2) summary
    pfam03024
    Location:42 → 189
    Folate_rec; Folate receptor family
    cl26817
    Location:199 → 445
    GSDH; Glucose / Sorbosone dehydrogenase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14DK5.1 GenPept UniProtKB/Swiss-Prot:Q14DK5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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