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Tfec transcription factor EC [ Mus musculus (house mouse) ]

Gene ID: 21426, updated on 11-Apr-2024

Summary

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Official Symbol
Tfecprovided by MGI
Official Full Name
transcription factor ECprovided by MGI
Primary source
MGI:MGI:1333760
See related
Ensembl:ENSMUSG00000029553 AllianceGenome:MGI:1333760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tcfec; bHLHe34
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to heat. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; esophagus; intestine; male reproductive gland or organ; and urinary system. Orthologous to human TFEC (transcription factor EC). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 1.9), liver E18 (RPKM 1.4) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Tfec in Genome Data Viewer
Location:
6 A2; 6 7.61 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (16830926..16898463, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (16830927..16898464, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15244 Neighboring gene predicted gene, 36503 Neighboring gene STARR-seq mESC enhancer starr_15245 Neighboring gene STARR-seq mESC enhancer starr_15246 Neighboring gene STARR-seq mESC enhancer starr_15247 Neighboring gene predicted gene, 36669 Neighboring gene STARR-seq mESC enhancer starr_15248 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2776 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:17015482-17015727 Neighboring gene predicted gene 15473 Neighboring gene testin LIM domain protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors. Rehli M, et al. J Immunol, 1999 Feb 1. PMID 9973413
  2. Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor. Rehli M, et al. J Immunol, 2005 Jun 1. PMID 15908341
  3. Role of C/EBP homologous protein and endoplasmic reticulum stress in asthma exacerbation by regulating the IL-4/signal transducer and activator of transcription 6/transcription factor EC/IL-4 receptor α positive feedback loop in M2 macrophages. Wang Y, et al. J Allergy Clin Immunol, 2017 Dec. PMID 28238747
  4. TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation. Zhao GQ, et al. Mol Cell Biol, 1993 Aug. PMID 8336698, Free PMC Article
  5. Cloning and characterization of the murine genes for bHLH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members. Rehli M, et al. Genomics, 1999 Feb 15. PMID 10036191

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tfec transcribes IL-4 receptor alpha expression to promote M2 programming in macrophages
    Title: Role of C/EBP homologous protein and endoplasmic reticulum stress in asthma exacerbation by regulating the IL-4/signal transducer and activator of transcription 6/transcription factor EC/IL-4 receptor α positive feedback loop in M2 macrophages.
  2. Data indicate that FOS, SPI1, KLF10, TFEC, and PRDM16 show robust transcriptional cross-regulation and are often associated with osteoclastogenesis.
    Title: Identification of non-cell-autonomous networks from engineered feeder cells that enhance murine hematopoietic stem cell activity.
  3. Transcription factor EC, along with several other transcription factors, is a Stat6-dependent target of IL-4.
    Title: Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107474

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription factor EC
Names
TFE-C
mTFEC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031198.3 → NP_112475.1  transcription factor EC

    See identical proteins and their annotated locations for NP_112475.1

    Status: VALIDATED

    Source sequence(s)
    AC102663, AK137141
    Consensus CDS
    CCDS19920.1
    UniProtKB/Swiss-Prot
    Q3TWR7, Q9WTW4
    Related
    ENSMUSP00000031533.8, ENSMUST00000031533.11
    Conserved Domains (3) summary
    cd00083
    Location:108 → 168
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:196 → 300
    DUF3371; Domain of unknown function (DUF3371)
    cl21462
    Location:164 → 195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    16830926..16898463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241053.3 → XP_011239355.1  transcription factor EC isoform X2

    Conserved Domains (2) summary
    pfam11851
    Location:213 → 317
    DUF3371; Domain of unknown function (DUF3371)
    cl00081
    Location:148 → 219
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  2. XM_006505035.5 → XP_006505098.1  transcription factor EC isoform X1

    Conserved Domains (2) summary
    pfam11851
    Location:232 → 336
    DUF3371; Domain of unknown function (DUF3371)
    cd18926
    Location:135 → 238
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

  3. XM_017321504.2 → XP_017176993.1  transcription factor EC isoform X4

    Conserved Domains (2) summary
    pfam11851
    Location:97 → 201
    DUF3371; Domain of unknown function (DUF3371)
    cl00081
    Location:32 → 103
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  4. XM_006505036.4 → XP_006505099.1  transcription factor EC isoform X3

    Conserved Domains (2) summary
    pfam11851
    Location:158 → 262
    DUF3371; Domain of unknown function (DUF3371)
    cd18926
    Location:61 → 164
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

  5. XM_006505037.4 → XP_006505100.1  transcription factor EC isoform X4

    Conserved Domains (2) summary
    pfam11851
    Location:97 → 201
    DUF3371; Domain of unknown function (DUF3371)
    cl00081
    Location:32 → 103
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTW4.1 GenPept UniProtKB/Swiss-Prot:Q9WTW4

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