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Pak6 p21 (RAC1) activated kinase 6 [ Mus musculus (house mouse) ]

Gene ID: 214230, updated on 11-Apr-2024

Summary

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Official Symbol
Pak6provided by MGI
Official Full Name
p21 (RAC1) activated kinase 6provided by MGI
Primary source
MGI:MGI:2679420
See related
Ensembl:ENSMUSG00000074923 AllianceGenome:MGI:2679420
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4732456M09
Summary
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within learning or memory; locomotory behavior; and neuron projection morphogenesis. Predicted to be located in cell junction; fibrillar center; and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in central nervous system; retina; submandibular gland primordium; and tooth. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma. Orthologous to several human genes including BUB1B-PAK6 (BUB1B-PAK6 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 13.2), CNS E18 (RPKM 12.7) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E5; 2 59.41 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (118493531..118528501)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (118663045..118698020)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9527 Neighboring gene eukaryotic translation initiation factor 5A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8791 Neighboring gene BUB1B, mitotic checkpoint serine/threonine kinase Neighboring gene STARR-seq mESC enhancer starr_05463 Neighboring gene STARR-seq mESC enhancer starr_05464 Neighboring gene STARR-seq mESC enhancer starr_05465 Neighboring gene STARR-seq mESC enhancer starr_05466 Neighboring gene STARR-seq mESC enhancer starr_05467 Neighboring gene STARR-positive B cell enhancer ABC_E5965 Neighboring gene ankyrin repeat domain 63 Neighboring gene phospholipase C, beta 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:118554101-118554254

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential sensitivity of Pak5, Pak6, and Pak5/Pak6 double-knockout mice to the stimulant effects of amphetamine and exercise-induced alterations in body weight. Furnari MA, et al. Nutr Neurosci, 2014 Apr. PMID 23710594, Free PMC Article
  2. Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice. Furnari MA, et al. PLoS One, 2013. PMID 23593460, Free PMC Article
  3. Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion. Nekrasova T, et al. Dev Biol, 2008 Oct 1. PMID 18675265
  4. Targeted disruption of the gene for the PAK5 kinase in mice. Li X, et al. Mol Cell Biol, 2003 Oct. PMID 14517284, Free PMC Article
  5. Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain. Civiero L, et al. J Neurochem, 2015 Dec. PMID 26375402, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. p21-activated kinase 6 (PAK6) as a novel interactor of leucine-rich repeat kinase 2 (LRRK2), a kinase involved in Parkinson's disease
    Title: Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.
  2. data suggest that PAK-6 p21-activated kinase plays a role in weight gain unrelated to exercise and caloric intake
    Title: Differential sensitivity of Pak5, Pak6, and Pak5/Pak6 double-knockout mice to the stimulant effects of amphetamine and exercise-induced alterations in body weight.
  3. functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice
    Title: Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice.
  4. Our results indicate that Pak5 and Pak6 together are not required for viability, but are required for a normal level of locomotion and activity as well as for learning and memory.
    Title: Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within learning IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within locomotory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within memory IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neuron projection arborization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron projection extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
 PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase PAK 6
Names
PAK-6
p21 protein (Cdc42/Rac)-activated kinase 6
p21-activated kinase 6
NP_001028426.2
NP_001139326.1
NP_001411690.1
NP_001411691.1
XP_011237721.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033254.4 → NP_001028426.2  serine/threonine-protein kinase PAK 6

    See identical proteins and their annotated locations for NP_001028426.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants encode the same protein.
    Source sequence(s)
    AL845470
    Consensus CDS
    CCDS16580.1
    UniProtKB/Swiss-Prot
    Q3TY26, Q3ULB5
    UniProtKB/TrEMBL
    B2RWY1
    Related
    ENSMUSP00000097153.4, ENSMUST00000099557.10
    Conserved Domains (2) summary
    cd06659
    Location:386 → 682
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 63
    PBD; P21-Rho-binding domain

  2. NM_001145854.2 → NP_001139326.1  serine/threonine-protein kinase PAK 6

    See identical proteins and their annotated locations for NP_001139326.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AL845470
    Consensus CDS
    CCDS16580.1
    UniProtKB/Swiss-Prot
    Q3TY26, Q3ULB5
    UniProtKB/TrEMBL
    B2RWY1
    Related
    ENSMUSP00000106477.2, ENSMUST00000110853.8
    Conserved Domains (2) summary
    cd06659
    Location:386 → 682
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 63
    PBD; P21-Rho-binding domain

  3. NM_001424761.1 → NP_001411690.1  serine/threonine-protein kinase PAK 6

    Status: VALIDATED

    Source sequence(s)
    AL845470
    UniProtKB/Swiss-Prot
    Q3TY26, Q3ULB5

  4. NM_001424762.1 → NP_001411691.1  serine/threonine-protein kinase PAK 6

    Status: VALIDATED

    Source sequence(s)
    AL845470
    UniProtKB/Swiss-Prot
    Q3TY26, Q3ULB5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    118493531..118528501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239419.1 → XP_011237721.1  serine/threonine-protein kinase PAK 6 isoform X1

    See identical proteins and their annotated locations for XP_011237721.1

    UniProtKB/Swiss-Prot
    Q3TY26, Q3ULB5
    UniProtKB/TrEMBL
    B2RWY1
    Conserved Domains (2) summary
    cd06659
    Location:386 → 682
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 63
    PBD; P21-Rho-binding domain

RNA

  1. XR_866265.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3ULB5.1 GenPept UniProtKB/Swiss-Prot:Q3ULB5

Gene LinkOut

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