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Tfcp2 transcription factor CP2 [ Mus musculus (house mouse) ]

Gene ID: 21422, updated on 5-Mar-2024

Summary

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Official Symbol
Tfcp2provided by MGI
Official Full Name
transcription factor CP2provided by MGI
Primary source
MGI:MGI:98509
See related
Ensembl:ENSMUSG00000009733 AllianceGenome:MGI:98509
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CP2; LSF; CP-2; LBP1; UBP-1; LBP-1c; LBP-1d; Tcfcp2; D230015P20Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; early conceptus; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human TFCP2 (transcription factor CP2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 6.2), CNS E11.5 (RPKM 6.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tfcp2 in Genome Data Viewer
Location:
15 F1; 15 56.33 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100395083..100449896, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100497781..100552014, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5330439K02 gene Neighboring gene STARR-seq mESC enhancer starr_39751 Neighboring gene LETM1 domain containing 1 Neighboring gene cysteine-serine-rich nuclear protein 2 Neighboring gene STARR-seq mESC enhancer starr_39756 Neighboring gene STARR-positive B cell enhancer ABC_E7419 Neighboring gene STARR-seq mESC enhancer starr_39757 Neighboring gene STARR-positive B cell enhancer ABC_E4150 Neighboring gene POU domain, class 6, transcription factor 1 Neighboring gene RIKEN cDNA C330013E15 gene Neighboring gene STARR-positive B cell enhancer ABC_E610

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TFCP2, a binding protein of ATF3, promotes the progression of glioma by activating the synthesis of serine. Luo X, et al. Exp Cell Res, 2022 Jul 1. PMID 35421367
  2. Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model. Rajasekaran D, et al. Oncotarget, 2015 Sep 22. PMID 26313006, Free PMC Article
  3. Control of transferrin expression by β-amyloid through the CP2 transcription factor. Jang SM, et al. FEBS J, 2010 Oct. PMID 20796026
  4. Mbd2-CP2c loop drives adult-type globin gene expression and definitive erythropoiesis. Kim MY, et al. Nucleic Acids Res, 2018 Jun 1. PMID 29547954, Free PMC Article
  5. Reciprocal localization of transcription factors YY1 and CP2c in spermatogonial stem cells and their putative roles during spermatogenesis. Kim JS, et al. Acta Histochem, 2016 Sep. PMID 27612612

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TFCP2, a binding protein of ATF3, promotes the progression of glioma by activating the synthesis of serine.
    Title: TFCP2, a binding protein of ATF3, promotes the progression of glioma by activating the synthesis of serine.
  2. Mbd2-CP2c functional loop drives adult-type globin gene expression and erythroid differentiation of erythroid cells.
    Title: Mbd2-CP2c loop drives adult-type globin gene expression and definitive erythropoiesis.
  3. The transcription factor CP2 upregulated miR-144 expression, which partially contributed to the suppression of COX-2 in mGCs.
    Title: MicroRNA-144 is regulated by CP2 and decreases COX-2 expression and PGE2 production in mouse ovarian granulosa cells.
  4. that yin yang 1 strongly localizes in the spermatogonial stem cells and co-localizes heterogeneously with CP2c to permit spermatogenesis
    Title: Reciprocal localization of transcription factors YY1 and CP2c in spermatogonial stem cells and their putative roles during spermatogenesis.
  5. Small molecule inhibitors of Late SV40 Factor abrogate hepatocellular carcinoma by inducing mitotic arrest and apoptosis.
    Title: Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model.
  6. Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma
    Title: Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma.
  7. present study shows that a transcription factor previously unrelated with epithelial-mesenchymal transition (EMT), TFCP2c/LSF/LBP-1c, was translocated to the nucleus and bound to the fibronectin promoter upon EMT induction by Snail1
    Title: TFCP2c/LSF/LBP-1c is required for Snail1-induced fibronectin gene expression.
  8. the binding of Pin1 at the Thr-329-Pro-330 motif in LSF permits isomerization by Pin1 of the peptide bonds at the nearby phosphorylated SP motifs (Ser-291 and Ser-309) to the trans configuration, thereby facilitating their dephosphorylation.
    Title: Prolyl isomerase Pin1 regulates transcription factor LSF (TFCP2) by facilitating dephosphorylation at two serine-proline motifs.
  9. CP2 contributes to the pathogenesis of Alzheimer's disease by inducing transferrin expression via up-regulating its transcription.
    Title: Control of transferrin expression by β-amyloid through the CP2 transcription factor.
  10. Results identify LSF as only the second known target (in addition to pRb) of cyclin C/CDK2 activity during progression from quiescence to early G(1).
    Title: Phosphorylation by cyclin C/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of LSF during G1 progression.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
alpha-globin transcription factor CP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289603.1 → NP_001276532.1  alpha-globin transcription factor CP2 isoform 2

    See identical proteins and their annotated locations for NP_001276532.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC123724, AC139571
    Consensus CDS
    CCDS88846.1
    UniProtKB/TrEMBL
    A0A2R8VKI7
    Related
    ENSMUSP00000009877.8, ENSMUST00000009877.8
    Conserved Domains (2) summary
    pfam04516
    Location:52 → 257
    CP2; CP2 transcription factor
    cl15755
    Location:329 → 393
    SAM_superfamily; SAM (Sterile alpha motif )

  2. NM_001355497.1 → NP_001342426.1  alpha-globin transcription factor CP2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123724, AC139571
    UniProtKB/TrEMBL
    A0A2R8VKI7
    Conserved Domains (2) summary
    cd09589
    Location:329 → 395
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:52 → 257
    CP2; CP2 transcription factor

  3. NM_033476.3 → NP_258437.1  alpha-globin transcription factor CP2 isoform 1

    See identical proteins and their annotated locations for NP_258437.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC139571, AK146503
    Consensus CDS
    CCDS27840.1
    UniProtKB/Swiss-Prot
    Q3UGJ4, Q8VC13, Q9ERA0
    UniProtKB/TrEMBL
    A0A2R8VKI7
    Related
    ENSMUSP00000155683.2, ENSMUST00000229696.2
    Conserved Domains (2) summary
    cd09589
    Location:329 → 395
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:52 → 259
    CP2; CP2 transcription factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    100395083..100449896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316538.3 → XP_017172027.1  alpha-globin transcription factor CP2 isoform X2

    UniProtKB/TrEMBL
    A0A2R8VKI7
    Conserved Domains (2) summary
    cd09589
    Location:329 → 395
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:52 → 257
    CP2; CP2 transcription factor

  2. XM_017316537.2 → XP_017172026.1  alpha-globin transcription factor CP2 isoform X1

    UniProtKB/TrEMBL
    A0A2R8VKI7
    Conserved Domains (2) summary
    cd09589
    Location:329 → 395
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:52 → 257
    CP2; CP2 transcription factor

  3. XM_017316539.1 → XP_017172028.1  alpha-globin transcription factor CP2 isoform X1

    UniProtKB/TrEMBL
    A0A2R8VKI7
    Conserved Domains (2) summary
    cd09589
    Location:329 → 395
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:52 → 257
    CP2; CP2 transcription factor

  4. XM_036159310.1 → XP_036015203.1  alpha-globin transcription factor CP2 isoform X6

    Conserved Domains (2) summary
    cd09589
    Location:132 → 198
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:6 → 62
    CP2; CP2 transcription factor

  5. XM_030248456.2 → XP_030104316.1  alpha-globin transcription factor CP2 isoform X6

    Conserved Domains (2) summary
    cd09589
    Location:132 → 198
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:6 → 62
    CP2; CP2 transcription factor

  6. XM_030248455.2 → XP_030104315.1  alpha-globin transcription factor CP2 isoform X6

    Conserved Domains (2) summary
    cd09589
    Location:132 → 198
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:6 → 62
    CP2; CP2 transcription factor

  7. XM_036159311.1 → XP_036015204.1  alpha-globin transcription factor CP2 isoform X6

    Conserved Domains (2) summary
    cd09589
    Location:132 → 198
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:6 → 62
    CP2; CP2 transcription factor

  8. XM_017316541.2 → XP_017172030.1  alpha-globin transcription factor CP2 isoform X5

    Conserved Domains (2) summary
    cd09589
    Location:174 → 240
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:15 → 102
    CP2; CP2 transcription factor

  9. XM_006520738.3 → XP_006520801.2  alpha-globin transcription factor CP2 isoform X3

    UniProtKB/TrEMBL
    A0A2R8VKI7
    Conserved Domains (2) summary
    cd09589
    Location:329 → 395
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:52 → 257
    CP2; CP2 transcription factor

  10. XM_036159309.1 → XP_036015202.1  alpha-globin transcription factor CP2 isoform X4

    UniProtKB/Swiss-Prot
    Q3UGJ4, Q8VC13, Q9ERA0
    UniProtKB/TrEMBL
    A0A2R8VKI7
    Related
    ENSMUSP00000155581.2, ENSMUST00000229581.2
    Conserved Domains (2) summary
    cd09589
    Location:329 → 395
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:52 → 259
    CP2; CP2 transcription factor

  11. XM_036159312.1 → XP_036015205.1  alpha-globin transcription factor CP2 isoform X8

    UniProtKB/TrEMBL
    Q3URS4
    Conserved Domains (2) summary
    cd09589
    Location:132 → 198
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:6 → 62
    CP2; CP2 transcription factor

  12. XM_030248457.2 → XP_030104317.1  alpha-globin transcription factor CP2 isoform X7

    UniProtKB/TrEMBL
    Q3URS4
    Conserved Domains (2) summary
    cd09589
    Location:132 → 198
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:6 → 60
    CP2; CP2 transcription factor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERA0.1 GenPept UniProtKB/Swiss-Prot:Q9ERA0

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