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Dnajc16 DnaJ heat shock protein family (Hsp40) member C16 [ Mus musculus (house mouse) ]

Gene ID: 214063, updated on 5-Mar-2024

Summary

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Official Symbol
Dnajc16provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C16provided by MGI
Primary source
MGI:MGI:2442146
See related
Ensembl:ENSMUSG00000040697 AllianceGenome:MGI:2442146
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ERdj8; mKIAA0962; D030060M24; 2900037O03Rik; 4732437J24Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human DNAJC16 (DnaJ heat shock protein family (Hsp40) member C16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 8.9), adrenal adult (RPKM 8.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D3; 4 74.75 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (141487498..141518255, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141761998..141790644, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34863 Neighboring gene STARR-seq mESC enhancer starr_11931 Neighboring gene agmatinase Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:141346676-141346859 Neighboring gene STARR-positive B cell enhancer ABC_E1042 Neighboring gene caspase 9 Neighboring gene chymotrypsin-like elastase family, member 2A Neighboring gene chymotrypsin C Neighboring gene chymotrypsin C, opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
  2. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of autophagosome size ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily C member 16
Names
DnaJ (Hsp40) homolog, subfamily C, member 16
ER-resident protein ERdj8
endoplasmic reticulum DNA J domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172338.2 → NP_758841.1  dnaJ homolog subfamily C member 16 precursor

    See identical proteins and their annotated locations for NP_758841.1

    Status: PROVISIONAL

    Source sequence(s)
    AL928577
    Consensus CDS
    CCDS18882.1
    UniProtKB/Swiss-Prot
    Q80TN4, Q811G1, Q8BHI2
    Related
    ENSMUSP00000048714.5, ENSMUST00000038014.11
    Conserved Domains (2) summary
    COG0484
    Location:29 → 135
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    cd02963
    Location:134 → 243
    TRX_DnaJ; TRX domain, DnaJ domain containing protein family; composed of uncharacterized proteins of about 500-800 amino acids, containing an N-terminal DnaJ domain followed by one redox active TRX domain. DnaJ is a member of the 40 kDa heat-shock protein (Hsp40) ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    141487498..141518255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163946.1 → XP_036019839.1  dnaJ homolog subfamily C member 16 isoform X1

    UniProtKB/Swiss-Prot
    Q80TN4, Q811G1, Q8BHI2
    Conserved Domains (2) summary
    COG0484
    Location:29 → 135
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    cd02963
    Location:134 → 243
    TRX_DnaJ; TRX domain, DnaJ domain containing protein family; composed of uncharacterized proteins of about 500-800 amino acids, containing an N-terminal DnaJ domain followed by one redox active TRX domain. DnaJ is a member of the 40 kDa heat-shock protein (Hsp40) ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TN4.2 GenPept UniProtKB/Swiss-Prot:Q80TN4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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