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Tcf12 transcription factor 12 [ Mus musculus (house mouse) ]

Gene ID: 21406, updated on 21-Apr-2024

Summary

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Official Symbol
Tcf12provided by MGI
Official Full Name
transcription factor 12provided by MGI
Primary source
MGI:MGI:101877
See related
Ensembl:ENSMUSG00000032228 AllianceGenome:MGI:101877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HEB; ME1; REB; ALF1; HTF4; HTF-4; HEBAlt; bHLHb20; A130037E08Rik
Summary
Enables E-box binding activity and protein heterodimerization activity. Involved in positive regulation of neuron differentiation. Acts upstream of or within positive regulation of gene expression and positive regulation of transcription, DNA-templated. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in craniosynostosis. Orthologous to human TCF12 (transcription factor 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 41.6), limb E14.5 (RPKM 34.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 D; 9 39.85 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (71751534..72019611, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (71844252..72111893, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:71454614-71454767 Neighboring gene STARR-seq mESC enhancer starr_24576 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:71471793-71471976 Neighboring gene STARR-seq mESC enhancer starr_24577 Neighboring gene STARR-positive B cell enhancer mm9_chr9:71493898-71494198 Neighboring gene dynein light chain 1, cytoplasmic-like Neighboring gene cingulin-like 1 Neighboring gene predicted gene, 51713 Neighboring gene STARR-seq mESC enhancer starr_24580 Neighboring gene STARR-seq mESC enhancer starr_24581 Neighboring gene STARR-seq mESC enhancer starr_24582 Neighboring gene STARR-seq mESC enhancer starr_24583 Neighboring gene STARR-positive B cell enhancer ABC_E2904 Neighboring gene splicing factor, arginine/serine-rich 7 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr9:71799166-71799467 Neighboring gene STARR-positive B cell enhancer mm9_chr9:71823828-71824128 Neighboring gene ribosomal protein L15, pseudogene 2 Neighboring gene predicted gene, 25045 Neighboring gene ribosomal protein L7A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon.
    Title: Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon.
  2. Tcf12 and NeuroD1 cooperatively drive neuronal migration during cortical development.
    Title: Tcf12 and NeuroD1 cooperatively drive neuronal migration during cortical development.
  3. MACF1 promotes osteoblast differentiation by sequestering repressors in cytoplasm.
    Title: MACF1 promotes osteoblast differentiation by sequestering repressors in cytoplasm.
  4. Embryonic requirements for Tcf12 in the development of the mouse coronal suture.
    Title: Embryonic requirements for Tcf12 in the development of the mouse coronal suture.
  5. circHIPK3 regulates proliferation and differentiation of myoblast through the miR-7/TCF12 pathway.
    Title: circHIPK3 regulates proliferation and differentiation of myoblast through the miR-7/TCF12 pathway.
  6. The Concerted Action of E2-2 and HEB Is Critical for Early Lymphoid Specification.
    Title: The Concerted Action of E2-2 and HEB Is Critical for Early Lymphoid Specification.
  7. Transcriptome and ChIP-seq analyses revealed that E protein directly regulates a large proportion of the genes that are specific to effector Treg cell activation, and importantly, most of the up-regulated genes in E protein-deficient Treg cells are also TCR dependent
    Title: E-protein regulatory network links TCR signaling to effector Treg cell differentiation.
  8. TCF-1 both enhances HEB protein stability and functionally cooperates with HEB in defining the epigenetic and transcriptional status of CD4(+)CD8(+) thymocytes
    Title: TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4(+)CD8(+) thymocytes.
  9. HEB may be required for a proper regulation of Lpar1 expression in the embryonic neocortical neuroblast cells.
    Title: HeLa E-Box Binding Protein, HEB, Inhibits Promoter Activity of the Lysophosphatidic Acid Receptor Gene Lpar1 in Neocortical Neuroblast Cells.
  10. Mouse genetics further reveal requirements for Twist1 and Tcf12 in both the frontal and parietal bones for suture patency, and to maintain putative progenitors in the coronal region
    Title: Altered bone growth dynamics prefigure craniosynostosis in a zebrafish model of Saethre-Chotzen syndrome.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables E-box binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables HMG box domain binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
  
enables bHLH transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables cAMP response element binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to gonadotropin-releasing hormone ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcription factor 12
Names
DNA-binding protein HTF4
E-box-binding protein
TCF-12
class A helix-loop-helix transcription factor ME1
transcription factor HTF-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253862.1 → NP_001240791.1  transcription factor 12 isoform 2

    See identical proteins and their annotated locations for NP_001240791.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR and lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK133958, AK134037, AK134502, BQ127642
    Consensus CDS
    CCDS72272.1
    UniProtKB/TrEMBL
    V9GWU2
    Conserved Domains (1) summary
    cd18945
    Location:571 → 655
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

  2. NM_001253863.1 → NP_001240792.1  transcription factor 12 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a different 5' end and lacks several exon in the coding region, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AK133958, AK134502, AK135376, BQ127642, CJ164494
    Consensus CDS
    CCDS72271.1
    UniProtKB/TrEMBL
    Q3UZA4, V9GX46
    Related
    ENSMUSP00000138978.2, ENSMUST00000183918.8
    Conserved Domains (2) summary
    smart00353
    Location:437 → 490
    HLH; helix loop helix domain
    pfam09786
    Location:105 → 292
    CytochromB561_N; Cytochrome B561, N terminal

  3. NM_001253864.1 → NP_001240793.1  transcription factor 12 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has a different 5' end and lacks several exons in the coding region, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 4) is shorter and has a distinct N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AK133958, AK134502, AK135376, BQ127642, CJ164494
    UniProtKB/TrEMBL
    Q3UZA4
    Related
    ENSMUSP00000139334.2, ENSMUST00000184448.8
    Conserved Domains (1) summary
    smart00353
    Location:413 → 466
    HLH; helix loop helix domain

  4. NM_001253865.1 → NP_001240794.1  transcription factor 12 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks several exons in the coding region, compared to variant 1. The resulting protein (isoform 5) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK133958, AK134502, BQ127642, BY739497, X64840
    UniProtKB/TrEMBL
    Q8K1X3
    Conserved Domains (1) summary
    smart00353
    Location:364 → 417
    HLH; helix loop helix domain

  5. NM_011544.3 → NP_035674.2  transcription factor 12 isoform 1

    See identical proteins and their annotated locations for NP_035674.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AK133958, AK134502, AK143246, BQ127642, BY739497, X64840
    Consensus CDS
    CCDS23329.1
    UniProtKB/Swiss-Prot
    E9QPN4, Q61286
    UniProtKB/TrEMBL
    V9GWU2
    Related
    ENSMUSP00000139365.2, ENSMUST00000183404.8
    Conserved Domains (1) summary
    cd18945
    Location:595 → 679
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    71751534..72019611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154818.1 → XP_036010711.1  transcription factor 12 isoform X14

    UniProtKB/TrEMBL
    Q8K1X3
    Conserved Domains (1) summary
    cd18945
    Location:376 → 460
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

  2. XM_006510998.4 → XP_006511061.1  transcription factor 12 isoform X5

    UniProtKB/TrEMBL
    V9GWU2
    Conserved Domains (1) summary
    cd18945
    Location:570 → 654
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

  3. XM_006510999.4 → XP_006511062.1  transcription factor 12 isoform X6

    UniProtKB/TrEMBL
    V9GWU2
    Conserved Domains (1) summary
    cd18945
    Location:570 → 654
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

  4. XM_006510997.4 → XP_006511060.1  transcription factor 12 isoform X4

    See identical proteins and their annotated locations for XP_006511060.1

    UniProtKB/TrEMBL
    V9GWU2
    Related
    ENSMUSP00000034755.7, ENSMUST00000034755.13
    Conserved Domains (1) summary
    cd18945
    Location:571 → 655
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

  5. XM_006510995.4 → XP_006511058.1  transcription factor 12 isoform X2

    UniProtKB/TrEMBL
    V9GWU2
    Conserved Domains (1) summary
    cd18945
    Location:594 → 678
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

  6. XM_006510996.4 → XP_006511059.1  transcription factor 12 isoform X3

    UniProtKB/TrEMBL
    V9GWU2
    Conserved Domains (1) summary
    cd18945
    Location:594 → 678
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

  7. XM_030244212.2 → XP_030100072.1  transcription factor 12 isoform X9

    UniProtKB/TrEMBL
    V9GWU2
    Conserved Domains (1) summary
    cd18945
    Location:512 → 596
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

  8. XM_017313270.3 → XP_017168759.1  transcription factor 12 isoform X8

    UniProtKB/TrEMBL
    V9GWU2
    Conserved Domains (1) summary
    cd18945
    Location:513 → 597
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

  9. XM_006511000.5 → XP_006511063.1  transcription factor 12 isoform X7

    UniProtKB/TrEMBL
    V9GWU2
    Conserved Domains (1) summary
    cd18945
    Location:537 → 621
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

  10. XM_006510994.5 → XP_006511057.1  transcription factor 12 isoform X1

    See identical proteins and their annotated locations for XP_006511057.1

    UniProtKB/Swiss-Prot
    E9QPN4, Q61286
    UniProtKB/TrEMBL
    V9GWU2
    Conserved Domains (1) summary
    cd18945
    Location:595 → 679
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

  11. XM_030244214.1 → XP_030100074.1  transcription factor 12 isoform X12

    UniProtKB/TrEMBL
    Q3UZA4
    Conserved Domains (1) summary
    cd18945
    Location:434 → 518
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

  12. XM_006511002.2 → XP_006511065.1  transcription factor 12 isoform X13

    UniProtKB/TrEMBL
    Q3UZA4
    Conserved Domains (1) summary
    cd18945
    Location:434 → 518
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

  13. XM_030244213.1 → XP_030100073.1  transcription factor 12 isoform X10

    UniProtKB/TrEMBL
    Q3UZA4
    Conserved Domains (1) summary
    cd18945
    Location:458 → 542
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

  14. XM_036154817.1 → XP_036010710.1  transcription factor 12 isoform X11

    UniProtKB/TrEMBL
    Q3UZA4
    Conserved Domains (1) summary
    cd18945
    Location:458 → 542
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61286.2 GenPept UniProtKB/Swiss-Prot:Q61286

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