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Tcea3 transcription elongation factor A (SII), 3 [ Mus musculus (house mouse) ]

Gene ID: 21401, updated on 21-Apr-2024

Summary

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Official Symbol
Tcea3provided by MGI
Official Full Name
transcription elongation factor A (SII), 3provided by MGI
Primary source
MGI:MGI:1196908
See related
Ensembl:ENSMUSG00000001604 AllianceGenome:MGI:1196908
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S-II; SII-K1
Summary
Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including apical ectodermal ridge; early conceptus; genitourinary system; retina; and tongue. Orthologous to human TCEA3 (transcription elongation factor A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 16.7), heart adult (RPKM 13.2) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D3; 4 68.34 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135975253..136002214)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136247936..136274903)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135727983-135728166 Neighboring gene STARR-positive B cell enhancer ABC_E3530 Neighboring gene STARR-seq mESC enhancer starr_11747 Neighboring gene STARR-positive B cell enhancer ABC_E6237 Neighboring gene STARR-positive B cell enhancer ABC_E427 Neighboring gene E2F transcription factor 2 Neighboring gene STARR-seq mESC enhancer starr_11748 Neighboring gene STARR-seq mESC enhancer starr_11749 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 Neighboring gene STARR-seq mESC enhancer starr_11750 Neighboring gene STARR-positive B cell enhancer ABC_E9604 Neighboring gene STARR-positive B cell enhancer ABC_E4689 Neighboring gene zinc finger protein 46 Neighboring gene STARR-seq mESC enhancer starr_11754 Neighboring gene STARR-seq mESC enhancer starr_11755 Neighboring gene heterogeneous nuclear ribonucleoprotein R Neighboring gene predicted gene, 54262

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The transcription elongation factor TCEA3 promotes the activity of the myogenic regulatory factors. Kazim N, et al. PLoS One, 2019. PMID 31158246, Free PMC Article
  2. Tcea3 regulates the vascular differentiation potential of mouse embryonic stem cells. Cha Y, et al. Gene Expr, 2013. PMID 24397209, Free PMC Article
  3. Reduced expression of Sytl 1 and Ccdc21 and impaired induction of Mt I by oxidative stress in SII-K1 knockout mice. Tano K, et al. Drug Discov Ther, 2010 Oct. PMID 22491241
  4. Molecular cloning of cDNA and tissue-specific expression of the gene for SII-K1, a novel transcription elongation factor SII. Taira Y, et al. Genes Cells, 1998 May. PMID 9685180
  5. Transcription factor genes and the developing eye: a genetic perspective. Freund C, et al. Hum Mol Genet, 1996. PMID 8875254

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. which is located in the cytoplasm and also promotes cell differentiation. Collectively, our results indicate that TCEA3 promotes cell differentiation by interacting with ANXA1 and affecting transforming growth factor-b signaling pathways
    Title: TCEA3 promotes differentiation of C2C12 cells via an Annexin A1-mediated transforming growth factor-β signaling pathway.
  2. TCEA3 is a required co-factor for myogenic regulatory factors driven gene expression during myogenesis.
    Title: The transcription elongation factor TCEA3 promotes the activity of the myogenic regulatory factors.
  3. Vascular endothelial growth factor A and VEGFC, major transcription factors that regulate vasculogenesis, are activated in Tcea3 knocked down mESCs
    Title: Tcea3 regulates the vascular differentiation potential of mouse embryonic stem cells.
  4. Tcea3 critically regulates pluripotent differentiation of mouse embryonic stem cells as a molecular rheostat of Lefty1-Nodal-Smad2 signaling.
    Title: Transcription elongation factor Tcea3 regulates the pluripotent differentiation potential of mouse embryonic stem cells via the Lefty1-Nodal-Smad2 pathway.
  5. These results suggest that S-II is involved in transcription of the Bcl-x and beta(major)-globin gene during erythroblast differentiation, by relieving transcription arrest or affecting histone modification on chromatin template.
    Title: Transcription arrest relief by S-II/TFIIS during gene expression in erythroblast differentiation.
  6. S-II is required for definitive hematopoiesis.
    Title: Transcription elongation factor S-II is required for definitive hematopoiesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcription elongation factor A protein 3
Names
tissue-specific transcription factor S-II
transcription elongation factor S-II protein 3
transcription elongation factor TFIIS.h

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011542.2 → NP_035672.1  transcription elongation factor A protein 3

    See identical proteins and their annotated locations for NP_035672.1

    Status: VALIDATED

    Source sequence(s)
    AK002319, AK007437
    Consensus CDS
    CCDS18803.1
    UniProtKB/Swiss-Prot
    A2AW46, O88710, P23881, Q9CTZ8, Q9DCZ5
    UniProtKB/TrEMBL
    A8CA96
    Related
    ENSMUSP00000099592.5, ENSMUST00000102533.11
    Conserved Domains (4) summary
    smart00510
    Location:184 → 285
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    cd00183
    Location:4 → 80
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
    cd13749
    Location:300 → 346
    Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS
    TIGR01385
    Location:5 → 347
    TFSII; transcription elongation factor S-II

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    135975253..136002214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538710.5 → XP_006538773.1  transcription elongation factor A protein 3 isoform X1

    UniProtKB/TrEMBL
    A8CA96
    Conserved Domains (1) summary
    TIGR01385
    Location:5 → 385
    TFSII; transcription elongation factor S-II

  2. XM_006538712.5 → XP_006538775.1  transcription elongation factor A protein 3 isoform X3

    UniProtKB/TrEMBL
    A8CA96
    Conserved Domains (1) summary
    TIGR01385
    Location:5 → 361
    TFSII; transcription elongation factor S-II

  3. XM_006538711.5 → XP_006538774.1  transcription elongation factor A protein 3 isoform X2

    UniProtKB/TrEMBL
    A8CA96
    Conserved Domains (1) summary
    TIGR01385
    Location:5 → 371
    TFSII; transcription elongation factor S-II
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23881.3 GenPept UniProtKB/Swiss-Prot:P23881

Gene LinkOut

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