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Ccdc186 coiled-coil domain containing 186 [ Mus musculus (house mouse) ]

Gene ID: 213993, updated on 5-Mar-2024

Summary

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Official Symbol
Ccdc186provided by MGI
Official Full Name
coiled-coil domain containing 186provided by MGI
Primary source
MGI:MGI:2445022
See related
Ensembl:ENSMUSG00000035173 AllianceGenome:MGI:2445022
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Otg1; 1810028B20Rik; A630007B06Rik
Summary
Predicted to enable small GTPase binding activity. Acts upstream of or within insulin secretion involved in cellular response to glucose stimulus; response to bacterium; and vesicle cytoskeletal trafficking. Located in Golgi apparatus. Is expressed in brain. Orthologous to human CCDC186 (coiled-coil domain containing 186). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 5.0), CNS E14 (RPKM 4.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ccdc186 in Genome Data Viewer
Location:
19 D2; 19 51.99 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (56775917..56810631, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (56787485..56822199, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene adrenergic receptor, beta 1 Neighboring gene predicted gene, 32718 Neighboring gene rp1 MIF pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5712 Neighboring gene tudor domain containing 1 Neighboring gene von Willebrand factor A domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disruption of the Golgi protein Otg1 gene causes defective hormone secretion and aberrant glucose homeostasis in mice. Wang G, et al. Cell Biosci, 2016. PMID 27293546, Free PMC Article
  2. Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. Oduru S, et al. BMC Genomics, 2003 Jun 3. PMID 12783626, Free PMC Article
  3. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152
  4. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transposon induced (1)  1 citation
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in vesicle cytoskeletal trafficking IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vesicle cytoskeletal trafficking IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 186
Names
oocyte-testis gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_170757.2 → NP_739563.1  coiled-coil domain-containing protein 186

    See identical proteins and their annotated locations for NP_739563.1

    Status: VALIDATED

    Source sequence(s)
    AC158549
    Consensus CDS
    CCDS29921.1
    UniProtKB/Swiss-Prot
    Q6P3D6, Q8C9S4, Q8CJC0
    Related
    ENSMUSP00000113457.2, ENSMUST00000118592.8
    Conserved Domains (1) summary
    pfam09728
    Location:315 → 645
    Taxilin; Myosin-like coiled-coil protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    56775917..56810631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526852.2 → XP_006526915.1  coiled-coil domain-containing protein 186 isoform X1

    Conserved Domains (2) summary
    COG1196
    Location:159 → 533
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:42 → 324
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C9S4.2 GenPept UniProtKB/Swiss-Prot:Q8C9S4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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