U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tcea1 transcription elongation factor A (SII) 1 [ Mus musculus (house mouse) ]

Gene ID: 21399, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Tcea1provided by MGI
Official Full Name
transcription elongation factor A (SII) 1provided by MGI
Primary source
MGI:MGI:1196624
See related
Ensembl:ENSMUSG00000033813 AllianceGenome:MGI:1196624
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S-II
Summary
Predicted to enable DNA binding activity and zinc ion binding activity. Acts upstream of or within erythrocyte differentiation and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; lung; and spleen. Orthologous to human TCEA1 (transcription elongation factor A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 29.3), liver E14 (RPKM 24.7) and 24 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1 A1; 1 1.79 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (4927917..4968132)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (4857694..4897909)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene lysophospholipase 1 Neighboring gene STARR-seq mESC enhancer starr_00043 Neighboring gene predicted gene, 57794 Neighboring gene high mobility group box 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00045 Neighboring gene regulator of G-protein signaling 20 Neighboring gene STARR-seq mESC enhancer starr_00046 Neighboring gene STARR-seq mESC enhancer starr_00048 Neighboring gene predicted gene 16041 Neighboring gene STARR-seq mESC enhancer starr_00049 Neighboring gene STARR-seq mESC enhancer starr_00050 Neighboring gene heat shock protein 1 (chaperonin) pseudogene 17

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. TCEA1 regulates the proliferative potential of mouse myeloid cells. Yang T, et al. Exp Cell Res, 2018 Sep 15. PMID 30009791, Free PMC Article
  2. Molecular cloning of cDNA and tissue-specific expression of the gene for SII-K1, a novel transcription elongation factor SII. Taira Y, et al. Genes Cells, 1998 May. PMID 9685180
  3. Molecular cloning and characterization of cDNA for eukaryotic transcription factor S-II. Hirashima S, et al. J Biol Chem, 1988 Mar 15. PMID 3346229
  4. Transcription elongation factor Tcea3 regulates the pluripotent differentiation potential of mouse embryonic stem cells via the Lefty1-Nodal-Smad2 pathway. Park KS, et al. Stem Cells, 2013 Feb. PMID 23169579, Free PMC Article
  5. A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII. Yeh CH, et al. Gene, 1994 Jun 10. PMID 8206389

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC103154

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transcription elongation factor A protein 1
Names
transcription elongation factor S-II protein 1
transcription elongation factor TFIIS.o

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159750.1 → NP_001153222.1  transcription elongation factor A protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and lacks an internal aa compared to isoform 1.
    Source sequence(s)
    AK136035, BC083127, CD545750, CJ059479
    UniProtKB/TrEMBL
    Q3UPE0
    Conserved Domains (1) summary
    cl02637
    Location:4 → 300
    TFIIS_M; Transcription factor S-II (TFIIS), central domain

  2. NM_001159751.1 → NP_001153223.1  transcription elongation factor A protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK131928, AK136035, BC083127
    Consensus CDS
    CCDS48212.1
    UniProtKB/TrEMBL
    E9PYD5, Q3UPE0
    Related
    ENSMUSP00000129157.3, ENSMUST00000165720.3
    Conserved Domains (4) summary
    cd00183
    Location:35 → 89
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
    cd13749
    Location:265 → 311
    Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS
    TIGR01385
    Location:33 → 312
    TFSII; transcription elongation factor S-II
    pfam07500
    Location:149 → 256
    TFIIS_M; Transcription factor S-II (TFIIS), central domain

  3. NM_011541.4 → NP_035671.1  transcription elongation factor A protein 1 isoform 2

    See identical proteins and their annotated locations for NP_035671.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK136035, BC083127, CJ059479
    Consensus CDS
    CCDS35505.1
    UniProtKB/Swiss-Prot
    P10711, P10712, P23713
    UniProtKB/TrEMBL
    Q3UPE0, Q3UWX7
    Related
    ENSMUSP00000080266.8, ENSMUST00000081551.14
    Conserved Domains (1) summary
    cl02637
    Location:4 → 301
    TFIIS_M; Transcription factor S-II (TFIIS), central domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    4927917..4968132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10711.2 GenPept UniProtKB/Swiss-Prot:P10711

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous