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Tbxas1 thromboxane A synthase 1, platelet [ Mus musculus (house mouse) ]

Gene ID: 21391, updated on 3-Apr-2024

Summary

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Official Symbol
Tbxas1provided by MGI
Official Full Name
thromboxane A synthase 1, plateletprovided by MGI
Primary source
MGI:MGI:98497
See related
Ensembl:ENSMUSG00000029925 AllianceGenome:MGI:98497
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TS; TXS; CYP5; THAS; TXAS; CYP5A1
Summary
Enables thromboxane-A synthase activity. Predicted to be involved in cellular chloride ion homeostasis; positive regulation of vasoconstriction; and prostaglandin biosynthetic process. Predicted to act upstream of or within fatty acid biosynthetic process and prostaglandin metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including bone marrow; brain; liver; lung; and metanephros. Human ortholog(s) of this gene implicated in Ghosal hematodiaphyseal syndrome; cerebral infarction; and platelet-type bleeding disorder 14. Orthologous to human TBXAS1 (thromboxane A synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 4.2), spleen adult (RPKM 3.2) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B1; 6 17.85 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (38817897..39061524)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (38864159..39084590)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr6:38676623-38676923 Neighboring gene STARR-positive B cell enhancer mm9_chr6:38677325-38677625 Neighboring gene RIKEN cDNA 4930502C15 gene Neighboring gene homeodomain interacting protein kinase 2 Neighboring gene predicted gene, 53285 Neighboring gene Hipk2R16 erythroid cis-regulatory module Neighboring gene predicted gene, 33767 Neighboring gene predicted gene, 57771 Neighboring gene predicted gene, 52859 Neighboring gene predicted gene, 23010 Neighboring gene RIKEN cDNA 1700025N23 gene Neighboring gene predicted gene, 46989 Neighboring gene RIKEN cDNA 4930599N23 gene Neighboring gene poly (ADP-ribose) polymerase family, member 12 Neighboring gene STARR-seq mESC enhancer starr_15629 Neighboring gene lysine (K)-specific demethylase 7A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TXAS-deleted mice exhibit normal thrombopoiesis, defective hemostasis, and resistance to arachidonate-induced death. Yu IS, et al. Blood, 2004 Jul 1. PMID 15010374
  2. Genomic organization, chromosomal localization, and expression of the murine thromboxane synthase gene. Zhang L, et al. Genomics, 1997 Nov 1. PMID 9367676
  3. Thromboxane A2 Synthase and Thromboxane Receptor Deletion Reduces Ischaemia/Reperfusion-Evoked Inflammation, Apoptosis, Autophagy and Pyroptosis. Chueh TH, et al. Thromb Haemost, 2020 Feb. PMID 31785598
  4. Genetic Depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor Signalling Prevents Microvascular Dysfunction in Ischaemia/Reperfusion Injury. Chiang CY, et al. Thromb Haemost, 2018 Nov. PMID 30300909
  5. Lack of Thromboxane Synthase Prevents Hypertension and Fetal Growth Restriction after High Salt Treatment during Pregnancy. Pai CH, et al. PLoS One, 2016. PMID 26974824, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thromboxane A2 Synthase and Thromboxane Receptor Deletion Reduces Ischaemia/Reperfusion-Evoked Inflammation, Apoptosis, Autophagy and Pyroptosis.
    Title: Thromboxane A2 Synthase and Thromboxane Receptor Deletion Reduces Ischaemia/Reperfusion-Evoked Inflammation, Apoptosis, Autophagy and Pyroptosis.
  2. this study shows that genetic depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor signaling prevents microvascular dysfunction in ischemia reperfusion injury
    Title: Genetic Depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor Signalling Prevents Microvascular Dysfunction in Ischaemia/Reperfusion Injury.
  3. the administration of salted drinking water (2.7% NaCl) to wild-type mice resulted in elevated placental TXA2 synthase (TXAS) and plasma thromboxane A2, but not prostacyclin, levels, which was also found in clinical preeclampsia placenta samples.
    Title: Lack of Thromboxane Synthase Prevents Hypertension and Fetal Growth Restriction after High Salt Treatment during Pregnancy.
  4. 12-HHT is produced by both TxAS-dependent and TxAS-independent pathways in vitro and in vi
    Title: Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand.
  5. TXAS mRNA expression was increased within the vascular wall in mouse models of atherosclerosis with advanced lesions.
    Title: Thromboxane synthase expression and thromboxane A2 production in the atherosclerotic lesion.
  6. thromboxane synthase, prostacyclin synthase and thromboxane receptor have roles in atherosclerotic lesions and correlate with plaque composition
    Title: Expression of thromboxane synthase, prostacyclin synthase and thromboxane receptor in atherosclerotic lesions: correlation with plaque composition.
  7. minimal level of protein kinase A activity is required for the steroidogenic effect of the TBXAS inhibitor and that inhibition of TBXAS activity or its expression increase the steroidogenic sensitivity of MA-10 mouse Leydig cells to cAMP stimulation
    Title: Inhibition of thromboxane a synthase activity enhances steroidogenesis and steroidogenic acute regulatory gene expression in MA-10 mouse Leydig cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables hydroperoxy icosatetraenoate dehydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables thromboxane-A synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thromboxane-A synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables thromboxane-A synthase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in icosanoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular chloride ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
  
involved_in prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within prostaglandin metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
thromboxane-A synthase
Names
TXA synthase
cytochrome P450 5A1
hydroperoxy icosatetraenoate dehydratase
thromboxane synthase
NP_001397404.1
NP_001397405.1
NP_001397406.1
NP_035669.3
XP_006505939.1
XP_006505942.1
XP_006505943.1
XP_006505944.1
XP_011239582.1
XP_017176988.1
XP_017176989.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410475.1 → NP_001397404.1  thromboxane-A synthase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125327, AC154016

  2. NM_001410476.1 → NP_001397405.1  thromboxane-A synthase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125327, AC154016

  3. NM_001410477.1 → NP_001397406.1  thromboxane-A synthase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC125327, AC154016

  4. NM_011539.4 → NP_035669.3  thromboxane-A synthase isoform 1

    See identical proteins and their annotated locations for NP_035669.3

    Status: VALIDATED

    Source sequence(s)
    AC125327, AC154016
    Consensus CDS
    CCDS20018.1
    UniProtKB/Swiss-Prot
    P36423, P97505
    UniProtKB/TrEMBL
    Q8K320
    Related
    ENSMUSP00000003017.7, ENSMUST00000003017.13
    Conserved Domains (1) summary
    pfam00067
    Location:47 → 528
    p450; Cytochrome P450

RNA

  1. NR_177077.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125327, AC154016

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    38817897..39061524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321499.3 → XP_017176988.1  thromboxane-A synthase isoform X1

    UniProtKB/Swiss-Prot
    P36423, P97505
    UniProtKB/TrEMBL
    Q8K320
    Conserved Domains (1) summary
    pfam00067
    Location:47 → 528
    p450; Cytochrome P450

  2. XM_017321500.3 → XP_017176989.1  thromboxane-A synthase isoform X1

    UniProtKB/Swiss-Prot
    P36423, P97505
    UniProtKB/TrEMBL
    Q8K320
    Conserved Domains (1) summary
    pfam00067
    Location:47 → 528
    p450; Cytochrome P450

  3. XM_011241280.4 → XP_011239582.1  thromboxane-A synthase isoform X1

    See identical proteins and their annotated locations for XP_011239582.1

    UniProtKB/Swiss-Prot
    P36423, P97505
    UniProtKB/TrEMBL
    Q8K320
    Conserved Domains (1) summary
    pfam00067
    Location:47 → 528
    p450; Cytochrome P450

  4. XM_006505881.4 → XP_006505944.1  thromboxane-A synthase isoform X7

    UniProtKB/TrEMBL
    Q3UTF0
    Conserved Domains (1) summary
    cl12078
    Location:47 → 378
    p450; Cytochrome P450

  5. XM_006505879.5 → XP_006505942.1  thromboxane-A synthase isoform X5

    UniProtKB/TrEMBL
    Q3UTF0
    Conserved Domains (1) summary
    cl12078
    Location:47 → 455
    p450; Cytochrome P450

  6. XM_006505876.4 → XP_006505939.1  thromboxane-A synthase isoform X2

    UniProtKB/TrEMBL
    Q8K320
    Conserved Domains (1) summary
    pfam00067
    Location:47 → 528
    p450; Cytochrome P450

  7. XM_006505880.5 → XP_006505943.1  thromboxane-A synthase isoform X6

    Conserved Domains (1) summary
    pfam00067
    Location:6 → 410
    p450; Cytochrome P450
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36423.2 GenPept UniProtKB/Swiss-Prot:P36423

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