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Arcn1 archain 1 [ Mus musculus (house mouse) ]

Gene ID: 213827, updated on 30-Apr-2024

Summary

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Official Symbol
Arcn1provided by MGI
Official Full Name
archain 1provided by MGI
Primary source
MGI:MGI:2387591
See related
Ensembl:ENSMUSG00000032096 AllianceGenome:MGI:2387591
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
nur17; 4632432M07Rik
Summary
Acts upstream of or within several processes, including Golgi vesicle transport; adult locomotory behavior; and cerebellar Purkinje cell layer maturation. Located in COPI-coated vesicle; Golgi apparatus; and endoplasmic reticulum. Is expressed in several structures, including genitourinary system. Orthologous to human ARCN1 (archain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 54.6), limb E14.5 (RPKM 40.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A5.2; 9 24.84 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44653440..44679105, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44742143..44767808, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene trehalase (brush-border membrane glycoprotein) Neighboring gene pleckstrin homology like domain, family B, member 1 Neighboring gene predicted gene, 24166 Neighboring gene STARR-positive B cell enhancer ABC_E9756 Neighboring gene intraflagellar transport 46 Neighboring gene transmembrane protein 25 Neighboring gene tetratricopeptide repeat domain 36

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Relevance of the COPI complex for Alzheimer's disease progression in vivo. Bettayeb K, et al. Proc Natl Acad Sci U S A, 2016 May 10. PMID 27114526, Free PMC Article
  2. Mutation in archain 1, a subunit of COPI coatomer complex, causes diluted coat color and Purkinje cell degeneration. Xu X, et al. PLoS Genet, 2010 May 20. PMID 20502676, Free PMC Article
  3. Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP. Hata S, et al. J Biol Chem, 2006 Apr 21. PMID 16476741
  4. Functional genetic analysis of mouse chromosome 11. Kile BT, et al. Nature, 2003 Sep 4. PMID 12955145
  5. The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4. Ahn Y, et al. Biochem J, 2008 Jun 1. PMID 18307411

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP
    Title: Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Chemically induced (ENU) (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC27546, MGC102316

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in Golgi localization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Golgi vesicle transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cerebellar Purkinje cell layer maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pigmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in COPI-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coatomer subunit delta
Names
delta-COP
delta-coat protein
pale coat neuro

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145985.4 → NP_666097.3  coatomer subunit delta

    See identical proteins and their annotated locations for NP_666097.3

    Status: PROVISIONAL

    Source sequence(s)
    BC033387
    Consensus CDS
    CCDS40602.1
    UniProtKB/Swiss-Prot
    Q5XJY5, Q91W48
    UniProtKB/TrEMBL
    Q3U4S9
    Related
    ENSMUSP00000034607.10, ENSMUST00000034607.10
    Conserved Domains (2) summary
    cd09254
    Location:272 → 508
    AP_delta-COPI_MHD; Mu homology domain (MHD) of adaptor protein (AP) coat protein I (COPI) delta subunit
    cd14830
    Location:4 → 133
    Delta_COP_N; delta subunit of the F-COPI complex, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44653440..44679105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XJY5.2 GenPept UniProtKB/Swiss-Prot:Q5XJY5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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