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Casd1 CAS1 domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 213819, updated on 11-Apr-2024

Summary

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Official Symbol
Casd1provided by MGI
Official Full Name
CAS1 domain containing 1provided by MGI
Primary source
MGI:MGI:2384865
See related
Ensembl:ENSMUSG00000015189 AllianceGenome:MGI:2384865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cas1; SOAT; Cast1
Summary
Predicted to enable N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Predicted to be integral component of Golgi membrane. Is expressed in several structures, including liver; lung; placenta; spleen; and yolk sac. Orthologous to human CASD1 (CAS1 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 14.8), CNS E18 (RPKM 14.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 A1; 6 1.81 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (4600911..4643355)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (4600911..4643355)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene chitobiase, di-N-acetyl- pseudogene Neighboring gene predicted gene, 33959 Neighboring gene predicted gene, 38761 Neighboring gene STARR-seq mESC enhancer starr_15017 Neighboring gene STARR-seq mESC enhancer starr_15018 Neighboring gene sarcoglycan, epsilon Neighboring gene STARR-seq mESC enhancer starr_15019

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Alterations in sialic-acid O-acetylation glycoforms during murine erythrocyte development. Mahajan VS, et al. Glycobiology, 2019 Mar 1. PMID 30597004, Free PMC Article
  2. A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1. Wang X, et al. J Neurosci, 2009 Oct 7. PMID 19812333, Free PMC Article
  3. Identification of a large novel imprinted gene cluster on mouse proximal chromosome 6. Ono R, et al. Genome Res, 2003 Jul. PMID 12840045, Free PMC Article
  4. Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality. Ono R, et al. Nat Genet, 2006 Jan. PMID 16341224
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC6840

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-acetylneuraminate 9-O-acetyltransferase
Names
CAS1 domain-containing protein 1
O-acetyltransferase
sialate O-acetyltransferase
NP_001366072.1
NP_001366073.1
NP_001366074.1
NP_663373.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379143.1 → NP_001366072.1  N-acetylneuraminate 9-O-acetyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC091395
    Conserved Domains (1) summary
    pfam07779
    Location:299 → 741
    Cas1_AcylT; 10 TM Acyl Transferase domain found in Cas1p

  2. NM_001379144.1 → NP_001366073.1  N-acetylneuraminate 9-O-acetyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC091395
    Conserved Domains (1) summary
    pfam07779
    Location:171 → 647
    Cas1_AcylT; 10 TM Acyl Transferase domain found in Cas1p

  3. NM_001379145.1 → NP_001366074.1  N-acetylneuraminate 9-O-acetyltransferase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC091395
    Conserved Domains (1) summary
    pfam07779
    Location:16 → 492
    Cas1_AcylT; 10 TM Acyl Transferase domain found in Cas1p

  4. NM_145398.4 → NP_663373.2  N-acetylneuraminate 9-O-acetyltransferase isoform 1

    See identical proteins and their annotated locations for NP_663373.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC091395
    Consensus CDS
    CCDS19896.1
    UniProtKB/Swiss-Prot
    Q1RN01, Q6PD39, Q7TN73, Q8VEF5
    Related
    ENSMUSP00000015333.6, ENSMUST00000015333.12
    Conserved Domains (2) summary
    pfam07779
    Location:299 → 775
    Cas1_AcylT; 10 TM Acyl Transferase domain found in Cas1p
    pfam13839
    Location:73 → 292
    PC-Esterase; GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p

RNA

  1. NR_166521.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091395

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    4600911..4643355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TN73.1 GenPept UniProtKB/Swiss-Prot:Q7TN73

Gene LinkOut

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