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Plekhg1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 [ Mus musculus (house mouse) ]

Gene ID: 213783, updated on 5-Mar-2024

Summary

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Official Symbol
Plekhg1provided by MGI
Official Full Name
pleckstrin homology domain containing, family G (with RhoGef domain) member 1provided by MGI
Primary source
MGI:MGI:2676551
See related
Ensembl:ENSMUSG00000040624 AllianceGenome:MGI:2676551
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm521; mKIAA1209; D10Ertd733e
Summary
Predicted to be located in nucleoplasm. Is expressed in brain; embryo; and retina. Orthologous to human PLEKHG1 (pleckstrin homology and RhoGEF domain containing G1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 3.8), limb E14.5 (RPKM 3.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 A1; 10 2.06 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (3690206..3917303)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (3740251..3967303)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene iodotyrosine deiodinase Neighboring gene STARR-seq mESC enhancer starr_25674 Neighboring gene RIKEN cDNA A330032P22 gene Neighboring gene predicted gene, 30164 Neighboring gene STARR-seq mESC enhancer starr_25673 Neighboring gene STARR-seq mESC enhancer starr_25672 Neighboring gene STARR-seq mESC enhancer starr_25671 Neighboring gene STARR-seq mESC enhancer starr_25666 Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2926 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like Neighboring gene ring finger protein 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25663 Neighboring gene STARR-seq mESC enhancer starr_25662 Neighboring gene predicted gene, 40591

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus. Huisman C, et al. Nat Commun, 2021 Jan 11. PMID 33431871, Free PMC Article
  2. A Role for Sensory end Organ-Derived Signals in Regulating Muscle Spindle Proprioceptor Phenotype. Wu D, et al. J Neurosci, 2019 May 29. PMID 30926747, Free PMC Article
  3. The spatiotemporal expression pattern of microRNAs in the developing mouse nervous system. Shu P, et al. J Biol Chem, 2019 Mar 8. PMID 30578296, Free PMC Article
  4. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
  5. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family G member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033253.3 → NP_001028425.1  pleckstrin homology domain-containing family G member 1

    See identical proteins and their annotated locations for NP_001028425.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC153570, AK135923
    Consensus CDS
    CCDS56671.1
    UniProtKB/TrEMBL
    F6S200, Q3UX37
    Related
    ENSMUSP00000040495.7, ENSMUST00000042438.13
    Conserved Domains (2) summary
    cd00160
    Location:114 → 290
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13243
    Location:272 → 417
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

  2. NM_001159942.1 → NP_001153414.1  pleckstrin homology domain-containing family G member 1

    See identical proteins and their annotated locations for NP_001153414.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC153570, AK034403, AK135923
    Consensus CDS
    CCDS56671.1
    UniProtKB/TrEMBL
    F6S200, Q3UX37
    Related
    ENSMUSP00000114056.2, ENSMUST00000120274.8
    Conserved Domains (2) summary
    cd00160
    Location:114 → 290
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13243
    Location:272 → 417
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    3690206..3917303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243078.2 → XP_011241380.1  pleckstrin homology domain-containing family G member 1 isoform X3

    See identical proteins and their annotated locations for XP_011241380.1

    UniProtKB/TrEMBL
    F6S200, Q3UX37
    Conserved Domains (2) summary
    cd00160
    Location:114 → 290
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13243
    Location:272 → 417
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

  2. XM_011243077.2 → XP_011241379.1  pleckstrin homology domain-containing family G member 1 isoform X3

    See identical proteins and their annotated locations for XP_011241379.1

    UniProtKB/TrEMBL
    F6S200, Q3UX37
    Conserved Domains (2) summary
    cd00160
    Location:114 → 290
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13243
    Location:272 → 417
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

  3. XM_006512439.5 → XP_006512502.1  pleckstrin homology domain-containing family G member 1 isoform X1

    UniProtKB/TrEMBL
    A0A5F8MPP0
    Related
    ENSMUSP00000159056.2, ENSMUST00000239159.2
    Conserved Domains (2) summary
    cd00160
    Location:211 → 387
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13243
    Location:369 → 514
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

  4. XM_006512442.5 → XP_006512505.1  pleckstrin homology domain-containing family G member 1 isoform X2

    UniProtKB/TrEMBL
    F6S200
    Conserved Domains (2) summary
    cd00160
    Location:154 → 330
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13243
    Location:312 → 457
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

  5. XM_006512443.5 → XP_006512506.1  pleckstrin homology domain-containing family G member 1 isoform X3

    See identical proteins and their annotated locations for XP_006512506.1

    UniProtKB/TrEMBL
    F6S200, Q3UX37
    Conserved Domains (2) summary
    cd00160
    Location:114 → 290
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13243
    Location:272 → 417
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

RNA

  1. XR_004936151.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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