U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Prepl prolyl endopeptidase-like [ Mus musculus (house mouse) ]

Gene ID: 213760, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Preplprovided by MGI
Official Full Name
prolyl endopeptidase-likeprovided by MGI
Primary source
MGI:MGI:2441932
See related
Ensembl:ENSMUSG00000024127 AllianceGenome:MGI:2441932
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0436; 2810457N15Rik; 9530014L06Rik; D030028O16Rik
Summary
Enables peptidase activity. Involved in Golgi to plasma membrane protein transport and retrograde transport, endosome to Golgi. Located in Golgi apparatus and cytoskeleton. Colocalizes with trans-Golgi network. Is expressed in several structures, including diaphragm; nervous system; retina; tongue; and vertebral axis musculature. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 22. Orthologous to human PREPL (prolyl endopeptidase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 82.5), cortex adult (RPKM 70.3) and 21 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17 E4; 17 55.19 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (85370122..85397702, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (85062511..85090504, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43453 Neighboring gene post-GPI attachment to proteins 2 pseudogene Neighboring gene RIKEN cDNA 1110020A21 gene Neighboring gene STARR-seq mESC enhancer starr_43455 Neighboring gene STARR-seq mESC enhancer starr_43456 Neighboring gene STARR-positive B cell enhancer mm9_chr17:85356735-85357036 Neighboring gene STARR-seq mESC enhancer starr_43457 Neighboring gene protein phosphatase 1B, magnesium dependent, beta isoform Neighboring gene STARR-positive B cell enhancer ABC_E9445 Neighboring gene solute carrier family 3, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E4233 Neighboring gene STARR-seq mESC enhancer starr_43458 Neighboring gene calmodulin-lysine N-methyltransferase Neighboring gene STARR-seq mESC enhancer starr_43460 Neighboring gene STARR-seq mESC enhancer starr_43463 Neighboring gene STARR-positive B cell enhancer mm9_chr17:85588997-85589298 Neighboring gene STARR-seq mESC enhancer starr_43464 Neighboring gene predicted gene, 36826 Neighboring gene STARR-seq mESC enhancer starr_43465 Neighboring gene STARR-seq mESC enhancer starr_43466 Neighboring gene STARR-seq mESC enhancer starr_43468 Neighboring gene STARR-seq mESC enhancer starr_43469 Neighboring gene ribosomal protein L31, pseudogene 16

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Deletion of PREPl causes growth impairment and hypotonia in mice. Lone AM, et al. PLoS One, 2014. PMID 24586561, Free PMC Article
  2. Multiomics Analyses Identify Proline Endopeptidase-Like Protein As a Key Regulator of Protein Trafficking, a Pathway Underlying Alzheimer's Disease Pathogenesis. Duarte ML, et al. Mol Pharmacol, 2023 Jul. PMID 37147110, Free PMC Article
  3. A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. Lone AM, et al. J Am Chem Soc, 2011 Aug 3. PMID 21692504, Free PMC Article
  4. Cellular and ultra structural evidence for cytoskeletal localization of prolyl endopeptidase-like protein in neurons. Morawski M, et al. Neuroscience, 2013 Jul 9. PMID 23485813
  5. Trans-Golgi network morphology and sorting is regulated by prolyl-oligopeptidase-like protein PREPL and the AP-1 complex subunit μ1A. Radhakrishnan K, et al. J Cell Sci, 2013 Mar 1. PMID 23321636

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Multiomics Analyses Identify Proline Endopeptidase-Like Protein As a Key Regulator of Protein Trafficking, a Pathway Underlying Alzheimer's Disease Pathogenesis.
    Title: Multiomics Analyses Identify Proline Endopeptidase-Like Protein As a Key Regulator of Protein Trafficking, a Pathway Underlying Alzheimer's Disease Pathogenesis.
  2. The data demonstrate PREPL as an AP-1 effector that takes part in the regulation of AP-1 membrane binding. PREPL is highly expressed in brain and at lower levels in muscle and kidney.
    Title: Trans-Golgi network morphology and sorting is regulated by prolyl-oligopeptidase-like protein PREPL and the AP-1 complex subunit μ1A.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC7980

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with trans-Golgi network IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
prolyl endopeptidase-like
NP_001157094.1
NP_001157095.1
NP_001157096.1
NP_666096.3
XP_006524064.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163622.1 → NP_001157094.1  prolyl endopeptidase-like isoform a

    See identical proteins and their annotated locations for NP_001157094.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK028877, AK083070, BU058006, BY146774
    Consensus CDS
    CCDS50202.1
    UniProtKB/Swiss-Prot
    Q3TR35, Q6ZQB4, Q8BUP5, Q8C167, Q99KJ9
    UniProtKB/TrEMBL
    Q8BKS6
    Related
    ENSMUSP00000130967.2, ENSMUST00000171795.9
    Conserved Domains (2) summary
    COG1770
    Location:113 → 661
    PtrB; Protease II [Amino acid transport and metabolism]
    cl21494
    Location:487 → 647
    Abhydrolase; alpha/beta hydrolases

  2. NM_001163623.1 → NP_001157095.1  prolyl endopeptidase-like isoform b

    See identical proteins and their annotated locations for NP_001157095.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 1, 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AK050878, AK083070, BU058006, BY146774
    Consensus CDS
    CCDS29005.1
    UniProtKB/TrEMBL
    Q8BKS6
    Related
    ENSMUSP00000072239.4, ENSMUST00000072406.5
    Conserved Domains (1) summary
    COG1770
    Location:26 → 574
    PtrB; Protease II [Amino acid transport and metabolism]

  3. NM_001163624.1 → NP_001157096.1  prolyl endopeptidase-like isoform b

    See identical proteins and their annotated locations for NP_001157096.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 1, 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AK050878, AK083070, BU058006, BY257815
    Consensus CDS
    CCDS29005.1
    UniProtKB/TrEMBL
    Q8BKS6
    Conserved Domains (1) summary
    COG1770
    Location:26 → 574
    PtrB; Protease II [Amino acid transport and metabolism]

  4. NM_145984.3 → NP_666096.3  prolyl endopeptidase-like isoform b

    See identical proteins and their annotated locations for NP_666096.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 1, 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AK050878, AK083070, BU058006, BY146774
    Consensus CDS
    CCDS29005.1
    UniProtKB/TrEMBL
    Q8BKS6
    Conserved Domains (1) summary
    COG1770
    Location:26 → 574
    PtrB; Protease II [Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    85370122..85397702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524001.5 → XP_006524064.1  prolyl endopeptidase-like isoform X1

    See identical proteins and their annotated locations for XP_006524064.1

    UniProtKB/TrEMBL
    Q8BKS6
    Conserved Domains (1) summary
    COG1770
    Location:26 → 574
    PtrB; Protease II [Amino acid transport and metabolism]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C167.1 GenPept UniProtKB/Swiss-Prot:Q8C167

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous