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Zfp598 zinc finger protein 598 [ Mus musculus (house mouse) ]

Gene ID: 213753, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp598provided by MGI
Official Full Name
zinc finger protein 598provided by MGI
Primary source
MGI:MGI:2670965
See related
Ensembl:ENSMUSG00000041130 AllianceGenome:MGI:2670965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ntrap; Znf598
Summary
Predicted to enable ribosome binding activity and ubiquitin protein ligase activity. Predicted to be involved in protein monoubiquitination; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within regulation of translation. Predicted to be located in cytosol. Is expressed in early conceptus; future spinal cord; inner cell mass; and oocyte. Orthologous to human ZNF598 (zinc finger protein 598, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 52.8), ovary adult (RPKM 51.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 12.46 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24888661..24900997)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24669687..24682023)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene NHERF family PDZ scaffold protein 2 Neighboring gene neuropeptide W Neighboring gene STARR-positive B cell enhancer ABC_E11630 Neighboring gene synaptogyrin 3 Neighboring gene growth factor, augmenter of liver regeneration

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Retrograde neurotrophic signaling requires a protein interacting with receptor tyrosine kinases via C2H2 zinc fingers. Fu X, et al. Mol Biol Cell, 2010 Jan 1. PMID 19864463, Free PMC Article
  2. Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord. Masuda T, et al. Brain Res, 2009 Jan 16. PMID 19026994
  3. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
  4. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
  5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NTRAP regulates retrograde neurotrophic signaling by controlling the formation of signaling endosomes.
    Title: Retrograde neurotrophic signaling requires a protein interacting with receptor tyrosine kinases via C2H2 zinc fingers.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-RNA adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
enables stalled ribosome sensor activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in rescue of stalled ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase ZNF598
NP_001335160.1
NP_898972.1
XP_006524063.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348231.1 → NP_001335160.1  E3 ubiquitin-protein ligase ZNF598 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC154566, BC050859, BQ180106, CF537189
    Consensus CDS
    CCDS89013.1
    UniProtKB/Swiss-Prot
    Q80YR4
    Related
    ENSMUSP00000038367.7, ENSMUST00000047179.7
    Conserved Domains (2) summary
    COG5236
    Location:27 → 336
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cl26464
    Location:366 → 675
    Atrophin-1; Atrophin-1 family

  2. NM_183149.2 → NP_898972.1  E3 ubiquitin-protein ligase ZNF598 isoform 1

    See identical proteins and their annotated locations for NP_898972.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC154566, BC050859, CF537189
    Consensus CDS
    CCDS28490.1
    UniProtKB/Swiss-Prot
    Q6KAT0, Q80YR4, Q8R3S1
    Related
    ENSMUSP00000157172.2, ENSMUST00000234956.2
    Conserved Domains (1) summary
    COG5236
    Location:27 → 326
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24888661..24900997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524000.1 → XP_006524063.1  E3 ubiquitin-protein ligase ZNF598 isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:198 → 507
    PHA03247; large tegument protein UL36; Provisional
    COG5236
    Location:11 → 155
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80YR4.1 GenPept UniProtKB/Swiss-Prot:Q80YR4

Gene LinkOut

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