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Duoxa1 dual oxidase maturation factor 1 [ Mus musculus (house mouse) ]

Gene ID: 213696, updated on 11-Apr-2024

Summary

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Official Symbol
Duoxa1provided by MGI
Official Full Name
dual oxidase maturation factor 1provided by MGI
Primary source
MGI:MGI:2384861
See related
Ensembl:ENSMUSG00000027224 AllianceGenome:MGI:2384861
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nip; Nip1
Summary
Predicted to enable enzyme binding activity. Acts upstream of or within several processes, including hydrogen peroxide metabolic process; positive regulation of reactive oxygen species metabolic process; and regulation of thyroid hormone generation. Located in plasma membrane. Is expressed in several structures, including brain; genitourinary system; heart; and skeletal muscle. Orthologous to human DUOXA1 (dual oxidase maturation factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 7.2), mammary gland adult (RPKM 5.1) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E5; 2 60.62 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (122134012..122144255, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122303540..122313763, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene dual oxidase 2 Neighboring gene dual oxidase maturation factor 2 Neighboring gene dual oxidase 1 Neighboring gene STARR-seq mESC enhancer starr_05553 Neighboring gene Src homology 2 domain containing F Neighboring gene STARR-positive B cell enhancer ABC_E10134 Neighboring gene STARR-seq mESC enhancer starr_05555 Neighboring gene STARR-positive B cell enhancer ABC_E1253 Neighboring gene nuclear encoded tRNA histidine 4 (anticodon GTG) Neighboring gene predicted gene, 39918

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Aberrant Cerebellar Development in Mice Lacking Dual Oxidase Maturation Factors. Amano I, et al. Thyroid, 2016 May. PMID 26914863, Free PMC Article
  2. Dual oxidase maturation factor 1 (DUOXA1) overexpression increases reactive oxygen species production and inhibits murine muscle satellite cell differentiation. Sandiford SD, et al. Cell Commun Signal, 2014 Jan 11. PMID 24410844, Free PMC Article
  3. Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation. Sun J. Nat Struct Mol Biol, 2020 Nov. PMID 32929281, Free PMC Article
  4. Dual oxidases control release of hydrogen peroxide by the gastric epithelium to prevent Helicobacter felis infection and inflammation in mice. Grasberger H, et al. Gastroenterology, 2013 Nov. PMID 23860501, Free PMC Article
  5. Intestinal Epithelial Cells Respond to Chronic Inflammation and Dysbiosis by Synthesizing H(2)O(2). Burgueño JF, et al. Front Physiol, 2019. PMID 31871440, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation.
    Title: Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation.
  2. The proliferation and migration of granule cells was delayed after P15 in Duoxa-/- mice. However, these changes disappeared by P25. Although the cerebellar structure of Duoxa-/- mice was not significantly different from that of Wt mice at P25, motor coordination was impaired. It was also found that the amplitude of paired-pulse facilitation at parallel fiber-Purkinje cell synapses decreased in Duoxa-/- mice.
    Title: Aberrant Cerebellar Development in Mice Lacking Dual Oxidase Maturation Factors.
  3. DUOXA1 overexpression in muscle stem cells induces apoptosis and inhibits differentiation through DUOX1 and ASK1.
    Title: Dual oxidase maturation factor 1 (DUOXA1) overexpression increases reactive oxygen species production and inhibits murine muscle satellite cell differentiation.
  4. DUOXA1 is a novel p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation.
    Title: p53-mediated regulation of neuronal differentiation via regulation of dual oxidase maturation factor 1.
  5. Nip1 has an important role in the guidance of neuronal differentiation through ROS generation and modulation of intermediate filaments
    Title: Mammalian numb-interacting protein 1/dual oxidase maturation factor 1 directs neuronal fate in stem cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Homology

Clone Names

  • MGC25550

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within hydrogen peroxide metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of hydrogen peroxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of reactive oxygen species metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of thyroid hormone generation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dual oxidase maturation factor 1
Names
Numb-interacting protein 1
dual oxidase activator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305262.1 → NP_001292191.1  dual oxidase maturation factor 1

    See identical proteins and their annotated locations for NP_001292191.1

    Status: VALIDATED

    Source sequence(s)
    AL844566, CO039809
    Consensus CDS
    CCDS16661.1
    UniProtKB/Swiss-Prot
    A2AQ97, Q8VE49
    UniProtKB/TrEMBL
    A2AQ96
    Related
    ENSMUSP00000106166.2, ENSMUST00000110537.8
    Conserved Domains (1) summary
    pfam10204
    Location:11 → 283
    DuoxA; Dual oxidase maturation factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    122134012..122144255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499094.5 → XP_006499157.1  dual oxidase maturation factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006499157.1

    UniProtKB/Swiss-Prot
    A2AQ97, Q8VE49
    UniProtKB/TrEMBL
    A2AQ96
    Related
    ENSMUSP00000028653.8, ENSMUST00000028653.14
    Conserved Domains (1) summary
    pfam10204
    Location:11 → 283
    DuoxA; Dual oxidase maturation factor

  2. XM_017316921.3 → XP_017172410.1  dual oxidase maturation factor 1 isoform X1

    UniProtKB/Swiss-Prot
    A2AQ97, Q8VE49
    UniProtKB/TrEMBL
    A2AQ96
    Conserved Domains (1) summary
    pfam10204
    Location:11 → 283
    DuoxA; Dual oxidase maturation factor

  3. XM_006499091.5 → XP_006499154.1  dual oxidase maturation factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006499154.1

    UniProtKB/Swiss-Prot
    A2AQ97, Q8VE49
    UniProtKB/TrEMBL
    A2AQ96
    Conserved Domains (1) summary
    pfam10204
    Location:11 → 283
    DuoxA; Dual oxidase maturation factor

  4. XM_006499095.5 → XP_006499158.1  dual oxidase maturation factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006499158.1

    UniProtKB/Swiss-Prot
    A2AQ97, Q8VE49
    UniProtKB/TrEMBL
    A2AQ96
    Conserved Domains (1) summary
    pfam10204
    Location:11 → 283
    DuoxA; Dual oxidase maturation factor

RNA

  1. XR_003951826.2 RNA Sequence

  2. XR_004939454.1 RNA Sequence

  3. XR_003951824.2 RNA Sequence

  4. XR_003951827.2 RNA Sequence

  5. XR_003951825.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145395.2: Suppressed sequence

    Description
    NM_145395.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VE49.2 GenPept UniProtKB/Swiss-Prot:Q8VE49

Gene LinkOut

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