Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc6a6provided by MGI
Official Full Name: solute carrier family 6 (neurotransmitter transporter, taurine), member 6provided by MGI
Primary source: MGI:MGI:98488
See related: Ensembl:ENSMUSG00000030096 AllianceGenome:MGI:98488
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Taut
Summary: Enables beta-alanine transmembrane transporter activity and taurine transmembrane transporter activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within beta-alanine transport and taurine transport. Located in GABA-ergic synapse. Is integral component of postsynaptic membrane. Is expressed in several structures, including cardiovascular system; central nervous system; placenta; retina; and tooth. Used to study retinitis pigmentosa. Orthologous to human SLC6A6 (solute carrier family 6 member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 68.2), kidney adult (RPKM 51.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 40.73 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (91661031..91736044)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (91684048..91759063)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of Pdk1 drives heart failure by impairing taurine homeostasis through Slc6a6.
Title: Deficiency of Pdk1 drives heart failure by impairing taurine homeostasis through Slc6a6.
Characterization of Bone Tissue and Bone Morphology in Taurine Transporter Knockout Mice.
Title: Characterization of Bone Tissue and Bone Morphology in Taurine Transporter Knockout Mice.
Significance of taurine transporter (TauT) in homeostasis and its layers of regulation (Review).
Title: Significance of taurine transporter (TauT) in homeostasis and its layers of regulation (Review).
Evaluation of the neuroprotective effect of taurine in Alzheimer's disease using functional molecular imaging.
Title: Evaluation of the neuroprotective effect of taurine in Alzheimer's disease using functional molecular imaging.
Circulating levels of GDF15 were elevated in old slc6a6 knockout mice
Title: Induction of Growth Differentiation Factor 15 in Skeletal Muscle of Old Taurine Transporter Knockout Mouse.
These findings suggest that TauT protein expression is relatively insensitive to changes in muscle taurine content in WT and mdx mice, and that taurine and beta-alanine supplementation may be viable therapeutic strategies to improve fatigue resistance of dystrophic skeletal muscle.
Title: The effect of taurine and β-alanine supplementation on taurine transporter protein and fatigue resistance in skeletal muscle from mdx mice.
This study evaluated the role of taurine and its transporter on pancreatic islet cells and insulin secretion.
Title: Protein malnutrition blunts the increment of taurine transporter expression by a high-fat diet and impairs taurine reestablishment of insulin secretion.
both homozygous and heterozygous TauT gene deletion predispose C57BL/6 mice to develop end-stage diabetic kidney disease
Title: Knockout of the TauT gene predisposes C57BL/6 mice to streptozotocin-induced diabetic nephropathy.
This study demonistrated that intracellular taurine deficits lead in particular to a hyposensitivity of nociceptive sensory neurons sensitive to noxious chemical stimulation.
Title: Congenital taurine deficiency in mice is associated with reduced sensitivity to nociceptive chemical stimulation.
Studied protective effect of taurine associated with the upregulation of TAUT expression in acute myocardial ischemia. Data showed that taurine reversed the apoptosis induced by hypoxia and AMI, thereby, effectively protecting the myocardium.
Title: Low-dose taurine upregulates taurine transporter expression in acute myocardial ischemia.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Gene trapped (1)
Chemically induced (ENU) (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125023 (e-PCR)
- UniSTS:161845

AA589629 (e-PCR)
- UniSTS:159542

C80501 (e-PCR)
- UniSTS:159543

Slc6a6 (e-PCR), detects polymorphism
- UniSTS:547132

AW531182 (e-PCR)
- UniSTS:245086

Slc6a6 (e-PCR), detects polymorphism
- UniSTS:516488

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables amino acid:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables beta-alanine transmembrane transporter activity	IDA Inferred from Direct Assay more info
enables gamma-aminobutyric acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables gamma-aminobutyric acid:sodium:chloride symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables gamma-aminobutyric acid:sodium:chloride symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables gamma-aminobutyric acid:sodium:chloride symporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables taurine binding	ISO Inferred from Sequence Orthology more info
enables taurine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables taurine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables taurine:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables taurine:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables taurine:sodium symporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in alanine transport	ISO Inferred from Sequence Orthology more info
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in amino acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within beta-alanine transport	IDA Inferred from Direct Assay more info
involved_in gamma-aminobutyric acid import	ISO Inferred from Sequence Orthology more info
involved_in import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of nitrogen compound transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in taurine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within taurine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within taurine transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in taurine transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of plasma membrane protein complex	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: sodium- and chloride-dependent taurine transporter

Names: solute carrier family 6 member 6; taurine/beta-alanine transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410446.1 → NP_001397375.1 sodium- and chloride-dependent taurine transporter isoform a

Status: VALIDATED

Source sequence(s)

AC162914

UniProtKB/Swiss-Prot

O35316, P31642, Q91WI2

UniProtKB/TrEMBL

Q3UPI8
NM_001410447.1 → NP_001397376.1 sodium- and chloride-dependent taurine transporter isoform a

Status: VALIDATED

Source sequence(s)

AC162914

UniProtKB/Swiss-Prot

O35316, P31642, Q91WI2

UniProtKB/TrEMBL

Q3UPI8
NM_001410448.1 → NP_001397377.1 sodium- and chloride-dependent taurine transporter isoform b

Status: VALIDATED

Source sequence(s)

AC162914
NM_001410449.1 → NP_001397378.1 sodium- and chloride-dependent taurine transporter isoform c

Status: VALIDATED

Source sequence(s)

AC162914
NM_001410450.1 → NP_001397379.1 sodium- and chloride-dependent taurine transporter isoform d

Status: VALIDATED

Source sequence(s)

AC162914
NM_001410451.1 → NP_001397380.1 sodium- and chloride-dependent taurine transporter isoform e

Status: VALIDATED

Source sequence(s)

AC162914

UniProtKB/TrEMBL

Q8BRX2

Related

ENSMUST00000206835.2
NM_001410452.1 → NP_001397381.1 sodium- and chloride-dependent taurine transporter isoform e

Status: VALIDATED

Source sequence(s)

AC162914

UniProtKB/TrEMBL

Q8BRX2
NM_009320.5 → NP_033346.2 sodium- and chloride-dependent taurine transporter isoform a

See identical proteins and their annotated locations for NP_033346.2

Status: VALIDATED

Source sequence(s)

AC162914

Consensus CDS

CCDS39570.1

UniProtKB/Swiss-Prot

O35316, P31642, Q91WI2

UniProtKB/TrEMBL

Q3UPI8

Related

ENSMUSP00000032185.8, ENSMUST00000032185.9

Conserved Domains (1) summary

cl00456
Location:41 → 582

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RNA

NR_177072.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC162914
NR_177073.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC162914

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

91661031..91736044

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036166008.1 → XP_036021901.1 sodium- and chloride-dependent taurine transporter isoform X2

UniProtKB/Swiss-Prot

O35316, P31642, Q91WI2

UniProtKB/TrEMBL

Q3UPI8

Conserved Domains (1) summary

cl00456
Location:41 → 582

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_030255304.2 → XP_030111164.1 sodium- and chloride-dependent taurine transporter isoform X2

UniProtKB/Swiss-Prot

O35316, P31642, Q91WI2

UniProtKB/TrEMBL

Q3UPI8

Conserved Domains (1) summary

cl00456
Location:41 → 582

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006505870.2 → XP_006505933.1 sodium- and chloride-dependent taurine transporter isoform X2

See identical proteins and their annotated locations for XP_006505933.1

UniProtKB/Swiss-Prot

O35316, P31642, Q91WI2

UniProtKB/TrEMBL

Q3UPI8

Conserved Domains (1) summary

cl00456
Location:41 → 582

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_036166010.1 → XP_036021903.1 sodium- and chloride-dependent taurine transporter isoform X2

UniProtKB/Swiss-Prot

O35316, P31642, Q91WI2

UniProtKB/TrEMBL

Q3UPI8

Conserved Domains (1) summary

cl00456
Location:41 → 582

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain