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Plekhh2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 [ Mus musculus (house mouse) ]

Gene ID: 213556, updated on 5-Mar-2024

Summary

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Official Symbol
Plekhh2provided by MGI
Official Full Name
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2provided by MGI
Primary source
MGI:MGI:2146813
See related
Ensembl:ENSMUSG00000040852 AllianceGenome:MGI:2146813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA2028; E030001K05
Summary
Enables actin binding activity. Involved in negative regulation of actin filament depolymerization. Located in cortical actin cytoskeleton. Is expressed in s-shaped body. Orthologous to human PLEKHH2 (pleckstrin homology, MyTH4 and FERM domain containing H2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 12.4), limb E14.5 (RPKM 7.5) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Plekhh2 in Genome Data Viewer
Location:
17 E4; 17 55.02 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (84819303..84929571)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (84511895..84622143)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene thyroid adenoma associated Neighboring gene VISTA enhancer mm1109 Neighboring gene predicted gene, 24722 Neighboring gene STARR-positive B cell enhancer ABC_E7562 Neighboring gene STARR-positive B cell enhancer ABC_E5638 Neighboring gene STARR-seq mESC enhancer starr_43440 Neighboring gene predicted gene, 41642 Neighboring gene RIKEN cDNA 4930500A05 gene Neighboring gene dynein cytoplasmic 2 light intermediate chain 1 Neighboring gene predicted gene, 26066

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics. Perisic L, et al. Kidney Int, 2012 Nov. PMID 22832517
  2. Defining the molecular character of the developing and adult kidney podocyte. Brunskill EW, et al. PLoS One, 2011. PMID 21931791, Free PMC Article
  3. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
  4. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Suggest a structural and functional role for Plekhh2 in the podocyte foot processes.
    Title: Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC159286

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of actin filament depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of actin filament depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family H member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357986.1 → NP_001344915.1  pleckstrin homology domain-containing family H member 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132353, AC139329, BP757711
    Consensus CDS
    CCDS28999.1
    UniProtKB/Swiss-Prot
    B2RQ85, Q059P2, Q69Z29, Q8C115, Q8VDL8
    Conserved Domains (7) summary
    smart00139
    Location:954 → 1109
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:1122 → 1353
    B41; Band 4.1 homologues
    COG1196
    Location:20 → 252
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13206
    Location:1349 → 1447
    FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
    cd13282
    Location:705 → 800
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cd17179
    Location:1119 → 1221
    FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
    cl17171
    Location:803 → 916
    PH-like; Pleckstrin homology-like domain

  2. NM_001357987.1 → NP_001344916.1  pleckstrin homology domain-containing family H member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132353, AC139329, BP757711
    Conserved Domains (6) summary
    smart00139
    Location:651 → 806
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:819 → 1050
    B41; Band 4.1 homologues
    cd13206
    Location:1046 → 1144
    FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
    cd13282
    Location:402 → 497
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cl17171
    Location:500 → 613
    PH-like; Pleckstrin homology-like domain
    cl25732
    Location:20 → 252
    SMC_N; RecF/RecN/SMC N terminal domain

  3. NM_177606.4 → NP_808274.2  pleckstrin homology domain-containing family H member 2 isoform 1

    See identical proteins and their annotated locations for NP_808274.2

    Status: VALIDATED

    Source sequence(s)
    AC132353, AC139329
    Consensus CDS
    CCDS28999.1
    UniProtKB/Swiss-Prot
    B2RQ85, Q059P2, Q69Z29, Q8C115, Q8VDL8
    Related
    ENSMUSP00000039628.6, ENSMUST00000047206.7
    Conserved Domains (7) summary
    smart00139
    Location:954 → 1109
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:1122 → 1353
    B41; Band 4.1 homologues
    COG1196
    Location:20 → 252
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13206
    Location:1349 → 1447
    FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
    cd13282
    Location:705 → 800
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cd17179
    Location:1119 → 1221
    FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
    cl17171
    Location:803 → 916
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    84819303..84929571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160458.1 → XP_036016351.1  pleckstrin homology domain-containing family H member 2 isoform X1

    Conserved Domains (7) summary
    smart00139
    Location:1003 → 1158
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:1171 → 1402
    B41; Band 4.1 homologues
    COG1196
    Location:83 → 301
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13206
    Location:1398 → 1496
    FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
    cd13282
    Location:754 → 849
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cd17179
    Location:1168 → 1270
    FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
    cl17171
    Location:852 → 965
    PH-like; Pleckstrin homology-like domain

  2. XM_036160460.1 → XP_036016353.1  pleckstrin homology domain-containing family H member 2 isoform X4

    Conserved Domains (7) summary
    smart00139
    Location:889 → 1044
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:1057 → 1288
    B41; Band 4.1 homologues
    COG1196
    Location:3 → 187
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13206
    Location:1284 → 1382
    FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
    cd13282
    Location:640 → 735
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cd17179
    Location:1054 → 1156
    FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
    cl17171
    Location:738 → 851
    PH-like; Pleckstrin homology-like domain

  3. XM_030249636.2 → XP_030105496.1  pleckstrin homology domain-containing family H member 2 isoform X8

    Conserved Domains (6) summary
    smart00139
    Location:395 → 550
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:563 → 794
    B41; Band 4.1 homologues
    cd13206
    Location:790 → 888
    FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
    cd13282
    Location:146 → 241
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cd17179
    Location:560 → 662
    FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
    cl17171
    Location:244 → 357
    PH-like; Pleckstrin homology-like domain

  4. XM_036160462.1 → XP_036016355.1  pleckstrin homology domain-containing family H member 2 isoform X7

    Conserved Domains (6) summary
    smart00139
    Location:407 → 562
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:575 → 806
    B41; Band 4.1 homologues
    cd13206
    Location:802 → 900
    FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
    cd13282
    Location:158 → 253
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cd17179
    Location:572 → 674
    FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
    cl17171
    Location:256 → 369
    PH-like; Pleckstrin homology-like domain

  5. XM_036160461.1 → XP_036016354.1  pleckstrin homology domain-containing family H member 2 isoform X5

    Conserved Domains (6) summary
    smart00139
    Location:742 → 897
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:910 → 1141
    B41; Band 4.1 homologues
    cd13206
    Location:1137 → 1235
    FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
    cd13282
    Location:493 → 588
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cd17179
    Location:907 → 1009
    FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
    cl17171
    Location:591 → 704
    PH-like; Pleckstrin homology-like domain

  6. XM_036160459.1 → XP_036016352.1  pleckstrin homology domain-containing family H member 2 isoform X1

    Conserved Domains (7) summary
    smart00139
    Location:1003 → 1158
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:1171 → 1402
    B41; Band 4.1 homologues
    COG1196
    Location:83 → 301
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13206
    Location:1398 → 1496
    FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
    cd13282
    Location:754 → 849
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cd17179
    Location:1168 → 1270
    FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
    cl17171
    Location:852 → 965
    PH-like; Pleckstrin homology-like domain

  7. XM_006523993.5 → XP_006524056.1  pleckstrin homology domain-containing family H member 2 isoform X2

    See identical proteins and their annotated locations for XP_006524056.1

    UniProtKB/Swiss-Prot
    B2RQ85, Q059P2, Q69Z29, Q8C115, Q8VDL8
    Conserved Domains (7) summary
    smart00139
    Location:954 → 1109
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:1122 → 1353
    B41; Band 4.1 homologues
    COG1196
    Location:20 → 252
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13206
    Location:1349 → 1447
    FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
    cd13282
    Location:705 → 800
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cd17179
    Location:1119 → 1221
    FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
    cl17171
    Location:803 → 916
    PH-like; Pleckstrin homology-like domain

  8. XM_017317381.3 → XP_017172870.1  pleckstrin homology domain-containing family H member 2 isoform X2

    UniProtKB/Swiss-Prot
    B2RQ85, Q059P2, Q69Z29, Q8C115, Q8VDL8
    Conserved Domains (7) summary
    smart00139
    Location:954 → 1109
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:1122 → 1353
    B41; Band 4.1 homologues
    COG1196
    Location:20 → 252
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13206
    Location:1349 → 1447
    FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
    cd13282
    Location:705 → 800
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cd17179
    Location:1119 → 1221
    FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
    cl17171
    Location:803 → 916
    PH-like; Pleckstrin homology-like domain

  9. XM_011246358.4 → XP_011244660.1  pleckstrin homology domain-containing family H member 2 isoform X6

    Conserved Domains (7) summary
    smart00139
    Location:700 → 855
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:868 → 1099
    B41; Band 4.1 homologues
    COG1196
    Location:83 → 301
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13206
    Location:1095 → 1193
    FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
    cd13282
    Location:451 → 546
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cd17179
    Location:865 → 967
    FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
    cl17171
    Location:549 → 662
    PH-like; Pleckstrin homology-like domain

  10. XM_006523995.4 → XP_006524058.1  pleckstrin homology domain-containing family H member 2 isoform X3

    Conserved Domains (7) summary
    smart00139
    Location:913 → 1068
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:1081 → 1312
    B41; Band 4.1 homologues
    COG1196
    Location:1 → 211
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13206
    Location:1308 → 1406
    FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
    cd13282
    Location:664 → 759
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cd17179
    Location:1078 → 1180
    FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
    cl17171
    Location:762 → 875
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_876465.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C115.3 GenPept UniProtKB/Swiss-Prot:Q8C115

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