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Arhgef11 Rho guanine nucleotide exchange factor 11 [ Mus musculus (house mouse) ]

Gene ID: 213498, updated on 21-Apr-2024

Summary

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Official Symbol
Arhgef11provided by MGI
Official Full Name
Rho guanine nucleotide exchange factor 11provided by MGI
Primary source
MGI:MGI:2441869
See related
Ensembl:ENSMUSG00000041977 AllianceGenome:MGI:2441869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prg; RhoGEF; mKIAA0380; PDZ-RhoGEF
Summary
Predicted to enable G protein-coupled receptor binding activity. Predicted to be involved in Rho protein signal transduction and positive regulation of transcription, DNA-templated. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm. Is expressed in several structures, including adrenal gland; cardiovascular system; genitourinary system; gut; and nervous system. Orthologous to human ARHGEF11 (Rho guanine nucleotide exchange factor 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 16.7), lung adult (RPKM 15.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F1; 3 38.22 cM
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87524855..87645346)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87617548..87738039)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ets variant 3-like Neighboring gene predicted gene, 25167 Neighboring gene STARR-seq mESC enhancer starr_08160 Neighboring gene STARR-seq mESC enhancer starr_08161 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene predicted gene 6570 Neighboring gene leucine rich repeat containing 71 Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene neurotrophic tyrosine kinase, receptor, type 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes. Chang YJ, et al. Elife, 2015 Oct 29. PMID 26512886, Free PMC Article
  2. Arhgef1 Plays a Vital Role in Platelet Function and Thrombogenesis. Qasim H, et al. J Am Heart Assoc, 2019 May 7. PMID 30994039, Free PMC Article
  3. Rho GTP exchange factor ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-myosin II signaling. Itoh M, et al. Proc Natl Acad Sci U S A, 2012 Jun 19. PMID 22665792, Free PMC Article
  4. Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils. Francis SA, et al. Blood, 2006 Feb 15. PMID 16263795, Free PMC Article
  5. Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor. Barac A, et al. J Biol Chem, 2004 Feb 13. PMID 14625312

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the ablation of Esrp1 and Esrp2 impairs epithelial tight junction (TJ) integrity through loss of the epithelial isoform of Rho GTP exchange factor Arhgef11.
    Title: Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity.
  2. These results demonstrate that PDZ-RhoGEF acts as a key determinant of mammalian metabolism and obesity-associated pathologies.
    Title: The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes.
  3. Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.
    Title: Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.
  4. PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation.
    Title: PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation.
  5. results suggest that ARHGEF11 mediates RhoA-myosin light chain signaling pathways at cell-cell junctions, functioning in cooperation with ZO-1
    Title: Rho GTP exchange factor ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-myosin II signaling.
  6. PDZ-RhoGEF interacts directly with p21-activated kinase 4 to negatively regulate the activation of Rho
    Title: Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor.
  7. Required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils.
    Title: Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • KIAA0380, MGC90827, B930073M02, E130307F09

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of L-glutamate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 11
Names
Rho guanine nucleotide exchange factor (GEF) 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003912.3 → NP_001003912.1  rho guanine nucleotide exchange factor 11 isoform 1

    See identical proteins and their annotated locations for NP_001003912.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC139241, AC161454
    Consensus CDS
    CCDS38472.1
    UniProtKB/TrEMBL
    E9Q0A3, Q68FM7
    Related
    ENSMUSP00000039900.9, ENSMUST00000039476.15
    Conserved Domains (5) summary
    cd08753
    Location:330 → 474
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:61 → 137
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:46 → 120
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:969 → 1111
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:768 → 952
    RhoGEF; RhoGEF domain

  2. NM_001360195.2 → NP_001347124.1  rho guanine nucleotide exchange factor 11 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the 5' coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC139241, AC161454
    UniProtKB/TrEMBL
    E9Q0A3
    Related
    ENSMUSP00000118123.2, ENSMUST00000129113.8
    Conserved Domains (5) summary
    cd08753
    Location:290 → 434
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    smart00325
    Location:739 → 923
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:46 → 120
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:940 → 1082
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    cl26464
    Location:1071 → 1413
    Atrophin-1; Atrophin-1 family

  3. NM_001360197.2 → NP_001347126.1  rho guanine nucleotide exchange factor 11 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' region and uses a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC139241, AC161454
    Conserved Domains (3) summary
    PHA03247
    Location:450 → 792
    PHA03247; large tegument protein UL36; Provisional
    cd13391
    Location:319 → 461
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:118 → 301
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    87524855..87645346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501264.2 → XP_006501327.1  rho guanine nucleotide exchange factor 11 isoform X1

    UniProtKB/TrEMBL
    E9Q0A3
    Conserved Domains (5) summary
    cd08753
    Location:346 → 490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03247
    Location:1127 → 1469
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:996 → 1138
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:795 → 978
    RhoGEF; RhoGEF domain

  2. XM_006501272.2 → XP_006501335.1  rho guanine nucleotide exchange factor 11 isoform X13

    UniProtKB/TrEMBL
    E9Q0A3
    Conserved Domains (5) summary
    cd08753
    Location:346 → 490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03307
    Location:1169 → 1536
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:996 → 1138
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:795 → 978
    RhoGEF; RhoGEF domain

  3. XM_006501267.2 → XP_006501330.1  rho guanine nucleotide exchange factor 11 isoform X4

    UniProtKB/TrEMBL
    E9Q0A3
    Conserved Domains (5) summary
    cd08753
    Location:346 → 490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03247
    Location:1117 → 1459
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:986 → 1128
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:785 → 968
    RhoGEF; RhoGEF domain

  4. XM_006501265.2 → XP_006501328.1  rho guanine nucleotide exchange factor 11 isoform X2

    UniProtKB/TrEMBL
    E9Q0A3
    Conserved Domains (5) summary
    cd08753
    Location:346 → 490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03247
    Location:1126 → 1468
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:995 → 1137
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:794 → 977
    RhoGEF; RhoGEF domain

  5. XM_006501268.2 → XP_006501331.1  rho guanine nucleotide exchange factor 11 isoform X5

    UniProtKB/TrEMBL
    E9Q0A3
    Conserved Domains (5) summary
    cd08753
    Location:346 → 490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03247
    Location:1116 → 1458
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:985 → 1127
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:784 → 967
    RhoGEF; RhoGEF domain

  6. XM_036163000.1 → XP_036018893.1  rho guanine nucleotide exchange factor 11 isoform X18

    UniProtKB/TrEMBL
    E9Q0A3
    Conserved Domains (5) summary
    cd08753
    Location:346 → 490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    smart00325
    Location:784 → 968
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PHA03307
    Location:1158 → 1525
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:985 → 1127
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  7. XM_006501273.2 → XP_006501336.1  rho guanine nucleotide exchange factor 11 isoform X14

    UniProtKB/TrEMBL
    E9Q0A3
    Conserved Domains (5) summary
    cd08753
    Location:300 → 444
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03247
    Location:1081 → 1423
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:950 → 1092
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:749 → 932
    RhoGEF; RhoGEF domain

  8. XM_036163001.1 → XP_036018894.1  rho guanine nucleotide exchange factor 11 isoform X19

    UniProtKB/TrEMBL
    E9Q0A3
    Conserved Domains (5) summary
    cd08753
    Location:300 → 444
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    smart00325
    Location:739 → 923
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PHA03247
    Location:1071 → 1413
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:940 → 1082
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  9. XM_006501270.2 → XP_006501333.1  rho guanine nucleotide exchange factor 11 isoform X11

    UniProtKB/TrEMBL
    E9Q0A3
    Conserved Domains (5) summary
    cd08753
    Location:306 → 450
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03247
    Location:1087 → 1429
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:956 → 1098
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:755 → 938
    RhoGEF; RhoGEF domain

  10. XM_006501274.2 → XP_006501337.1  rho guanine nucleotide exchange factor 11 isoform X15

    UniProtKB/TrEMBL
    E9Q0A3
    Conserved Domains (5) summary
    cd08753
    Location:306 → 450
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03247
    Location:1077 → 1419
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:946 → 1088
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:745 → 928
    RhoGEF; RhoGEF domain

  11. XM_006501271.2 → XP_006501334.1  rho guanine nucleotide exchange factor 11 isoform X12

    UniProtKB/TrEMBL
    E9Q0A3
    Conserved Domains (5) summary
    cd08753
    Location:306 → 450
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03247
    Location:1086 → 1428
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:955 → 1097
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:754 → 937
    RhoGEF; RhoGEF domain

  12. XM_011240067.1 → XP_011238369.1  rho guanine nucleotide exchange factor 11 isoform X16

    UniProtKB/TrEMBL
    E9Q0A3
    Conserved Domains (5) summary
    cd08753
    Location:306 → 450
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03247
    Location:1076 → 1418
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:945 → 1087
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:744 → 927
    RhoGEF; RhoGEF domain

  13. XM_006501266.2 → XP_006501329.1  rho guanine nucleotide exchange factor 11 isoform X3

    UniProtKB/TrEMBL
    E9Q0A3
    Conserved Domains (5) summary
    cd08753
    Location:341 → 485
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03247
    Location:1122 → 1464
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:57 → 131
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:991 → 1133
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:790 → 973
    RhoGEF; RhoGEF domain

  14. XM_036162998.1 → XP_036018891.1  rho guanine nucleotide exchange factor 11 isoform X6

    UniProtKB/TrEMBL
    E9Q0A3
    Conserved Domains (5) summary
    cd08753
    Location:341 → 485
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    smart00325
    Location:780 → 964
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PHA03247
    Location:1112 → 1454
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:57 → 131
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:981 → 1123
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  15. XM_030252534.1 → XP_030108394.1  rho guanine nucleotide exchange factor 11 isoform X8

    UniProtKB/TrEMBL
    E9Q0A3
    Conserved Domains (5) summary
    cd08753
    Location:341 → 485
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03247
    Location:1111 → 1453
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:57 → 131
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:980 → 1122
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:779 → 962
    RhoGEF; RhoGEF domain

  16. XM_030252536.1 → XP_030108396.1  rho guanine nucleotide exchange factor 11 isoform X17

    UniProtKB/TrEMBL
    E9Q0A3
    Conserved Domains (5) summary
    cd08753
    Location:295 → 439
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03247
    Location:1076 → 1418
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:57 → 131
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:945 → 1087
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:744 → 927
    RhoGEF; RhoGEF domain

  17. XM_006501269.2 → XP_006501332.1  rho guanine nucleotide exchange factor 11 isoform X7

    UniProtKB/TrEMBL
    E9Q0A3
    Conserved Domains (5) summary
    cd08753
    Location:330 → 474
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03247
    Location:1111 → 1453
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:46 → 120
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:980 → 1122
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:779 → 962
    RhoGEF; RhoGEF domain

  18. XM_036162999.1 → XP_036018892.1  rho guanine nucleotide exchange factor 11 isoform X10

    UniProtKB/TrEMBL
    E9Q0A3
    Conserved Domains (5) summary
    cd08753
    Location:330 → 474
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    smart00325
    Location:769 → 953
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PHA03247
    Location:1101 → 1443
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:46 → 120
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:970 → 1112
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  19. XM_030252535.1 → XP_030108395.1  rho guanine nucleotide exchange factor 11 isoform X9

    UniProtKB/TrEMBL
    E9Q0A3
    Conserved Domains (5) summary
    cd08753
    Location:330 → 474
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03247
    Location:1110 → 1452
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:46 → 120
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:979 → 1121
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:778 → 961
    RhoGEF; RhoGEF domain

  20. XM_030252537.1 → XP_030108397.1  rho guanine nucleotide exchange factor 11 isoform X20

    UniProtKB/TrEMBL
    E9Q0A3
    Conserved Domains (5) summary
    cd08753
    Location:284 → 428
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03247
    Location:1065 → 1407
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:46 → 120
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:934 → 1076
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:733 → 916
    RhoGEF; RhoGEF domain

  21. XM_030252538.1 → XP_030108398.1  rho guanine nucleotide exchange factor 11 isoform X21

    Conserved Domains (3) summary
    PHA03247
    Location:450 → 792
    PHA03247; large tegument protein UL36; Provisional
    cd13391
    Location:319 → 461
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:118 → 301
    RhoGEF; RhoGEF domain

RNA

  1. XR_004941301.1 RNA Sequence

    Related
    ENSMUST00000152006.2
Nucleotide Protein Strain
Heading Accession and Version

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