Tal1 T cell acute lymphocytic leukemia 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tal1provided by MGI
Official Full Name: T cell acute lymphocytic leukemia 1provided by MGI
Primary source: MGI:MGI:98480
See related: Ensembl:ENSMUSG00000028717 AllianceGenome:MGI:98480
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hpt; Scl; tal-1; bHLHa17; SCL/tal-1
Summary: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and transmembrane receptor protein tyrosine kinase activator activity. Contributes to DNA binding activity. Involved in embryonic hemopoiesis; positive regulation of erythrocyte differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including hemopoiesis; neurogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including cardiovascular system; central nervous system; extraembryonic component; hemolymphoid system; and sensory organ. Used to study lymphoid leukemia. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14.5 (RPKM 43.3), liver E14 (RPKM 39.2) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D1; 4 52.73 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (114913623..114928952)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (115056426..115071755)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Isoforms of the TAL1 transcription factor have different roles in hematopoiesis and cell growth.
Title: Isoforms of the TAL1 transcription factor have different roles in hematopoiesis and cell growth.
Identifying a novel role for the master regulator Tal1 in the Endothelial to Hematopoietic Transition.
Title: Identifying a novel role for the master regulator Tal1 in the Endothelial to Hematopoietic Transition.
TAL1 cooperates with PI3K/AKT pathway activation in T-cell acute lymphoblastic leukemia.
Title: TAL1 cooperates with PI3K/AKT pathway activation in T-cell acute lymphoblastic leukemia.
The transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis.
Title: The transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis.
A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis.
Title: A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis.
ADHD-like behaviors caused by inactivation of a transcription factor controlling the balance of inhibitory and excitatory neuron development in the mouse anterior brainstem.
Title: ADHD-like behaviors caused by inactivation of a transcription factor controlling the balance of inhibitory and excitatory neuron development in the mouse anterior brainstem.
The cell-type-specific regions of open chromatin pinpointed two TAL1-bound endothelial enhancers in early mouse organogenesis.
Title: Single-cell chromatin accessibility maps reveal regulatory programs driving early mouse organogenesis.
Scl and Lyl1 share functional roles in platelet production by regulating expression of partner proteins including Gata1. This functional redundancy provides one explanation for the absence of Scl and Lyl1 mutations in inherited thrombocytopenia.
Title: Shared roles for Scl and Lyl1 in murine platelet production and function.
Tal1 limits the expression of multiple E2A target genes in HSCs and controls the balance of myeloid versus T lymphocyte differentiation potential in lymphomyeloid-primed progenitors.
Title: Cutting Edge: Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1.
Ectopic expression of the TAL1 transcription factor and Pten deletion are bona-fide cooperating events.
Title: Defining the molecular basis of oncogenic cooperation between TAL1 expression and Pten deletion in T-ALL using a novel pro-T-cell model system.

Submit: New GeneRIF Correction See all GeneRIFs (78)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1)
Targeted (8) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tal1 (e-PCR), detects polymorphism
- UniSTS:265482

M59764 (e-PCR)
- UniSTS:124960

Tal1 (e-PCR), detects polymorphism
- UniSTS:462700

Tal1 (e-PCR), detects polymorphism
- UniSTS:516505

Tal1 (e-PCR), detects polymorphism
- UniSTS:144541

Tal1 (e-PCR), detects polymorphism
- UniSTS:144542

Tal1 (e-PCR), detects polymorphism
- UniSTS:144543

Tal1 (e-PCR), detects polymorphism
- UniSTS:516556

Tal1 (e-PCR), detects polymorphism
- UniSTS:546042

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables E-box binding	IDA Inferred from Direct Assay more info	PubMed
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within astrocyte fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within central nervous system neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within definitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_negative_effect erythrocyte differentiation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within erythrocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within generation of neurons	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemangioblast cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within megakaryocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within megakaryocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myeloid cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within platelet formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of erythrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mast cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within spinal cord association neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_positive_effect transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: T-cell acute lymphocytic leukemia protein 1 homolog

Names: stem cell protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001287388.2 → NP_001274317.1 T-cell acute lymphocytic leukemia protein 1 homolog

See identical proteins and their annotated locations for NP_001274317.1

Status: VALIDATED

Source sequence(s)

AL670035

Consensus CDS

CCDS18486.1

UniProtKB/Swiss-Prot

P22091

UniProtKB/TrEMBL

Q3TZH7, Q9JK33

Related

ENSMUSP00000125202.2, ENSMUST00000161601.8

Conserved Domains (1) summary

cd19706
Location:185 → 249

bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
NM_001425779.1 → NP_001412708.1 T-cell acute lymphocytic leukemia protein 1 homolog

Status: VALIDATED

Source sequence(s)

AL670035

UniProtKB/Swiss-Prot

P22091

UniProtKB/TrEMBL

Q3TZH7
NM_001425780.1 → NP_001412709.1 T-cell acute lymphocytic leukemia protein 1 homolog

Status: VALIDATED

Source sequence(s)

AL670035

UniProtKB/Swiss-Prot

P22091

UniProtKB/TrEMBL

Q3TZH7
NM_001425781.1 → NP_001412710.1 T-cell acute lymphocytic leukemia protein 1 homolog

Status: VALIDATED

Source sequence(s)

AL670035

UniProtKB/Swiss-Prot

P22091

UniProtKB/TrEMBL

Q3TZH7
NM_001425782.1 → NP_001412711.1 T-cell acute lymphocytic leukemia protein 1 homolog

Status: VALIDATED

Source sequence(s)

AL670035

UniProtKB/Swiss-Prot

P22091

UniProtKB/TrEMBL

Q3TZH7
NM_001425783.1 → NP_001412712.1 T-cell acute lymphocytic leukemia protein 1 homolog

Status: VALIDATED

Source sequence(s)

AL670035

UniProtKB/Swiss-Prot

P22091

UniProtKB/TrEMBL

Q3TZH7
NM_001425784.1 → NP_001412713.1 T-cell acute lymphocytic leukemia protein 1 homolog

Status: VALIDATED

Source sequence(s)

AL670035

UniProtKB/Swiss-Prot

P22091

UniProtKB/TrEMBL

Q3TZH7
NM_001425785.1 → NP_001412714.1 T-cell acute lymphocytic leukemia protein 1 homolog

Status: VALIDATED

Source sequence(s)

AL670035

UniProtKB/Swiss-Prot

P22091

UniProtKB/TrEMBL

Q3TZH7
NM_001425786.1 → NP_001412715.1 T-cell acute lymphocytic leukemia protein 1 homolog

Status: VALIDATED

Source sequence(s)

AL670035

UniProtKB/Swiss-Prot

P22091

UniProtKB/TrEMBL

Q3TZH7
NM_001425787.1 → NP_001412716.1 T-cell acute lymphocytic leukemia protein 1 homolog

Status: VALIDATED

Source sequence(s)

AL670035

UniProtKB/Swiss-Prot

P22091

UniProtKB/TrEMBL

Q3TZH7
NM_001425788.1 → NP_001412717.1 T-cell acute lymphocytic leukemia protein 1 homolog

Status: VALIDATED

Source sequence(s)

AL670035

UniProtKB/Swiss-Prot

P22091

UniProtKB/TrEMBL

Q3TZH7
NM_011527.4 → NP_035657.1 T-cell acute lymphocytic leukemia protein 1 homolog

See identical proteins and their annotated locations for NP_035657.1

Status: VALIDATED

Source sequence(s)

AL670035

Consensus CDS

CCDS18486.1

UniProtKB/Swiss-Prot

P22091

UniProtKB/TrEMBL

Q3TZH7, Q9JK33

Related

ENSMUSP00000030489.3, ENSMUST00000030489.9

Conserved Domains (1) summary

cd19706
Location:185 → 249

bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins