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Tagln2 transgelin 2 [ Mus musculus (house mouse) ]

Gene ID: 21346, updated on 9-May-2024

Summary

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Official Symbol
Tagln2provided by MGI
Official Full Name
transgelin 2provided by MGI
Primary source
MGI:MGI:1312985
See related
Ensembl:ENSMUSG00000026547 AllianceGenome:MGI:1312985
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sm22B; Sm22a; SM22beta; 2700094C18Rik
Summary
Predicted to be involved in epithelial cell differentiation. Predicted to be active in cytoskeleton. Is expressed in several structures, including autopod; cardiovascular system; gut; hemolymphoid system gland; and telencephalon ventricular layer. Orthologous to human TAGLN2 (transgelin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 455.3), lung adult (RPKM 276.3) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H3; 1 79.89 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (172327813..172334942)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172500246..172507375)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4391 Neighboring gene SLAM family member 9 Neighboring gene immunoglobulin superfamily, member 9 Neighboring gene STARR-positive B cell enhancer ABC_E2587 Neighboring gene STARR-positive B cell enhancer ABC_E9066 Neighboring gene STARR-seq mESC enhancer starr_03067 Neighboring gene STARR-positive B cell enhancer ABC_E7779 Neighboring gene cilia and flagella associated protein 45 Neighboring gene STARR-positive B cell enhancer mm9_chr1:174458799-174459099 Neighboring gene RIKEN cDNA 4933439K11 gene Neighboring gene STARR-seq mESC enhancer starr_03068 Neighboring gene V-set and immunoglobulin domain containing 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy. Kim HR, et al. J Hematol Oncol, 2021 Mar 17. PMID 33731208, Free PMC Article
  2. Cytoskeletal transgelin 2 contributes to gender-dependent adipose tissue expandability and immune function. Ortega FJ, et al. FASEB J, 2019 Aug. PMID 31145872
  3. An Essential Role for TAGLN2 in Phagocytosis of Lipopolysaccharide-activated Macrophages. Kim HR, et al. Sci Rep, 2017 Aug 18. PMID 28821818, Free PMC Article
  4. Transgelin-2 in B-Cells Controls T-Cell Activation by Stabilizing T Cell - B Cell Conjugates. Na BR, et al. PLoS One, 2016. PMID 27232882, Free PMC Article
  5. Identification and verification of transgelin-2 as a potential biomarker of tumor-derived lung-cancer endothelial cells by comparative proteomics. Jin H, et al. J Proteomics, 2016 Mar 16. PMID 26721444

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA133b alleviates doxorubicininduced cardiomyocyte apoptosis and cardiac fibrosis by targeting PTBP1 and TAGLN2.
    Title: MicroRNA‑133b alleviates doxorubicin‑induced cardiomyocyte apoptosis and cardiac fibrosis by targeting PTBP1 and TAGLN2.
  2. Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy.
    Title: Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy.
  3. Current findings highlight the contribution of cytoskeletal TAGLN2 to the obese phenotype in a gender-dependent manner
    Title: Cytoskeletal transgelin 2 contributes to gender-dependent adipose tissue expandability and immune function.
  4. An unidentified role of TAGLN2 in regulation of trophoblast invasion.
    Title: Transgelin 2 is required for embryo implantation by promoting actin polymerization.
  5. dual functional nature of TAGLN2-G-actin polymerization and Arp2/3 complex inhibition-may account for the mechanisms of filopodia development at the edge of Arp2/3-rich lamellipodia in various cell types
    Title: TAGLN2 polymerizes G-actin in a low ionic state but blocks Arp2/3-nucleated actin branching in physiological conditions.
  6. These results revealed a novel function of TAGLN2 as a molecular armament required for host defense.
    Title: An Essential Role for TAGLN2 in Phagocytosis of Lipopolysaccharide-activated Macrophages.
  7. transgelin-2 may also be involved in IS stability in B-cells, thereby influencing T-cell function
    Title: Transgelin-2 in B-Cells Controls T-Cell Activation by Stabilizing T Cell - B Cell Conjugates.
  8. All these results indicated a crucial role for Tagln2 in TECs for tumor development and metastasis.
    Title: Identification and verification of transgelin-2 as a potential biomarker of tumor-derived lung-cancer endothelial cells by comparative proteomics.
  9. A novel function of TAGLN2 in enhancing T cell responses by controlling actin stability at the immunological synapse.
    Title: TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse.
  10. The results indicate that miR-133b may play important roles in the growth and maturation of oocytes by regulating its potential target, TAGLN2, at both transcription and translation levels.
    Title: MiR-133b regulates the expression of the Actin protein TAGLN2 during oocyte growth and maturation: a potential target for infertility therapy.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (5) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0120

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transgelin-2
Names
SM22-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178598.2 → NP_848713.1  transgelin-2

    See identical proteins and their annotated locations for NP_848713.1

    Status: VALIDATED

    Source sequence(s)
    AK151576
    Consensus CDS
    CCDS35784.1
    UniProtKB/Swiss-Prot
    Q3TIB8, Q6A0C6, Q78ZX2, Q91VU2, Q9WVA4
    Related
    ENSMUSP00000106861.2, ENSMUST00000111230.8
    Conserved Domains (3) summary
    COG5199
    Location:14 → 188
    SCP1; Calponin [Cytoskeleton]
    cd00014
    Location:25 → 136
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00402
    Location:174 → 197
    Calponin; Calponin family repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    172327813..172334942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVA4.4 GenPept UniProtKB/Swiss-Prot:Q9WVA4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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