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Dstyk dual serine/threonine and tyrosine protein kinase [ Mus musculus (house mouse) ]

Gene ID: 213452, updated on 5-Mar-2024

Summary

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Official Symbol
Dstykprovided by MGI
Official Full Name
dual serine/threonine and tyrosine protein kinaseprovided by MGI
Primary source
MGI:MGI:1925064
See related
Ensembl:ENSMUSG00000042046 AllianceGenome:MGI:1925064
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ripk5; C820013G01; A930019K20Rik; C430014H23Rik
Summary
Predicted to enable ATP binding activity and protein kinase activity. Predicted to be involved in several processes, including cellular response to fibroblast growth factor stimulus; positive regulation of kinase activity; and positive regulation of signal transduction. Predicted to act upstream of or within phosphorylation. Located in apical plasma membrane; basolateral plasma membrane; and cytoplasm. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and skin. Human ortholog(s) of this gene implicated in CAKUT1 and hereditary spastic paraplegia 23. Orthologous to human DSTYK (dual serine/threonine and tyrosine protein kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 5.7), ovary adult (RPKM 5.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dstyk in Genome Data Viewer
Location:
1 E4; 1 57.24 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (132345127..132394697)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132417389..132466959)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domains 2 Neighboring gene predicted gene, 57562 Neighboring gene RIKEN cDNA 6030442K20 gene Neighboring gene STARR-seq mESC enhancer starr_02257 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:134373585-134373776 Neighboring gene retinoblastoma binding protein 5, histone lysine methyltransferase complex subunit Neighboring gene transmembrane protein 81 Neighboring gene contactin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DSTYK kinase domain ablation impaired the mice capabilities of learning and memory in water maze test. Li K, et al. Int J Clin Exp Pathol, 2014. PMID 25400726, Free PMC Article
  2. RIP5 is a RIP-homologous inducer of cell death. Zha J, et al. Biochem Biophys Res Commun, 2004 Jun 25. PMID 15178406
  3. Mutations in DSTYK and dominant urinary tract malformations. Sanna-Cherchi S, et al. N Engl J Med, 2013 Aug 15. PMID 23862974, Free PMC Article
  4. Immunohistochemical Expression Pattern of FGFR1, FGFR2, RIP5, and HIP2 in Developing and Postnatal Kidneys of Dab1(-/-) (yotari) Mice. Kelam N, et al. Int J Mol Sci, 2022 Feb 11. PMID 35216141, Free PMC Article
  5. Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain. Peng J, et al. Biochim Biophys Acta, 2006 Nov-Dec. PMID 17123648, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DSTYK homozygous knockout mice show impaired capabilities of learning and memory.
    Title: DSTYK kinase domain ablation impaired the mice capabilities of learning and memory in water maze test.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to fibroblast growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dual serine/threonine and tyrosine protein kinase
Names
dusty PK
dusty protein kinase
receptor interacting protein kinase 5
receptor-interacting serine/threonine-protein kinase 5
NP_766104.2
XP_036019313.1
XP_036019314.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172516.4 → NP_766104.2  dual serine/threonine and tyrosine protein kinase

    See identical proteins and their annotated locations for NP_766104.2

    Status: VALIDATED

    Source sequence(s)
    AK050542, AK082434, AK082904, AK083696, AK132119, BB749395, CJ110290
    Consensus CDS
    CCDS15285.1
    UniProtKB/Swiss-Prot
    Q3ULK4, Q5EBN5, Q6XUX1, Q8C7D4, Q8C923, Q9CTP7
    UniProtKB/TrEMBL
    A0A087WP69
    Related
    ENSMUSP00000035358.8, ENSMUST00000045110.14
    Conserved Domains (2) summary
    smart00220
    Location:651 → 895
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13975
    Location:649 → 910
    PKc_Dusty; Catalytic domain of the Dual-specificity Protein Kinase, Dusty

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    132345127..132394697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163420.1 → XP_036019313.1  dual serine/threonine and tyrosine protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A087WP69
    Conserved Domains (1) summary
    cd13975
    Location:551 → 812
    PKc_Dusty; Catalytic domain of the Dual-specificity Protein Kinase, Dusty

  2. XM_036163421.1 → XP_036019314.1  dual serine/threonine and tyrosine protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A087WP69
    Conserved Domains (1) summary
    cd13975
    Location:551 → 812
    PKc_Dusty; Catalytic domain of the Dual-specificity Protein Kinase, Dusty

RNA

  1. XR_387156.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6XUX1.1 GenPept UniProtKB/Swiss-Prot:Q6XUX1

Gene LinkOut

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