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P2ry10b purinergic receptor P2Y, G-protein coupled 10B [ Mus musculus (house mouse) ]

Gene ID: 213438, updated on 11-Apr-2024

Summary

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Official Symbol
P2ry10bprovided by MGI
Official Full Name
purinergic receptor P2Y, G-protein coupled 10Bprovided by MGI
Primary source
MGI:MGI:2441814
See related
Ensembl:ENSMUSG00000054293 AllianceGenome:MGI:2441814
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P2ry10; A630033H20Rik
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 2.9), spleen adult (RPKM 2.2) and 15 other tissues See more
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Genomic context

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Location:
X D; X 47.45 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (106192533..106217268)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (107148927..107173661)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene lysophosphatidic acid receptor 4 Neighboring gene STARR-seq mESC enhancer starr_47740 Neighboring gene purinergic receptor P2Y, G-protein coupled 10 Neighboring gene STARR-positive B cell enhancer ABC_E11054 Neighboring gene STARR-positive B cell enhancer ABC_E11686 Neighboring gene prohibitin pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chrX:104413022-104413322 Neighboring gene STARR-positive B cell enhancer ABC_E7704 Neighboring gene G protein-coupled receptor 174 Neighboring gene alpha-enolase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TGFα shedding assay: an accurate and versatile method for detecting GPCR activation. Inoue A, et al. Nat Methods, 2012 Oct. PMID 22983457
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
purinergic receptor P2Y G-protein coupled 10-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122595.1 → NP_001116067.1  purinergic receptor P2Y G-protein coupled 10-like

    See identical proteins and their annotated locations for NP_001116067.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL928594
    Consensus CDS
    CCDS41099.1
    UniProtKB/TrEMBL
    Q8BY68
    Related
    ENSMUSP00000136348.2, ENSMUST00000180182.2
    Conserved Domains (2) summary
    cd14964
    Location:23 → 50
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 304
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_001122596.1 → NP_001116068.1  purinergic receptor P2Y G-protein coupled 10-like

    See identical proteins and their annotated locations for NP_001116068.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL928594
    Consensus CDS
    CCDS41099.1
    UniProtKB/TrEMBL
    Q8BY68
    Related
    ENSMUSP00000133122.2, ENSMUST00000167673.2
    Conserved Domains (2) summary
    cd14964
    Location:23 → 50
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 304
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. NM_175442.4 → NP_780651.1  purinergic receptor P2Y G-protein coupled 10-like

    See identical proteins and their annotated locations for NP_780651.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL928594
    Consensus CDS
    CCDS41099.1
    UniProtKB/TrEMBL
    Q8BY68
    Related
    ENSMUSP00000065588.3, ENSMUST00000067249.3
    Conserved Domains (2) summary
    cd14964
    Location:23 → 50
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 304
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    106192533..106217268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161902.1 → XP_036017795.1  purinergic receptor P2Y G-protein coupled 10-like isoform X1

    UniProtKB/TrEMBL
    Q8BY68
    Conserved Domains (2) summary
    cd14964
    Location:23 → 50
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 304
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version

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